本文選題：非小細(xì)胞肺癌 + 中藥�。� 參考：《遼寧中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察分析中藥維持治療前后中性粒細(xì)胞與淋巴細(xì)胞比率(NLR)水平變化對(duì)晚期非小細(xì)胞肺癌(NSCLC)患者的生存及療效的影響。材料與方法:所選患者病例均為2010年1月—2015年10月期間于遼寧中醫(yī)藥大學(xué)附屬第二醫(yī)院腫瘤科接受中藥維持治療4周的64例晚期NSCLC患者的住院病例,所有患者予以口服中藥湯劑扶正抗癌治療,且在治療前后均接受過(guò)血常規(guī)檢查,收集患者的臨床資料,包括性別、年齡、吸煙史、病理類型、卡式評(píng)分、維持治療前后的中性粒細(xì)胞計(jì)數(shù)與淋巴細(xì)胞計(jì)數(shù)等。應(yīng)用SPSS 20.0軟件對(duì)維持治療前后NLR變化與晚期NSCLC患者的維持治療療效及生存的關(guān)系。檢驗(yàn)水準(zhǔn)定為P0.05。結(jié)果:1.據(jù)受試者工作特征曲線(ROC),維持治療前NLR截?cái)嘀禐?.06,低于及高于該值的患者中位生存期分別為14、30月(P=0.000),維持治療前NLR水平與性別相關(guān)(P=0.000),維持治療前NLR按3.06為界分組與瘤體療效無(wú)相關(guān)性(P=0.110),與中醫(yī)癥候療效有相關(guān)性(P=0.021)。經(jīng)中藥治療后中醫(yī)主要癥候療效前后差異有統(tǒng)計(jì)學(xué)意義,P0.05。2.維持治療后NLR較維持治療前NLR在部分緩解(PR)組、穩(wěn)定(SD)組均有所下降,在進(jìn)展(PD)組有所上升,但是在PR組(P=0.326)、SD組(P=0.051)和PD組(P=0.099)維持治療前后差異無(wú)統(tǒng)計(jì)學(xué)意義。中醫(yī)癥候療效在維持治療后NLR較維持治療前NLR在各組均有所下降,在有效組維持治療前后差異有顯著性意義(P=0.014)。3.多因素結(jié)果顯示NLR≥3.06(HR=0.249,P0.05)是預(yù)后不良因素。結(jié)論:中藥維持治療前NLR升高是晚期NSCLC患者的預(yù)后不良因素,雖然維持治療前NLR對(duì)瘤體療效無(wú)預(yù)測(cè)作用,但其NLR對(duì)中醫(yī)癥候療效密切相關(guān),并且維持治療前后NLR變化也與療效密切相關(guān)。
[Abstract]:Objective: to observe the influence of the ratio of neutrophil to lymphocyte (NLRR) on the survival and curative effect of NSCLC patients with advanced NSCLC before and after the treatment of traditional Chinese medicine (TCM). Materials and methods: the selected patients were 64 patients with advanced NSCLC who received traditional Chinese medicine (TCM) maintenance therapy for 4 weeks from January 2010 to October 2015 in the Oncology Department of the second affiliated Hospital of Liaoning University of traditional Chinese Medicine. All patients were treated with oral Chinese medicine decoction Fuzheng anticancer therapy, and were examined by blood routine before and after treatment. The clinical data, including sex, age, smoking history, pathological type, card-type score, were collected. Neutrophil count and lymphocyte count were maintained before and after treatment. The relationship between the changes of NLR before and after maintenance therapy with SPSS 20.0 software and the curative effect and survival of patients with advanced NSCLC. The inspection level is set at P0.05. The result is 1: 1. According to the operating characteristic curve of subjects, the truncation value of NLR before maintenance treatment was 3.06, the median survival time of patients below and above this value was 14,30 months, respectively, the NLR level before maintenance was 0.000g / g, and the NLR before maintenance therapy was divided into three groups according to 3.06. There was no correlation between the curative effect of tumor and the curative effect of traditional Chinese medicine (TCM), and there was a correlation between P0. 01 and P0. 021. After the treatment of traditional Chinese medicine, the difference between the main symptoms of traditional Chinese medicine before and after treatment was statistically significant (P 0.05.2). After maintenance, NLR decreased in partial remission group and stable NLR group, and increased in progressive group, but there was no significant difference between PR group and PD group (P 0.051) and PD group (P 0.099) before and after maintenance treatment. The curative effect of TCM syndrome on NLR after maintenance treatment was lower than that before maintenance treatment in all groups, and there was significant difference before and after maintenance treatment in effective group. The multivariate results showed that NLR 鈮，

本文編號(hào)：1975507