本文選題：頻發(fā)室性早搏 + 護(hù)心方��； 參考：《南京中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：觀察護(hù)心方對(duì)頻發(fā)室性早搏患者心率變異性的影響,探討頻發(fā)室性早搏患者應(yīng)用護(hù)心方的臨床治療效果,評(píng)價(jià)護(hù)心方治療頻發(fā)室性早搏的安全性,為護(hù)心方臨床治療頻發(fā)室性早搏提供數(shù)據(jù)支持。方法：本研究選取2015年6月至2016年6月在我院就診的100例患者進(jìn)行研究,隨機(jī)數(shù)字表法將患者分為治療組和對(duì)照組各50例。治療組采用護(hù)心方治療,對(duì)照組采用美托洛爾治療。觀察兩組治療前后連續(xù)R-R間期標(biāo)準(zhǔn)差(SDNN)、平均5分鐘R-R間期標(biāo)準(zhǔn)差(SDANN)、相鄰RR間期差的均方根(rMSSD)、相鄰RR間期差值超過50mm的心搏數(shù)占總心搏的百分比(PNN50)、QT離散度、治療效果、平均心率及不良反應(yīng)。結(jié)果：兩組患者性別、年齡等基線資料比較無差異(p0.05)；治療前兩組HRV的SDNN、SDANN、RMSSD和PNN50比較無差異(p0.05),治療后兩組HRV的SDNN SDANN、RMSSD和PNN50與同組治療前相比明顯增高(p0.05),治療組改善程度優(yōu)于對(duì)照組(p0.05)；兩組QTd和QTcd治療前比較無差異(p0.05),兩組治療后的QTd和QTcd與同組治療前相比均較下降(p0.05),對(duì)照組改善程度不及治療組(p0.05)；對(duì)照組臨床治療有效率為70.00%,治療組臨床治療有效率為88.00%,組間比較有差異(p0.05)；兩組患者治療前后組內(nèi)、組間平均心率變化比較均無差異(p0.05)；對(duì)照組與治療組患者副反應(yīng)發(fā)生率分別為18.00%和4.00%,組間比較有差異(p0..05)。結(jié)論：頻發(fā)室性早搏患者應(yīng)用護(hù)心方顯效,可以有效延長(zhǎng)心率變異性、有效降低QT離散度,并且臨床療效確切,對(duì)患者心率作用不大,有效降低了頻發(fā)室性早搏患者藥物治療過程中的不良情況的發(fā)生,臨床應(yīng)用及研究?jī)r(jià)值較高。
[Abstract]:Objective: to observe the effect of Huxin recipe on heart rate variability in patients with frequent ventricular premature beats, to explore the clinical therapeutic effect of Huxin recipe in patients with frequent ventricular premature beats, and to evaluate the safety of Huxin recipe in treating frequent ventricular premature beats. To provide data support for the clinical treatment of frequent ventricular premature beats. Methods: 100 patients in our hospital from June 2015 to June 2016 were selected and randomly divided into treatment group (n = 50) and control group (n = 50). The treatment group was treated with Huxin recipe and the control group with metoprolol. The continuous R-R interval standard deviation before and after treatment was observed in the two groups. The mean 5-minute R-R interval standard deviation was observed. The RMSSDN of the adjacent RR interval difference was measured. The percentage of the beat number of the adjacent RR interval over 50mm in the total cardiac beat was measured. Mean heart rate and adverse reactions. Results: two groups of patients gender, Before treatment, there was no difference between the two groups in HRV and PNN50. After the treatment, the SDNN SDANNN HRV and PNN50 of the two groups were significantly higher than those of the same group (P 0.05), the improvement of the treatment group was better than that of the control group (p0.05), QTd and PNN50 of the two groups were significantly higher than that of the control group (P 0.05), the improvement of the two groups was better than that of the control group (P < 0.05), and that of the two groups was significantly higher than that of the control group (P < 0.05). There was no difference in QTcd before and after treatment. The QTd and QTcd of the two groups were lower than those of the same group before treatment, the improvement degree of the control group was not as good as that of the treatment group, the effective rate of clinical treatment in the control group was 70. 00g and the effective rate of clinical treatment in the treatment group was 88.000.The effective rate of the treatment group was 88. 00%, while the improvement degree of the control group was less than that of the control group (P 0. 05). There was significant difference between the two groups before and after treatment. There was no significant difference in the mean heart rate between the two groups (p 0.05), and the incidence of side effects in the control group and the treatment group was 18.00% and 4.00, respectively, and there was significant difference between the two groups (p 0. 05). Conclusion: the application of Huxinfang in patients with frequent ventricular premature beats can effectively prolong heart rate variability and reduce QT dispersion. It can effectively reduce the incidence of adverse events in the course of drug therapy in patients with frequent ventricular premature beats, and has high clinical application and research value.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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