健脾益腎活血泄?jié)岱ㄖ委烠KD2-4期患者血脂異常的臨床研究
發(fā)布時(shí)間：2018-05-21 08:24
本文選題：健脾益腎活血泄?jié)岱?/strong> + CKD�。� 參考：《河南中醫(yī)藥大學(xué)》2016年碩士論文
【摘要】：目的:按照慢性腎臟病(CKD)一般常規(guī)治療的前提下,本實(shí)驗(yàn)依據(jù)健脾益腎活血泄?jié)岱▽β阅I臟病(CKD)2-4期患者血脂異常進(jìn)行研究,通過治療組及對照組的血脂水平、腎功能、中醫(yī)癥狀積分的前后差異及變化趨勢,更深一步地探討此法對于血脂異常的影響。方法:實(shí)驗(yàn)中進(jìn)行臨床觀察的60例患者均來自于河南中醫(yī)藥大學(xué)門診或者住院病人,將此60例病人按照隨機(jī)表分配為健脾益腎活血泄?jié)嶂委熃M與血脂康膠囊組,每組30例患者,連續(xù)治療12周,兩個(gè)小組的基礎(chǔ)治療均采用常規(guī)方式,如降低血糖、控制血壓、低蛋白含量的優(yōu)質(zhì)飲食如進(jìn)食少量的牛奶、雞蛋等。治療組患者口服健脾益腎活血泄?jié)岱?1劑/日(約400ml,早晚分兩次服用);對照組患者口服血脂康膠囊(2粒/次,2次/天),在一觀察周期內(nèi),將中醫(yī)癥狀積分、血脂實(shí)驗(yàn)室指標(biāo)(HDL、LDL、TC、TG)、腎功能(Scr、Bun)的前后變化進(jìn)行比較和記錄,系統(tǒng)觀察這些指標(biāo)變化與服用中藥的關(guān)系。結(jié)果:1.治療組與對照組均能降低血脂及肌酐、尿素氮水平,治療組在降低TC、TG、Scr、Bun方面優(yōu)于對照組(P0.05),在降低LDL-C和升高HDL-C方面與對照組相當(dāng)(P0.05)。2.治療組在改善中醫(yī)臨床癥狀方面(如腹脹、食少等),療效優(yōu)于對照組(P0.05)。結(jié)論:本實(shí)驗(yàn)初步證實(shí)了健脾益腎活血泄?jié)岱▽τ诼阅I臟病(CKD)2-4期患者血脂異常的治療是有效的,在改善患者腎功能、中醫(yī)癥狀方面有一定療效。
[Abstract]:Objective: according to the general routine treatment of chronic kidney disease (CKD), this experiment was based on the method of invigorating spleen, tonifying the kidney and activating blood circulation, to study the abnormal blood lipids in patients with chronic kidney disease at stage 2-4, and to study the level of blood lipid and renal function in the treatment group and control group. The difference and change trend of TCM symptom score, and the effect of this method on dyslipidemia were further discussed. Methods: all of the 60 cases of clinical observation were from outpatients or inpatients of Henan University of traditional Chinese Medicine. According to the random list, the patients were divided into two groups: the treatment group of invigorating spleen, tonifying kidney, activating blood circulation and discharging turbidity, and the group of Xuezhikang capsule, with 30 patients in each group. After 12 weeks of continuous treatment, both groups were treated in routine ways, such as lowering blood sugar, controlling blood pressure, and eating low-protein quality diets such as eating small amounts of milk and eggs. The patients in the treatment group were given one dose per day (about 400ml, twice in the morning and evening) of Jianpi Yishen Huoxue Xiezhuo decoction, while the control group patients were given 2 capsules of Xuezhikang capsule twice a time per day. In one observation period, the patients in the control group were integrated with the symptoms of traditional Chinese medicine. The changes of serum lipids in the laboratory were compared and recorded before and after HDL LDLT TGG and Scr-Bunn. The relationship between the changes of these indexes and the administration of traditional Chinese medicine was observed systematically. The result is 1: 1. The levels of serum lipids, creatinine and urea nitrogen in the treatment group and the control group were lower than those in the control group. The treatment group was superior to the control group in reducing TCG-TGG Scr-Bun, and in decreasing LDL-C and increasing HDL-C. The curative effect of the treatment group was better than that of the control group in improving the clinical symptoms of traditional Chinese medicine (such as abdominal distension, less food and so on). Conclusion: the method of invigorating spleen, tonifying kidney, activating blood circulation and discharging turbidity is effective in the treatment of chronic kidney disease (CKD) 2-4 patients with abnormal blood lipids. It is effective in improving the renal function of patients and in improving the symptoms of traditional Chinese medicine.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R277.5
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 陳燁;朱春玲;嚴(yán)瑞;劉曉霞;宋文玉;;山茱萸對腎間質(zhì)纖維化的保護(hù)作用及機(jī)制研究[J];天然產(chǎn)物研究與開發(fā);2015年11期
2 鐘周;周鴻圖;胡志希;梁昊;范建民;;140味降脂中藥治療高脂血癥的用藥規(guī)律分析[J];湖南中醫(yī)藥大學(xué)學(xué)報(bào);2015年01期
3 孫春曉;郭兆安;;慢性腎臟病血脂代謝紊亂的影響因素及其機(jī)制的研究進(jìn)展[J];中國中西醫(yī)結(jié)合腎病雜志;2014年06期
4 袁帆;張全華;冉子伯;;降脂類中藥組方治療高脂血癥臨床觀察[J];西部中醫(yī)藥;2014年05期
5 張怡;周彥;;中藥配方顆粒劑用于高脂血癥臨床觀察[J];遼寧中醫(yī)雜志;2014年03期
6 屠慶祝;李艷萍;;中藥治療高脂血癥的用藥規(guī)律[J];山東中醫(yī)雜志;2014年03期
7 李嵐生;;化痰降脂活血中藥治療高脂血癥臨床研究[J];中醫(yī)臨床研究;2013年22期
8 王偉偉;徐貴發(fā);張魯燕;郝小蕊;;中年男性飲酒與血脂異常關(guān)系的病例-對照研究[J];衛(wèi)生研究;2013年03期
9 宋春俠;暴宏伶;時(shí)菁靜;;繁木瀉土湯治療高脂血癥的臨床研究[J];中國實(shí)驗(yàn)方劑學(xué)雜志;2013年06期
10 馬俊杰;張靜靜;周春祥;;藥浴對慢性腎臟�、笃诎楦咧Y患者血脂水平的影響[J];護(hù)理學(xué)報(bào);2013年03期
，本文編號：1918461
本文鏈接：http://sikaile.net/zhongyixuelunwen/1918461.html
最近更新
教材專著
