本文選題：益氣養(yǎng)陰潤腸湯 + 老年功能性便秘�。� 參考：《河南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:通過與聚乙二醇4000散劑(商品名:福松)做對照,觀察益氣養(yǎng)陰潤腸湯對老年功能性便秘患者的臨床癥狀改善情況,研究其治療效果,初步探討其治療機(jī)制,由此進(jìn)一步評價益氣養(yǎng)陰潤腸湯的安全性、有效性及遠(yuǎn)期療效性,進(jìn)而為臨床應(yīng)用提供有力的科學(xué)依據(jù)。方法:選擇2015年1月至2016年1月就診于河南中醫(yī)藥大學(xué)第二附屬醫(yī)院肛腸科,符合氣陰兩虛型老年便秘患者60例,按每個病人就診時生成的就診號,制成EXCEL表,運用隨機(jī)數(shù)字表分組法,分為治療組30例和對照組30例。治療組運用益氣養(yǎng)陰潤腸湯,對照組運用福松。兩組均連續(xù)治療一個月,治療期間詳細(xì)記錄兩組患者臨床癥狀變化情況及有無不良反應(yīng)。治療結(jié)束后,對兩組治療前后臨床總療效、臨床癥狀評分變化情況及停藥2個月后的復(fù)發(fā)情況,采用SPSS19.0統(tǒng)計軟件,經(jīng)統(tǒng)計學(xué)處理來評估分析。結(jié)果:(1)在改善臨床總療效方面:治療組總有效率為93.33%,總有效率為73.33%,經(jīng)統(tǒng)計學(xué)分析,兩組患者總有效率比較差異明顯(P0.05),具有統(tǒng)計學(xué)意義,說明兩組在改善臨床總療效方面,治療組優(yōu)于對照組。(2)在改善臨床總癥狀積分方面:兩組患者分別治療后,臨床總癥狀積分與治療前比較,均有顯著性差異(P0.05),說明兩組均能改善老年功能性便秘患者的臨床總癥狀;治療后兩組總癥狀積分差值比較(P0.05),具有統(tǒng)計學(xué)意義,說明治療組在改善臨床總癥狀方面明顯優(yōu)于對照組。(3)在改善臨床主要癥狀積分方面:兩組患者分別治療后,排便間隔時間、排便時間、大便性狀、排便困難程度積分與治療前比較,均有顯著性差異(P0.05),說明兩組均能改善老年功能性便秘患者的臨床主要癥狀;治療后兩組主要癥狀積分差值比較(P0.05),具有統(tǒng)計學(xué)意義,說明治療組在改善臨床主要癥狀方面明顯優(yōu)于對照組。(4)在改善臨床次要癥狀積分方面:兩組患者分別治療后,神疲懶言、氣短乏力、頭暈耳鳴、潮熱盜汗積分與治療前比較,均有顯著性差異(P0.05),說明兩組均能改善老年功能性便秘患者的臨床次要癥狀;治療后兩組次要癥狀積分差值比較,除氣短乏力積分差值P0.05外,其余P均0.05,具有統(tǒng)計學(xué)意義,說明兩組在治療氣短乏力方面,治療效果相當(dāng),在改善神疲懶言、頭暈耳鳴、潮熱盜汗方面,治療組明顯優(yōu)于對照組。(5)在復(fù)發(fā)率方面:治療結(jié)束后隨訪2個月,結(jié)果治療組復(fù)發(fā)率3.57%,對照組復(fù)發(fā)率22.73%,兩組復(fù)發(fā)率比較差異具有統(tǒng)計學(xué)意義(P0.05),表明治療組遠(yuǎn)期療效明顯優(yōu)于對照組。結(jié)論:導(dǎo)師經(jīng)驗方益氣養(yǎng)陰潤腸湯治療氣陰兩虛型老年功能性便秘,在改善臨床總療效、臨床總癥狀、臨床主要癥狀、臨床次要癥狀及復(fù)發(fā)率方面,其療效明顯優(yōu)于對照組聚乙二醇4000散劑(福松),值得在臨床中推廣應(yīng)用。
[Abstract]:Objective: to observe the improvement of clinical symptoms of Yiqi Yangyin Runchang decoction in elderly patients with functional constipation by comparing with polyethylene glycol 4000 powder (commodity name: Fusong), to study its therapeutic effect and to explore its therapeutic mechanism. Therefore, the safety, effectiveness and long-term curative effect of Yiqi Yangyin Runchang decoction were further evaluated, and the scientific basis for clinical application was provided. Methods: from January 2015 to January 2016, 60 elderly constipation patients who were admitted to Henan University of traditional Chinese Medicine at the second affiliated Hospital of Henan University of traditional Chinese Medicine were selected and made into EXCEL table according to the number of patients with constipation due to deficiency of Qi and Yin. We divided the treatment group (30 cases) into treatment group (30 cases) and control group (30 cases). The treatment group was treated with Yiqi Yangyin Runchang decoction and the control group with Fusong. The two groups were treated continuously for one month. The clinical symptoms and adverse reactions of the two groups were recorded in detail. After the treatment, the total curative effect, the clinical symptom score and the relapse after 2 months were evaluated and analyzed by SPSS19.0 software. Results: the total effective rate of the treatment group was 93.33, and the total effective rate was 73.33. By statistical analysis, the total effective rate of the two groups was significantly different from that of the two groups (P 0.05), which showed that the two groups had statistical significance in improving the total clinical efficacy. The treatment group was superior to the control group in improving the total clinical symptom score: after the two groups were treated separately, the clinical total symptom score was compared with that before treatment. There were significant differences between the two groups, indicating that the two groups could improve the total clinical symptoms of the elderly patients with functional constipation, and the difference of the total symptom scores between the two groups was statistically significant after treatment. It shows that the treatment group is obviously superior to the control group in improving the total clinical symptoms.) in improving the clinical main symptom score, the two groups of patients after treatment, defecation interval time, defecation character, The scores of defecation difficulty were significantly different from those before treatment (P 0.05), which indicated that the two groups could improve the main clinical symptoms of senile functional constipation, and the difference between the two groups was statistically significant. It shows that the treatment group is obviously superior to the control group in improving the main clinical symptoms.) in improving the clinical secondary symptom score: after treatment, the patients in the two groups were compared with those before treatment in terms of mental fatigue, asthenia, dizziness and tinnitus, hot flashes and night sweats. There were significant differences between the two groups (P 0.05), which indicated that the two groups could improve the clinical secondary symptoms of the elderly patients with functional constipation, the difference between the two groups in the score of secondary symptoms was significant, except for the difference of asthenia and asthenia (P0.05), the other two groups had statistical significance. The results showed that the two groups had the same therapeutic effect in the treatment of asthenia and asthenia. The treatment group was obviously superior to the control group in the recurrence rate in terms of improving the tired speech, dizziness and tinnitus, and hot tide and night sweating.) at the end of the treatment, the treatment group was followed up for 2 months. Results the recurrence rate was 3.57 in the treatment group and 22.73 in the control group. The difference of the recurrence rate between the two groups was statistically significant (P 0.05), which indicated that the long-term curative effect of the treatment group was obviously better than that of the control group. Conclusion: the treatment of functional constipation of senile patients with deficiency of Qi and yin by the tutor's experience prescription "Yiqi Yangyin Runchang decoction" can improve the total clinical curative effect, clinical symptoms, main clinical symptoms, clinical secondary symptoms and recurrence rate. Its curative effect is obviously superior to that of the control group, which is worth popularizing in clinic.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R256.35

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