本文選題：補(bǔ)腎活血湯 + 卵巢功能減退��； 參考：《南京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過(guò)研究補(bǔ)腎活血湯治療腎虛肝郁型卵巢功能減退患者的臨床療效,闡明補(bǔ)腎活血湯對(duì)腎虛肝郁型卵巢功能減退的預(yù)防、治療作用,為臨床中醫(yī)藥治療卵巢功能減退提供理論依據(jù)。方法:收集2016年4月1日-2017年3月1日在江蘇省中西醫(yī)結(jié)合醫(yī)院婦科門診就診的41例辯證屬于腎虛肝郁型卵巢功能減退患者,隨機(jī)分為治療組21例和對(duì)照組20例。治療組予補(bǔ)腎活血湯治療,對(duì)照組予激素替代治療,治療3月后觀察兩組治療前后的臨床癥狀,血清性激素的變化,AFC,OVD及RI的變化,并且觀察兩組間的差異。結(jié)果:1.治療組綜合臨床療效為76%,對(duì)照組綜合臨床療效為70%,兩組間統(tǒng)計(jì)無(wú)顯著差異(P0.05)。治療組中醫(yī)癥候總有效率為81%,對(duì)照組中醫(yī)證候總有效率為75%,兩組組間統(tǒng)計(jì)無(wú)顯著差異(P0.05),兩組治療后與治療前均有顯著差異(P0.05)。治療組和對(duì)照組均能改善卵巢功能減退患者月經(jīng)不調(diào)與腎虛肝郁的臨床癥狀。2.兩組治療后FSH,FSH/LH水平下降、E2水平上升,與治療前均有顯著差異(P0.05);治療組LH水平下降,與治療前相比有顯著差異(P0.05),對(duì)照組LH水平有所下降,但與治療前無(wú)顯著差異(P0.05);治療后兩組組間LH、FSH比較有顯著差異(P0.05),E2,FSH/LH 無(wú)顯著差異(P0.05)。3.治療組和對(duì)照組AFC治療前后均有顯著差異(P0.05),OVD、RI治療前后均無(wú)顯著差異(P0.05);治療后兩組組間AFC、RI比較有顯著差異(P0.05),OVD比較無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:1.補(bǔ)腎活血湯可改善腎虛肝郁卵巢功能減退患者月經(jīng)不調(diào)等臨床癥狀,在治療腰膝酸軟方面明顯優(yōu)于對(duì)照組;2.補(bǔ)腎活血湯能降低血清FSH、LH、FSH/LH,升高E2,升高AFC,調(diào)整下丘腦-垂體-卵巢軸,促進(jìn)卵泡發(fā)育,改善卵巢血供,保護(hù)卵巢剩余組織,延緩卵巢功能衰退!
[Abstract]:Objective: to study the clinical effect of Bushen Huoxue decoction in treating ovarian dysfunction with kidney deficiency and liver depression, and to elucidate the preventive and therapeutic effects of Bushen Huoxue decoction on ovarian dysfunction due to kidney deficiency and liver depression. To provide a theoretical basis for the treatment of ovarian dysfunction with traditional Chinese medicine. Methods: from April 1, 2016 to March 1, 2017, 41 patients with ovarian dysfunction were randomly divided into treatment group (n = 21) and control group (n = 20). The treatment group was treated with Bushen Huoxue decoction and the control group was treated with hormone replacement therapy. After 3 months of treatment, the clinical symptoms, the changes of serum sex hormones and the changes of AFCU OVD and RI were observed, and the difference between the two groups was observed. The result is 1: 1. The comprehensive clinical curative effect of the treatment group was 76g and that of the control group was 70. There was no significant difference between the two groups (P 0.05). The total effective rate of TCM syndrome was 81 in the treatment group and 75 in the control group. There was no significant difference in statistics between the two groups (P 0.05). There was significant difference between the two groups after treatment and before treatment. Both the treatment group and the control group can improve the clinical symptoms of menstrual disorder and kidney deficiency and liver depression in patients with ovarian dysfunction. After treatment, the level of FSH / LH decreased and E2 level increased, and there was significant difference between the two groups in the level of LH, the level of LH in the treatment group was significantly lower than that in the control group, and the level of LH in the control group was lower than that in the control group, and the level of LH in the treatment group was significantly lower than that in the control group. However, there was no significant difference between the two groups before and after treatment (P 0.05), and there was no significant difference between the two groups (P 0.05). There were significant differences between the treatment group and the control group before and after AFC treatment. There was no significant difference between the two groups before and after treatment, and there was no significant difference between the two groups before and after treatment. There was no significant difference between the two groups before and after treatment (P 0.05), and there was no significant difference between the two groups before and after treatment (P 0.05). Conclusion 1. Bushen Huoxue decoction can improve the clinical symptoms such as irregular menstruation in patients with kidney deficiency and liver depression and ovarian dysfunction. It is superior to the control group in the treatment of waist and knee weakness. Bushen Huoxue decoction can reduce the serum FSHLH, increase E2, increase AFC, adjust hypothalamus-pituitary-ovary axis, promote follicular development, improve ovarian blood supply, protect ovarian surplus tissue, and delay the decline of ovarian function!
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R271.9

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