本文選題：糖尿病 + 血脂異常��； 參考：《遼寧中醫(yī)藥大學》2016年碩士論文

【摘要】：目的:探尋糖尿病大血管病變的誘發(fā)因素,為中西醫(yī)臨床治療糖尿病大血管病變提供理論依據(jù)與幫助。資料與方法:收集2014年3月-2015年3月就診于遼寧中醫(yī)藥大學附屬醫(yī)院內(nèi)分泌科2型糖尿病患者210例,其中符合糖尿病大血管病變診斷標準的患者有70例設為糖尿病大血管病變組,另設70例單純2型糖尿病(T2DM)組為對照組。收集患者的一般臨床資料(年齡、性別、病程等)以及實驗室指標。對比分析糖尿病并發(fā)大血管病變組患者與單純2型糖尿病組患者在年齡、病程、糖化血紅蛋白(Hb A1C)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、總膽固醇(TC)、甘油三酯(TG)、體重指數(shù)(BMI)、腰圍(WC)、尿酸(UA)的差異,以此探尋糖尿病大血管病變的誘發(fā)因素。采用SPSS 17.0統(tǒng)計軟件進行統(tǒng)計,組間例數(shù)比采用WPS 2016建立直方圖。結(jié)果:1、糖尿病大血管病變組患者糖化血紅蛋白平均值為(9.12±1.85)mmol/l,單純2型糖尿病組平均值為(8.50±1.76)mmol/l,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05)。2、糖尿病大血管病變組患者TC平均值為(5.42±1.54)mmol/l,單純2型糖尿病組為(4.98±0.94)mmol/l,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05);大血管病變組患者LDL-C平均值為(3.37±1.09)mmol/l,單純2型糖尿病組為(3.05±0.72)mmol/l,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05);大血管病變組患者HDL-C平均值為(1.08±0.25)mmol/l,單純2型糖尿病組為(1.17±0.25)mmol/l,大血管病變組低于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05);大血管病變組患者TG平均值為(2.05±0.89)mmol/l,單純2型糖尿病組為(1.75±0.76)mmol/l,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05)。3、糖尿病大血管病變組患者血尿酸平均值為(338.20±89.63)μmol/l,單純2型糖尿病組為(309.30±74.54)μmol/l,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05)。4、糖尿病大血管病變組患者BMI平均值為(26.01±3.87)kg/m2,單純2型糖尿病組為(24.43±2.98)kg/m2,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.01);大血管病變組患者WC平均值為(90.91±10.41)cm,單純2型糖尿病組為(87.03±8.50)cm,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05)。5、糖尿病大血管病變組患者年齡平均值為(60.89±9.71)歲,單純2型糖尿病組年齡平均值為(57.37±10.32)歲,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05);糖尿病大血管病變組患者病程平均值為(10.30±3.59)年,單純2型糖尿病組為(8.94±3.56)年,大血管病變組高于單純2型糖尿病組,差異具有統(tǒng)計學意義(P0.05)。結(jié)論:1、糖尿病大血管病變與高血糖、高血脂、高尿酸、肥胖、年齡等因素相關。2、隨著血糖、LDL-C、TC、TG、血尿酸的升高,年齡的增長、病程的延長糖尿病大血管病變程度加重。3、高血糖、高血脂、高尿酸、肥胖隸屬于中醫(yī)學痰濁、熱毒等毒邪范疇,所以中醫(yī)以益氣養(yǎng)陰、解毒化瘀等方法可以防治糖尿病大血管病變。
[Abstract]:Objective: To explore the inducing factors of diabetic macroangiopathy, and to provide theoretical basis and help for the clinical treatment of diabetic macrovascular disease in Chinese and Western medicine. Data and methods: 210 patients with type 2 diabetes in Department of Endocrinology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, March 2014, which were diagnosed in the Department of Endocrinology, Liaoning University of Traditional Chinese Medicine, were in line with the diagnosis of diabetic macrovascular disease. There were 70 patients with diabetic macroangiopathy and 70 patients with type 2 diabetes mellitus (T2DM) as control group. The general clinical data (age, sex, course of disease, etc.) and laboratory indexes were collected. The age, course of disease, glycosylated blood red in patients with diabetes complicated with large vessel disease and type 2 diabetes mellitus were compared and analyzed. Protein (Hb A1C), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total cholesterol (TC), triglyceride (TG), body mass index (BMI), waist circumference (WC), and uric acid (UA), in order to explore the inducing factors of diabetic macroangiopathy. The statistical software of SPSS 17 was used to establish a histogram compared with WPS 2016. Results: 1, sugar The mean value of glycosylated hemoglobin was (9.12 + 1.85) mmol/l in the patients with large vascular disease, and the average value of the simple type 2 diabetes group was (8.50 + 1.76) mmol/l, the large vascular lesion group was higher than that of the simple type 2 diabetes group. The difference was statistically significant (P0.05).2. The mean value of TC in the diabetic macroangiopathy group was (5.42 + 1.54) mmol/l, and the only type of diabetes alone was of type 2 diabetes. The disease group was (4.98 + 0.94) mmol/l, the large vascular lesion group was higher than the simple type 2 diabetes group, the difference was statistically significant (P0.05), the average value of LDL-C in the large vessel disease group was (3.37 + 1.09) mmol/l, the simple type 2 diabetes group was (3.05 + 0.72) mmol/l, and the large vessel disease group was higher than the only type 2 diabetes group, the difference was statistically significant (P0.05). The mean value of HDL-C in the patients with vascular disease was (1.08 + 0.25) mmol/l, the group of simple type 2 diabetes was (1.17 + 0.25) mmol/l, the group of large vessel disease was lower than that of type 2 diabetes group, the difference was statistically significant (P0.05); the mean value of TG in the group of large vessel disease was (2.05 + 0.89) mmol/l, and the group of simple type 2 diabetes mellitus was (1.75 + 0.76) mmol/l, large vascular disease. The group was higher than the simple type 2 diabetes group, the difference was statistically significant (P0.05).3, the mean value of the blood uric acid in the diabetic macroangiopathy group was (338.20 + 89.63) mu mol/l, the simple type 2 diabetes group was (309.30 + 74.54) mol/l, the large vascular disease group was higher than that of the simple type 2 diabetes group, the difference was statistically significant (P0.05).4, diabetic macroangiopathy The average value of BMI in the variable group was (26.01 + 3.87) kg/m2, the group of simple type 2 diabetes was (24.43 + 2.98) kg/m2, the large vascular lesion group was higher than that of the simple type 2 diabetes group, the difference was statistically significant (P0.01); the mean value of WC in the large vessel disease group was (90.91 + 10.41) cm, and the group of simple type 2 diabetes mellitus was (87.03 + 8.50) cm, and the large vessel lesion group was higher than pure 2. The difference was statistically significant (P0.05).5, the age average of the diabetic macroangiopathy group was (60.89 + 9.71) years, the average age of the simple type 2 diabetes group was (57.37 + 10.32) years old, the large vascular disease group was higher than the simple type 2 diabetes group, the difference was statistically significant (P0.05); the diabetic macroangiopathy group patient's disease The average range was (10.30 + 3.59) years, and the group of simple type 2 diabetes was (8.94 + 3.56) years. The large vascular disease group was higher than that of the simple type 2 diabetes group. The difference was statistically significant (P0.05). Conclusion: 1, diabetic macroangiopathy is related to hyperglycemia, hyperlipidemia, high uric acid, high uric acid, obesity, age and other factors related to.2, with the increase of blood glucose, LDL-C, TC, TG, and blood uric acid, year The growth of age, the prolongation of the course of the disease, the degree of diabetic macrovascular disease aggravates.3, hyperglycemia, hyperlipidemia, high uric acid, and obesity is subordinate to the category of phlegm and heat toxin in traditional Chinese medicine. So the Chinese medicine can prevent and cure the major vascular lesions of diabetes with the methods of nourishing qi and nourishing Yin, detoxifying and removing stasis.

【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259
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本文編號：1896637