本文選題：腸炎愈湯 + 濕熱蘊結(jié)證��； 參考：《湖南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:探討腸炎愈湯直腸灌注治療濕熱蘊結(jié)證潰瘍性直腸炎的臨床療效及安全性。方法:隨機從2015年5月~2015年11月選取符合濕熱蘊結(jié)證潰瘍性直腸炎診斷標準的60例門診患者為研究對象,按隨機數(shù)字法分為對照組和治療組。其中對照組予中藥清腸活血湯直腸灌注治療,治療組予中藥腸炎愈湯直腸灌注治療,觀察兩組治療后臨床療效及安全性。結(jié)果:(1)一般資料結(jié)果:兩組一般資料(性別、年齡、病程、治療史、治療前病情輕重程度)差異比較無統(tǒng)計學(xué)意義(P0.05),具有可比性。(2)實驗結(jié)果:對照組治療后主要癥狀腹瀉、黏液便、肛門墜脹積分分別為(1.40±0.81)分、(1.53±0.68)分、(1.46±0.73)分,治療組主要癥狀腹瀉、黏液便、肛門墜脹積分分別為(0.80±0.76)分、(0.86±0.73)分、(0.83±0.74)分,治療組主要癥狀積分均改善均高于對照組(P0.05),有統(tǒng)計學(xué)意義。兩組經(jīng)不同治療后腸鏡黏膜病變積分改變無統(tǒng)計學(xué)意義(P0.05)。對照組治療后中醫(yī)證候積分平均(6.00±1.43)分,治療組(3.80±1.18)分,兩組中醫(yī)證候積分差異比較有統(tǒng)計學(xué)意義(P0.05)。對照組總有效率73.3%,治療組93.4%,兩組差異比較有統(tǒng)計學(xué)意義(P0.05)。兩組在治療過程中均未出現(xiàn)嚴重不良反應(yīng),安全性高。結(jié)論:腸炎愈湯直腸灌注治療濕熱蘊結(jié)證潰瘍性直腸炎療效確切,安全性高,能有效改善患者腹瀉、黏液便、肛門墜脹主要臨床癥狀。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Changchangyu decoction (YYT) in the treatment of ulcerative proctitis with damp-heat accumulation syndrome. Methods: from May 2015 to November 2015, 60 outpatients with ulcerative colitis of damp-heat accumulation syndrome were randomly selected and divided into control group and treatment group. The control group was treated with rectal perfusion of Qingchang Huoxue decoction and the treatment group was treated with the traditional Chinese medicine Changyu decoction. The clinical efficacy and safety of the two groups were observed. Results: there was no significant difference in general data (sex, age, course of disease, history of treatment, severity of illness before treatment) between the two groups (P 0.05). The scores of mucus stool and anal drop distension were 1.40 鹵0.81) and 1.53 鹵0.68 respectively. The main symptoms of diarrhea, mucus and anal bloating were 0.80 鹵0.76, 0.86 鹵0.74) in the treatment group, respectively. The main symptom scores in the treatment group were all higher than those in the control group (P 0.05), with statistical significance. After different treatment, there was no significant change of mucosal lesion score in the two groups (P 0.05). The average score of TCM syndromes in the control group was 6.00 鹵1.43, and that in the treatment group was 3.80 鹵1.18. The difference of TCM syndromes between the two groups was statistically significant (P 0.05). The total effective rate was 73.3% in the control group and 93.4% in the treatment group. The difference between the two groups was statistically significant (P 0.05). There was no serious adverse reaction in both groups and the safety was high. Conclusion: the rectal perfusion of Changyan Yu decoction is effective and safe in treating ulcerative proctitis with dampness and heat accumulation syndrome. It can effectively improve the main clinical symptoms of diarrhea, mucus stool and anal dropsy.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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