本文選題：抑郁癥 + 化痰解郁方　； 參考：《成都中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：通過臨床觀察,驗(yàn)證化痰解郁方治療輕中度抑郁癥發(fā)作期(痰熱上擾證)的臨床療效及安全性。方法：采用CCMD-3版抑郁發(fā)作的診斷標(biāo)準(zhǔn)確定抑郁的存在,并采用中醫(yī)證候標(biāo)準(zhǔn)進(jìn)行辨證分型,病例選自2015年09月至2016年2月成都中醫(yī)藥大學(xué)附屬醫(yī)院神經(jīng)內(nèi)科門診的符合要求的患者63例,用數(shù)字隨機(jī)表隨機(jī)、對(duì)照試驗(yàn)的方法,分為試驗(yàn)組(中藥組)、對(duì)照組(西藥組),兩組比例為2：1,即試驗(yàn)組42例、對(duì)照組21例,實(shí)驗(yàn)中脫落4例,治療方法：試驗(yàn)組給予化痰解郁方口服,每天三次,每次200ml；對(duì)照組給予百優(yōu)解口服,每天一次,每次20mg,療程8周,分別在用藥前、用藥2周、4周、6周、8周后對(duì)各組進(jìn)行評(píng)估,包括中醫(yī)癥狀的觀察和HAMD等量表評(píng)分情況。在用藥前及用藥8周后進(jìn)行安全性指標(biāo)的觀測(cè)以評(píng)定藥物安全性。結(jié)果：①療效評(píng)價(jià)：對(duì)于輕中度抑郁癥(痰熱上擾證)患者,試驗(yàn)組：有效32例,無效7例,總有效率為82.1%；治療組：有效17例,無效3例,總有效率為85%。試驗(yàn)組治療后與治療前比較有很好的療效(P=0.000),對(duì)照組治療后與治療前比較有很好的療效(P=0.000),但兩組療效之間無明顯差異(P=0.775)。②抑郁相關(guān)因子的改善評(píng)價(jià),兩組相比,試驗(yàn)組在改善胃腸道癥狀、睡眠障礙癥狀方面均有明顯的優(yōu)勢(shì)(P0.05)。③中醫(yī)證候的改善評(píng)價(jià),試驗(yàn)組：有效35例,無效4例,總有效率為89.7%；治療組：有效11例,無效9例,總有效率為55%。兩組療效之間有明顯差異(P=0.020),試驗(yàn)組在中醫(yī)癥候的改善上優(yōu)于對(duì)照組。④安全性觀察：試驗(yàn)組和對(duì)照組不良反應(yīng)發(fā)生率之間有差異(P=0.041),試驗(yàn)組不良反應(yīng)發(fā)生率低于對(duì)照組。結(jié)論：化痰解郁方對(duì)輕中度抑郁癥(痰熱上擾證)患者有明顯的療效,而且無明顯的不良反應(yīng)。
[Abstract]:Objective: to verify the clinical efficacy and safety of Huatan Jieyu prescription (Huatan Jieyu decoction) in the treatment of mild and moderate depression. Methods: the existence of depression was determined by the diagnostic criteria of CCMD-3 version of depression, and the syndrome differentiation criteria of traditional Chinese medicine (TCM) were used. From September 2015 to February 2016, 63 patients in the Department of Neurology, affiliated Hospital of Chengdu University of traditional Chinese Medicine, were selected. The experimental group was divided into two groups: the traditional Chinese medicine group and the control group. The ratio of the two groups was 2: 1, that is, 42 cases in the experimental group and 21 cases in the control group. The treatment methods were as follows: the experimental group was given Huatan Jieyu decoction three times a day. The control group was given Baiyou Jie orally, once a day, 20 mg every time, for 8 weeks. Before and after 2 weeks and 4 weeks and 6 weeks and 8 weeks, the control group was evaluated, including the observation of TCM symptoms and Hamd score. Safety indexes were observed before and 8 weeks after administration to evaluate drug safety. Results: for patients with mild and moderate depression (phlegm heat disturbance), 32 cases were effective, 7 cases were ineffective, and the total effective rate was 82.1, in the treatment group, 17 cases were effective, 3 cases were ineffective, and the total effective rate was 85.1%. There was a good effect after treatment in the trial group and 0.000 in the control group. However, there was no significant difference between the two groups in the improvement of depression related factors, and there was no significant difference between the two groups in the improvement of the depression related factors, and there was no significant difference between the two groups. In the trial group, there were obvious advantages in improving gastrointestinal symptoms and sleeping disorder symptoms. In the trial group, 35 cases were effective, 4 cases were ineffective, the total effective rate was 89.7; in the treatment group, 11 cases were effective and 9 cases were ineffective. The total effective rate is 55. There was significant difference between the two groups in curative effect. The improvement of TCM symptoms in the trial group was better than that in the control group. The safety observation showed that there was a difference in the incidence of adverse reactions between the experimental group and the control group, and the incidence of adverse reactions in the experimental group was lower than that in the control group. Conclusion: Huatan Jieyu prescription has obvious curative effect on mild and moderate depression (phlegm heat disturbance syndrome), and has no obvious adverse reaction.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R277.7

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本文編號(hào)：1995975