本文選題：新生兒 + 抗生素相關(guān)性腹瀉�。� 參考：《湖南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的觀察自擬白術(shù)散治療新生兒抗生素相關(guān)性腹瀉(脾虛證)的臨床療效,為其臨床運用提供理論實踐依據(jù)。方法采用隨機、單盲、對照的方法,將60例新生兒抗生素相關(guān)性腹瀉(脾虛證)的患兒隨機分為自擬白術(shù)散治療組30例和西藥對照組30例,連續(xù)3天為一個療程,根據(jù)腹瀉改善情況連續(xù)觀察1-2個療程,比較治療前和用藥3天后兩組患兒臨床疾病療效、脾虛證癥狀積分的變化,比較2組腹瀉治愈天數(shù),安全性指標變化情況并觀察用藥中有無不良反應(yīng),探討自擬白術(shù)散在臨床運用的優(yōu)勢。結(jié)果(1)治療組與對照組腹瀉持續(xù)時間的比較:治療組腹瀉持續(xù)時間為3.900±1.269天,對照組腹瀉持續(xù)時間4.800±1.215天,差異明顯,有統(tǒng)計學(xué)意義。(2)治療組與對照組兩組之間治療療效的比較:治療組30例中臨床痊愈9例,顯效11例,有效10例,無效0例,總有效率100%。對照組30例其中臨床痊愈5例,顯效6例,有效16例,無效3例,總有效率90%。治療組較對照組療效好(Z=-2.352,P=0.0190.05)有統(tǒng)計學(xué)意義。(3)治療后兩組脾虛證癥狀積分均有下降,治療組下降的幅度更大。結(jié)論自擬白術(shù)散佐治新生兒AAD(脾虛證)起效快,療效更好,對患兒癥狀和體征的改善優(yōu)于對照組,且無明顯副作用。
[Abstract]:Objective to observe the clinical effect of self-made Atractylodes powder in the treatment of neonatal antibiotic-associated diarrhea (spleen deficiency syndrome) and to provide theoretical and practical basis for its clinical application. Methods 60 newborns with antibiotic associated diarrhea (spleen deficiency syndrome) were randomly divided into two groups: the treatment group (n = 30) and the control group (n = 30). According to the improvement of diarrhea, 1-2 courses of treatment were observed continuously, the curative effect of clinical diseases and the symptom score of spleen deficiency syndrome were compared between the two groups before treatment and 3 days after treatment, and the days of cure of diarrhea were compared between the two groups. The changes of safety indexes and the adverse reactions were observed, and the advantages of self-made Atractylodes macrocephala powder in clinical application were discussed. Results 1) the duration of diarrhea was 3.900 鹵1.269 days in the treatment group and 4.800 鹵1.215 days in the control group. Comparison of the therapeutic effects between the treatment group and the control group: in the treatment group, 9 cases were clinically cured, 11 cases were markedly effective, 10 cases were effective, 0 cases were ineffective, and the total effective rate was 100%. In the control group, 5 cases were clinically cured, 6 cases were markedly effective, 16 cases were effective, 3 cases were ineffective, and the total effective rate was 90 cases. The curative effect of the treatment group was better than that of the control group. There was a significant difference between the treatment group and the control group (0.0190.05).) after treatment, the symptom scores of spleen deficiency in the two groups were all decreased, and the amplitude of the decrease in the treatment group was even greater than that in the control group. Conclusion the treatment of AAD (spleen deficiency syndrome) by self-made Atractylosam powder is more effective and better than that of the control group, and there is no obvious side effect in the treatment of AAD (spleen deficiency Syndrome) in the control group.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R272

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