本文選題：絕經(jīng)前后諸證 + 腎陰虛��； 參考：《福建中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：通過觀察滋腎養(yǎng)巢方治療腎陰虛型絕經(jīng)前后諸證患者的臨床療效,以期尋求治療腎陰虛型絕經(jīng)前后諸證患者的良好的治療方法。方法：將60例腎陰虛型絕經(jīng)前后諸證的患者隨機分為治療組、對照組,每組各30例。其中治療組以口服中藥“滋腎養(yǎng)巢方”(導(dǎo)師經(jīng)驗方)為基礎(chǔ)方,并可隨癥加減,于就診當(dāng)日開始服用,1劑／d,早晚分服,以連續(xù)服用12周為一個療程；對照組口服替勃龍片(又名：紫竹愛維)2.50mg(1片),于就診當(dāng)日開始服用,每天固定同一時間服1次,以連續(xù)服用12周為一個療程。兩組均于治療前采集改良Kupperman評分量表、腎陰虛證中醫(yī)證候評分標(biāo)準(zhǔn)表、血清FSH、E2,且兩組均于治療12周后、停藥4周后分別采集改良Kupperman評分量表、腎陰虛證中醫(yī)證候評分標(biāo)準(zhǔn)表。觀察治療組及對照組在治療12周后的臨床療效以及停藥4周后的臨床療效維持情況。結(jié)果：1.滋腎養(yǎng)巢方及替勃龍均能改善腎陰虛型絕經(jīng)前后諸證患者的臨床癥狀,明顯降低患者的改良Kupperman評分量表(P0.05)及腎陰虛型中醫(yī)證候評分標(biāo)準(zhǔn)表(P0.05)。2.停藥4周后兩組的K評分差異有統(tǒng)計學(xué)意義(P0.05),停藥4周后兩組中醫(yī)證候評分差異有統(tǒng)計學(xué)意義(P0.05)。3.治療組在運用滋腎養(yǎng)巢方治療腎陰虛型絕經(jīng)前后諸證患者12周后的總有效率為93%,對照組在運用替勃龍治療腎陰虛型絕經(jīng)前后諸證患者12周后的總有效率為96.7%,經(jīng)過統(tǒng)計學(xué)的分析,治療組與對照組組間的差異無統(tǒng)計學(xué)意義(P0.05)。4.治療組在停藥4周后的總有效率為73.3%,對照組在停藥4周后的總有效率為23.3%,兩組組間的差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論：1.運用滋腎養(yǎng)巢方及替勃龍均能有效的治療腎陰虛型絕經(jīng)前后諸證患者,并且二者的近期臨床療效相當(dāng)。2.滋腎養(yǎng)巢方在停藥后的臨床療效維持方面優(yōu)于替勃龍。
[Abstract]:Objective: to observe the clinical effect of Zishen Yangchao recipe in treating the patients with kidney yin deficiency before and after menopause, in order to seek a good treatment method for the patients with kidney yin deficiency before and after menopause. Methods: 60 cases of kidney yin deficiency before and after menopause were randomly divided into treatment group and control group with 30 cases in each group. Among them, the treatment group took "Zishen Yangcai recipe" (tutor's experience prescription) as the basic prescription, and could be added or subtracted with the symptom. On the same day, the treatment group began to take 1 dose / d, taking it separately in the morning and evening, and taking it continuously for 12 weeks as a course of treatment. The control group was given tibolone tablets (also known as Zizhu Avignon 2.50 mg / L) on the day of treatment, taking it at the same time every day for 12 weeks as a course of treatment. Both groups collected the modified Kupperman scale before treatment, the scale of TCM syndromes of kidney-yin deficiency syndrome and the serum FSHE2. After 12 weeks of treatment, the two groups collected the modified Kupperman scale after 12 weeks of treatment, and the traditional Chinese medicine syndromes scale of kidney-yin deficiency syndrome. To observe the clinical effect of treatment group and control group after 12 weeks and the maintenance of clinical effect after 4 weeks. The result is 1: 1. Both Zishenyangchaofang and Tibolong could improve the clinical symptoms of patients with kidney yin deficiency before and after menopause, and significantly reduce the modified Kupperman scale (P0.05) and the scale of TCM syndromes of kidney-yin deficiency (P0.05J. 2). After 4 weeks of withdrawal, the difference of K score between the two groups was statistically significant (P 0.05), and the difference of TCM syndrome score between the two groups after 4 weeks of withdrawal was statistically significant (P 0.05). 3. The total effective rate of the treatment group was 933 after 12 weeks after the treatment of kidney yin deficiency menopause with Zishen Yangchao recipe, and the total effective rate of the control group was 96. 7% after 12 weeks of treatment of the kidney yin deficiency menopause. There was no significant difference between the treatment group and the control group (P 0.05. 4). The total effective rate was 73.3 in the treatment group and 23.3in the control group after 4 weeks. The difference between the two groups was statistically significant (P 0.05). Conclusion 1. Both Zishenyangchao recipe and tibolone can effectively treat the patients with kidney yin deficiency before and after menopause, and the short-term clinical efficacy of both is equivalent. 2. Zishen Yangcai recipe was superior to Tiblong in the maintenance of clinical efficacy after withdrawal of the drug.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R271.116

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