本文選題：宮頸柱狀上皮異位 + 物理治療　； 參考：《時珍國醫(yī)國藥》2017年07期

【摘要】：目的觀察我院國家級名老中醫(yī)易修珍經(jīng)驗方——固氣利濕湯對宮頸柱狀上皮異位患者經(jīng)物理治療后創(chuàng)面修復(fù)的臨床療效,并且從AQP2角度探討中藥起效的作用機制。方法 62例中重度宮頸柱狀上皮異位患者,隨機分為對照組(n=30)和治療組(n=32)。均給予物理治療的方法,對照組術(shù)后給予奧硝唑500mg bid口服1周預(yù)防感染,治療組除外奧硝唑預(yù)防感染之外,同時給予中藥固氣利濕湯口服日一劑,持續(xù)2周。術(shù)后每2周隨訪一次,記錄患者陰道排液持續(xù)時間、陰道排液量、陰道出血時間、創(chuàng)面愈合時間,同時觀察術(shù)后的不良反應(yīng)。兩組治療前均于陰道鏡下取宮頸異位柱狀上皮部位的組織活檢,術(shù)后2周宮頸鱗柱交界處取材少量,測定AQP2蛋白表達量,探討中藥發(fā)揮作用的機制。結(jié)果兩組患者基本資料比較,未見統(tǒng)計學(xué)差異(P0.05)。治療組的陰道排液持續(xù)時間、陰道排液量、創(chuàng)面愈合時間,均顯著低于對照組(P0.05),陰道出血時間未見差異(P0.05)�？偟闹委熜Ч�,治療組優(yōu)于對照組(P0.05)。治療后AQP2蛋白表達量,治療組顯著低于對照組(P0.05)。結(jié)論宮頸柱狀上皮異位患者給予物理治療是一種安全有效的治療方法,術(shù)后給予中藥固氣利濕湯治療,可顯著降低患者術(shù)后陰道排液量、陰道排液時間,促進創(chuàng)面的愈合,提高治療效果。減少陰道排液的作用機制可能與下調(diào)AQP2蛋白有關(guān)系。
[Abstract]:Objective to observe the clinical curative effect of Yi Xiuzhen experience decoction (GQLSD), a national famous traditional Chinese medicine, on wound repair of patients with cervical columnar epithelial ectopic after physical therapy, and to explore the mechanism of the effect of traditional Chinese medicine from AQP2 point of view. Methods Sixty-two patients with moderate and severe ectopic cervical columnar epithelium were randomly divided into control group (n = 30) and treatment group (n = 32). The control group was given ornidazole 500mg bid for 1 week to prevent infection, the treatment group except ornidazole for preventing infection, and the treatment group for 2 weeks. The patients were followed up every 2 weeks to record the duration of vaginal effusion, the amount of vaginal effusion, the time of vaginal bleeding, the time of wound healing, and the adverse reactions after operation. Tissue biopsy of cervical ectopic columnar epithelium was performed under colposcopy in both groups before treatment. A small amount of samples were obtained at the junction of cervical squamous column 2 weeks after operation to determine the expression of AQP2 protein and to explore the mechanism of Chinese medicine acting on it. Results there was no statistical difference between the two groups (P 0.05). The duration of vaginal effusion, the amount of vaginal effusion and the healing time of wound in the treatment group were significantly lower than those in the control group (P 0.05). There was no difference in vaginal bleeding time between the two groups (P 0.05). The total therapeutic effect of the treatment group was better than that of the control group (P 0.05). After treatment, the expression of AQP2 protein in the treatment group was significantly lower than that in the control group (P 0.05). Conclusion physical therapy is a safe and effective method for patients with cervical columnar epithelium ectopic. After operation, the treatment with Gushi Lishi decoction can significantly reduce the amount of vaginal efflux, the time of vaginal drainage, and promote the wound healing. Improve the therapeutic effect. The mechanism of reducing vaginal effusion may be related to the down-regulation of AQP2 protein.
【作者單位】： 云南省中醫(yī)醫(yī)院;云南中醫(yī)學(xué)院;
【基金】：云南省衛(wèi)生科技計劃項目(No.2014NS303)
【分類號】：R271.9

【參考文獻】

相關(guān)期刊論文 前5條

1 孫曉天;阮海燕;仇曉潤;董欣欣;丁士e，

本文編號：1997011