本文選題：溫中養(yǎng)胃合劑 + 臨床觀察�。� 參考：《成都中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：研究目的：本研究通過觀察溫中養(yǎng)胃合劑(綿陽市中醫(yī)醫(yī)院院內(nèi)制劑)對功能性消化不良(functional dyspepsia, FD)寒熱錯雜證患者的總體療效及臨床癥狀改善情況,初步探討溫中養(yǎng)胃合劑治療FD寒熱錯雜證患者的療效、復(fù)發(fā)率、安全性等,為臨床上運(yùn)用及今后進(jìn)一步研究提供依據(jù)。研究方法：本研究選取綿陽市中醫(yī)醫(yī)院脾胃科門診中符合納入標(biāo)準(zhǔn)的60例患者,隨機(jī)分為治療組和對照組。治療組30例,予溫中養(yǎng)胃合劑口服;對照組30例,予多潘立酮(嗎丁啉)+奧美拉唑腸溶膠囊口服,每周復(fù)診1次,連續(xù)治療4周。在治療期間兩組均不允許服用其它藥物,勞逸適度,并忌飲咖啡、濃茶,禁食辛辣刺激、冷硬、油膩之物等。主要觀察項目為臨床有效率、中醫(yī)癥狀積分、復(fù)發(fā)率等指標(biāo),用SPSS21.0軟件對數(shù)據(jù)統(tǒng)計分析,做出相關(guān)臨床療效判定。研究結(jié)果：1.臨床有效率比較：治療組總有效率為89.66%,對照組總有效率為79.31%。對兩組有效率進(jìn)行秩和檢驗,組間差異無統(tǒng)計學(xué)意義(PO.05)。2.中醫(yī)癥狀療效比較： (1)組內(nèi)比較：治療組治療前后單項中醫(yī)癥狀積分比較差異均有統(tǒng)計學(xué)意義(P0.05)；對照組治療前后單項中醫(yī)癥狀積分在大便稀溏、遇冷加重、肢體發(fā)涼上差異無統(tǒng)計學(xué)意義(P＞0.05),其余癥狀積分上差異具有統(tǒng)計學(xué)意義(P0.05)。(2)組間比較：治療組與對照組治療后中醫(yī)癥狀積分在胃脘部脹滿、胃脘疼痛、口干口苦、大便稀溏、遇冷加重、肢體發(fā)涼癥狀上差異均具有統(tǒng)計學(xué)意義(P0.05),尤其在改善胃脘部脹滿不適、大便稀溏、遇冷加重、肢體發(fā)涼這幾項癥狀積分上具有顯著性差異(P0.01)。3.復(fù)發(fā)率比較：治療結(jié)束后隨訪2個月,對照組復(fù)發(fā)14例,治療組復(fù)發(fā)6例,經(jīng)統(tǒng)計分析,兩組比較差異具有統(tǒng)計學(xué)意義(P0.05)結(jié)論：溫中養(yǎng)胃合劑能有效治療FD(寒熱錯雜證)患者,總體有效率與多潘立酮片+奧美拉唑腸溶膠囊組相當(dāng),但在改善FD患者某些臨床癥狀、減少復(fù)發(fā)率等方面治療組優(yōu)于對照組。溫中養(yǎng)胃合劑治療FD(寒熱錯雜證)療效顯著,且復(fù)發(fā)率小,服藥簡單,值得進(jìn)一步研究和臨床推廣。
[Abstract]:Objective: to observe the general curative effect and the improvement of clinical symptoms of wenzhong Yangwei mixture (Mianyang traditional Chinese Medicine Hospital) on patients with functional dyspepsia (FDD). To explore the curative effect, recurrence rate and safety of Wenzhong Yangwei mixture in the treatment of FD patients with mixed cold and heat, and to provide the basis for clinical application and further study in the future. Methods: 60 patients in the outpatient department of spleen and stomach of Mianyang traditional Chinese Medicine Hospital were randomly divided into treatment group and control group. 30 cases in the treatment group were treated with Wenzhong Yangwei mixture and 30 cases in the control group were treated with domperidone (morpholine) omeprazole enteric capsule once a week for 4 weeks. During the treatment period, both groups were not allowed to take other drugs, moderate labor, and avoid coffee, strong tea, fasting spicy stimulation, cold and hard, greasy, and so on. The main observation items were clinical effective rate, TCM symptom score, recurrence rate and so on. The data were statistically analyzed by SPSS21.0 software, and the related clinical curative effect was judged. The result of the study was: 1. The total effective rate was 89.66 in the treatment group and 79.31 in the control group. The effective rate of the two groups was tested by rank sum test, and there was no significant difference between the two groups. Comparison of Therapeutic effects of TCM symptoms: comparison of TCM symptom scores before and after treatment in treatment group: there were significant differences in the scores of single TCM symptoms before and after treatment in the treatment group; in the control group, the scores of symptoms of single TCM before and after treatment were in loose stools, which did not increase as expected. There was no significant difference on the upper part of extremity hair and cooling (P > 0.05), but there was significant difference in the other symptom scores between the two groups: after treatment, the scores of TCM symptoms in the treatment group and the control group were full of stomach distention, epigastric pain, dry mouth and bitter mouth, and loose stool. There were significant differences in the symptoms of extremity cooling, especially in the improvement of stomach distention, loose stool, not like expected aggravation. There was significant difference in the scores of the symptoms of extremity hair and cooling (P 0.01g. 3), especially in the improvement of stomach distension and discomfort, loose stools, not like the expected aggravation, and there was significant difference in the scores of the symptoms of extremity cooling. Comparison of recurrence rate: 14 cases in control group and 6 cases in treatment group were followed up for 2 months after treatment. Statistical analysis showed that the difference between the two groups was statistically significant (P 0.05). Conclusion: Wenzhong Yangwei mixture can effectively treat FDD patients. The overall effective rate was similar to that of omeprazole enteric-coated capsule group, but the treatment group was superior to the control group in improving some clinical symptoms and reducing recurrence rate of FD patients. The effect of Wenzhong Yangwei mixture in the treatment of FDs is remarkable, and the recurrence rate is small, and the medication is simple, so it is worth further study and clinical popularization.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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