本文選題：溫陽解毒消癭方 + 脾腎陽虛��； 參考：《山東中醫(yī)藥大學》2016年碩士論文

【摘要】：目的:本研究旨在通過觀察以健脾疏肝、溫陽解毒、消癭散結為組方原則的溫陽解毒消癭方治療脾腎陽虛型橋本甲狀腺炎的臨床療效,客觀評價其療效及安全性,探討其作用機制和治療優(yōu)勢。方法:采用隨機對照研究,選取脾腎陽虛型橋本甲狀腺炎患者60例,隨機分為治療組、對照組各30例。治療前兩組均給予優(yōu)甲樂,早餐前口服,劑量根據患者自身甲狀腺激素情況調整,控制甲狀腺激素在正常范圍為止。治療組在此基礎上加用溫陽解毒消癭方,療程均為12周,觀察治療前后兩組患者臨床癥狀、體征,血清甲狀腺激素水平、血清甲狀腺自身抗體滴度以及女性患者血清雌二醇水平的改變,對相關數(shù)據采用統(tǒng)計軟件進行統(tǒng)計分析,評價其綜合療效。結果:對照組總有效率為89.5%,治療組總有效率為58.3%。在改善橋本病各項癥狀、體征方面前后比較,治療組明顯優(yōu)于對照組;在降低甲狀腺抗體滴度方面前后比較,治療組明顯優(yōu)于對照組;在改善女性患者血清雌二醇水平水平方面前后比較,治療組明顯優(yōu)于對照組。經統(tǒng)計學統(tǒng)計,試驗組未發(fā)現(xiàn)明顯不良反應,安全性較高。結論:以健脾疏肝、溫陽解毒、消癭散結為組方原則的溫陽解毒消癭方可以明顯改善脾腎陽虛型橋本甲狀腺炎患者的臨床癥狀、體征,改善甲狀腺激素水平、甲狀腺自身抗體水平與女性雌二醇水平,且無明顯不良反應,是一種有效、安全的治療方法,值得進一步開發(fā)利用。
[Abstract]:Objective: the purpose of this study was to observe the clinical effect of Wenyang jiedu Xiaoying recipe (WJXD) on treating Hashimoto thyroiditis with spleen and kidney yang deficiency by observing the principle of invigorating spleen and soothing liver, warming yang and detoxifying toxin, and eliminating gall dispersal, and to evaluate objectively its efficacy and safety. To explore its mechanism and therapeutic advantages. Methods: 60 cases of Hashimoto's thyroiditis with deficiency of spleen and kidney yang were randomly divided into treatment group (n = 30) and control group (n = 30). Before treatment, both groups were given metochlor, oral before breakfast, the dosage was adjusted according to the patients' own thyroid hormone, and the thyroid hormone was controlled in the normal range. The treatment group was treated with Wenyang jiedu Xiaoying recipe for 12 weeks. The clinical symptoms, signs and serum thyroid hormone levels were observed before and after treatment. The changes of serum thyroid autoantibody titer and serum estradiol level in female patients were evaluated by statistical software. Results: the total effective rate was 89. 5% in the control group and 58. 3% in the treatment group. In improving the symptoms and signs of Hashimoto's disease, the treatment group was obviously better than the control group, and the treatment group was obviously better than the control group in reducing thyroid antibody titer. The treatment group was better than the control group in improving the serum estradiol level of female patients. According to statistics, no obvious adverse reactions were found in the test group, and the safety was high. Conclusion: Wenyang jiedu Xiaoying prescription based on the principle of invigorating spleen and soothing liver, warming yang and detoxifying toxin, and eliminating gall dispersal can obviously improve the clinical symptoms and signs of Hashimoto's thyroiditis with deficiency of spleen and kidney yang, improve the level of thyroid hormone, and improve the level of thyroid hormone. Thyroid autoantibody level and female estradiol level, and no obvious adverse reactions, is an effective and safe treatment method, worthy of further development and utilization.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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