本文選題：桂枝寤湯 + 桂枝寐湯��； 參考：《福建中醫(yī)藥大學(xué)》2016年博士論文

【摘要】：目的：通過對桂枝寤湯和桂枝寐湯治療不寐的臨床研究,歸納總結(jié)桂枝寤湯和桂枝寐湯治療不寐療效差異相關(guān)影響因素,不斷改進(jìn)桂枝寤湯和桂枝寐湯組成及應(yīng)用,有針對性地提高其治療不寐的有效率。方法：選取從2015年3月至2016年3月在馬來西亞霹靂州怡保市仁愛醫(yī)院與星聯(lián)養(yǎng)生堂門診就診并且符合中華中醫(yī)藥學(xué)會發(fā)布的2008年版《中醫(yī)內(nèi)科常見病診療指南·中醫(yī)病證部分》不寐診斷依據(jù)、2001年版《中國精神障礙分類與診斷標(biāo)準(zhǔn)第三版》制定的失眠診斷標(biāo)準(zhǔn)的100例失眠癥患者,參照2002年《中藥新藥臨床研究指導(dǎo)原則(試行)》中“中藥新藥治療失眠的臨床研究指導(dǎo)原則”及WHO最新頒布的失眠臨床療效判斷標(biāo)準(zhǔn)評定,將符合診斷標(biāo)準(zhǔn)及納入、排除標(biāo)準(zhǔn)且病歷資料登記完整并服用桂枝寤湯、桂枝寐湯者分為總有效組和無效組,進(jìn)行有效率統(tǒng)計,并從一般資料和癥狀(包括主要癥狀和次要癥狀)兩大方面進(jìn)行單因素統(tǒng)計,將有意義的單因素再進(jìn)行多因素logistic回歸分析,最后篩選出具有統(tǒng)計學(xué)意義的影響因素。結(jié)果：1、一般資料統(tǒng)計分析：本次研究根據(jù)納入和排除標(biāo)準(zhǔn),經(jīng)收集整理,刪除資料丟失或者登記不完整及失訪病例,共納入100例完整病例,其中總有效組88例,占88%,無效組12例,占12%；一般資料單因素分析,結(jié)果提示：總有效組和無效組在年齡、教育程度、PSQI分?jǐn)?shù)三個項(xiàng)目上有統(tǒng)計學(xué)意義(P0.05)。2、主要癥狀及次要癥狀統(tǒng)計分析：四大主要癥狀單因素統(tǒng)計分析,結(jié)果提示：入睡時間以一小時為界限具有統(tǒng)計學(xué)意義(P0.05)。次要癥狀單因素分析,結(jié)果提示：晨起思睡、注意力不集中、精神不振、心悸、惡風(fēng)、盜汗六個項(xiàng)目具有統(tǒng)計學(xué)意義(P0.05)；3、多因素logistic回歸分析：篩選出年齡、PSQI分?jǐn)?shù)、晨起思睡和盜汗有統(tǒng)計學(xué)意義(P0.05)。結(jié)論：1、桂枝寤湯和桂枝寐湯對不寐具有明確的療效。2、桂枝寤湯和桂枝寐湯對PSQI分?jǐn)?shù)低,有晨起思睡、盜汗的老年失眠人群有更好的療效。
[Abstract]:Objective: through the clinical study of Guizhiwu decoction and Guizhimian decoction in the treatment of insomnia, the related factors related to the curative effect of Guizhiwu decoction and Guizhimian decoction in treating insomnia were summarized, and the composition and application of Guizhiwu decoction and Guizhimi decoction were improved continuously. Improve the effective rate of treatment of insomnia. Methods: selected from March 2015 to March 2016, at Ipoh Hospital in Perak, Malaysia, and in accordance with the 2008 edition of the guidelines for diagnosis and treatment of Common Diseases in traditional Chinese Medicine issued by the Chinese Association of traditional Chinese Medicine. The part of TCM disease and syndrome > the basis for diagnosis of insomnia, the third edition of the Chinese Classification and Diagnostic Standard of Mental Disorder, 2001, 100 cases of insomnia diagnosed by the standard of insomnia, the third edition of the 2001 edition of the Chinese Psychiatric Classification and Diagnostic Standard, According to the "guiding principles of Clinical Research of New Chinese Medicine (trial)" in 2002, "guiding principles of Clinical Research on Insomnia treated by New drugs of traditional Chinese Medicine" and the evaluation of clinical curative effect of insomnia promulgated by WHO, it will meet the diagnostic criteria and be included in the evaluation. The patients were divided into general effective group and ineffective group, and the effective rate was counted. Univariate statistics were carried out from general data and symptoms (including main symptoms and secondary symptoms), and then multivariate logistic regression analysis was carried out on significant single factors. Finally, statistically significant influencing factors were screened out. Results: according to the criteria of inclusion and exclusion, this study included 100 cases of complete cases, including 88 cases in the effective group, after collecting and sorting out the missing data or incomplete registration and missing cases. There were 12 cases in the ineffective group, 12 cases in the ineffective group, and the results showed that the total effective group and the ineffective group were in the age, There was statistical significance in three items of educational level and PSQI score: the statistical analysis of main symptoms and secondary symptoms: four major symptoms were single factor statistical analysis, the results indicated that the limit of falling asleep time was one hour, which had statistical significance (P 0.05). The results of univariate analysis of secondary symptoms showed that six items, such as thinking and sleeping early in the morning, inattention loss, mental retardation, palpitation, bad wind and night sweating, had statistical significance (P 0.05). Multivariate logistic regression analysis showed that age and age were determined by logistic regression analysis. There was significant difference between sleep and night sweating in the morning (P 0.05). Conclusion: 1, Guizhiwu decoction and Guizhimian decoction have definite curative effect on insomnia. Guizhiwu decoction and Guizhimian decoction have better effect on senile insomnia with low PSQI score, early morning sleep and night sweating.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2016
【分類號】：R256.23
，

本文編號：1970532