發(fā)布時(shí)間：2018-06-10 09:00

  本文選題：肝纖維化 + 肝細(xì)胞��； 參考：《中國(guó)中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志》2017年09期

【摘要】：肝纖維化的主要病機(jī)是腎虛應(yīng)從腎論治。中醫(yī)認(rèn)為"虛極及腎",從病程、肝細(xì)胞再生能力、肝細(xì)胞端粒長(zhǎng)度、卵圓細(xì)胞、肝細(xì)胞EMT現(xiàn)象、甲胎蛋白、白蛋白、肥大細(xì)胞、TGF-β通路、Wnt/β-catenin通路等方面看,肝纖維化時(shí)肝細(xì)胞的再生能力轉(zhuǎn)而弱于間質(zhì)的增殖修復(fù)能力,說(shuō)明肝細(xì)胞生機(jī)不足;肝組織開(kāi)始出現(xiàn)胚胎化特征,說(shuō)明已"損及胎元",所以肝纖維化應(yīng)從腎論治。目前對(duì)肝纖維化的辨證主要有肝郁脾虛、肝腎陰虛、脾腎陽(yáng)虛、瘀血阻絡(luò)、濕熱中阻和氣滯血瘀,從腎論治為主者極少。在肝纖維化病理中,如果主要著眼于"纖維"就會(huì)更注重"實(shí)證";如果主要著眼于"肝細(xì)胞"就會(huì)更注重"虛證"。盡管肝細(xì)胞占肝臟細(xì)胞總數(shù)超過(guò)80%,但在肝纖維化過(guò)程中的病理生理作用一直被忽略。即使目前重視程度提高,但主要也集中在其產(chǎn)生纖維方面的作用,而相對(duì)忽視其衰老和增殖修復(fù)能力下降。
[Abstract]:The main pathogenesis of liver fibrosis is kidney deficiency should be treated from the kidney. TCM believes that "deficiency pole and kidney" can be seen from the aspects of course of disease, ability of liver cell regeneration, length of telomere, oval cell, EMT phenomenon of liver cell, alpha-fetoprotein, albumin, mast cell TGF- 尾 pathway and Wnt- 尾 -catenin pathway. The regeneration ability of liver cells is weaker than that of mesenchymal proliferation and repair, which indicates that the liver cells lack of vitality, and that the liver tissue begins to have the characteristics of embryogenesis, which indicates that it has "damaged the fetal elements", so the liver fibrosis should be treated from the kidney. At present, there are mainly liver stagnation and spleen deficiency, liver and kidney yin deficiency, spleen and kidney yang deficiency, blood stasis blocking collaterals, damp-heat middle obstruction and qi stagnation and blood stasis. In liver fibrosis pathology, if focus on "fiber" will pay more attention to "empirical", if focus on "liver cells" will pay more attention to "deficiency syndrome". Although liver cells account for more than 80% of liver cells, the pathophysiological role of liver fibrosis has been neglected. Although the current attention is increased, it mainly focuses on its fiber production, while ignoring the decline of its aging and proliferative repair ability.
【作者單位】： 中國(guó)中醫(yī)科學(xué)院中醫(yī)基礎(chǔ)理論研究所;
【基金】：中央級(jí)公益性科研院所基本科研業(yè)務(wù)費(fèi)專項(xiàng)資金自主選題項(xiàng)目(YZ-1660)-補(bǔ)腎法對(duì)肝纖維化大鼠的干預(yù)作用及對(duì)TGF-β/Smad信號(hào)通路的影響
【分類號(hào)】：R259

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本文編號(hào)：2002667