反復(fù)體外受精—胚胎移植失敗證素特點及其與病史相關(guān)性的研究
本文選題:反復(fù)體外受精-胚胎移植失敗 + 證素; 參考:《山東中醫(yī)藥大學(xué)》2016年碩士論文
【摘要】:目的:本文通過對反復(fù)體外受精-胚胎移植失敗患者的證素分布特點及其與年齡、不孕病程、流產(chǎn)次數(shù)、不孕相關(guān)病史的相關(guān)性研究,初步探討證形成的病理基礎(chǔ),以期更好地指導(dǎo)本病在臨床上的防與治。方法:采用臨床流行病學(xué)調(diào)研的方法,對92例反復(fù)IVF-ET失敗患者的個人基本信息及中醫(yī)證素四診信息采集,運用證素積分法及統(tǒng)計方法對采集信息進(jìn)行數(shù)據(jù)分析,明確證素分布特點,以及其與年齡、不孕病程、流產(chǎn)次數(shù)、既往病史的關(guān)系。結(jié)果:1.反復(fù)體外受精-胚胎移植失敗常見病位證素為:腎、肝、胞宮、脾、心,其中證素腎共88例,占95.7%,占比最大,胞宮、肝次之,分別共80例、79例,分別占87.0%、85.9%。常見的病性證素為陰虛、血瘀、氣滯、濕、痰、陽虛、氣虛,其中證素血瘀共90例,占97.8%,占比最大,陰虛、氣滯次之,分別共85例、71例,分別占92.4%、77.2%。2.證素特點與年齡、不孕病程、流產(chǎn)次數(shù)具有相關(guān)性,具體如下:年齡越大,腎臟的功能失調(diào)表現(xiàn)以及陰虛的病機變化越突出;不孕病程越長,腎臟的功能失調(diào)表現(xiàn)以及氣滯的病機變化越突出;流產(chǎn)次數(shù)越多,腎臟的功能失調(diào)表現(xiàn)以及血瘀的病機變化越突出。3.反復(fù)體外受精-胚胎移植失敗患者曾患子宮腺肌病、子宮內(nèi)膜異位癥病史及免疫性疾病者表現(xiàn)為腎臟的功能失調(diào)以及血瘀的病機變化;曾患內(nèi)分泌疾病者表現(xiàn)為腎、肝、胞宮的功能失調(diào)以及血瘀、陰虛的病機變化;曾患宮腔病變者表現(xiàn)為腎、肝、胞宮的功能失調(diào);曾患炎癥性疾病者表現(xiàn)為腎的功能失調(diào)。結(jié)論:反復(fù)體外受精-胚胎移植失敗常見病位證素依次為:腎、胞宮、肝、脾、心。常見病性證素依次為:血瘀、陰虛、氣滯、濕、陽虛、痰、氣虛。證素特點與年齡、不孕病程、流產(chǎn)次數(shù)均具有相關(guān)性。反復(fù)體外受精-胚胎移植失敗患者曾患子宮腺肌病或子宮內(nèi)膜異位癥病史及免疫性疾病者表現(xiàn)為腎臟的功能失調(diào)以及血瘀的病機變化;曾患有內(nèi)分泌性疾病者表現(xiàn)為腎、肝、胞宮的功能失調(diào)以及血瘀、陰虛的病機變化;曾患有宮腔病變者表現(xiàn)為腎、肝、胞宮的功能失調(diào);曾患有炎癥性疾病者表現(xiàn)為腎的功能失調(diào)。
[Abstract]:Objective: to study the distribution of syndromes in patients with repeated in vitro fertilization and embryo transfer failure and their correlation with age, course of infertility, times of abortion and history of infertility. In order to better guide the disease in clinical prevention and treatment. Methods: the basic personal information of 92 patients with repeated failure of IVF-ET and the four diagnosis information of TCM syndromes were collected by the method of clinical epidemiological investigation. The collected information was analyzed by the integration of syndromes and statistical methods. The distribution characteristics of syndromes and their relationship with age, course of infertility, times of abortion and past history were clarified. The result is 1: 1. The most common syndromes of failure of repeated in vitro fertilization and embryo transfer were kidney, liver, uterus, spleen and heart, of which 88 cases were syndromes and kidney, accounting for 95.775% of the total, followed by cystonia and liver, respectively 80 cases (87.0%) and 85.9 cases (87.0%). The common syndromes were yin deficiency, blood stasis, qi stagnation, dampness, phlegm, yang deficiency and qi deficiency. There were 90 cases of syndromes and blood stasis, accounting for 97.8%, accounting for the largest proportion, Yin deficiency and Qi stagnation were followed by 85 cases (71 cases), accounting for 92.4% (77.2%). The characteristics of syndromes are correlated with age, course of infertility, number of miscarriages, as follows: the older the age, the more prominent the maladjustment of kidney function and the pathogenesis of yin deficiency; the longer the course of infertility, the longer the course of infertility. The more the number of miscarriages, the more prominent the dysfunction of kidney and the pathogenesis of blood stasis. Patients with repeated in vitro fertilization and embryo transfer failure had adenomyosis, history of endometriosis and immunological diseases as kidney dysfunction and blood stasis, and those with endocrine diseases presented with kidney and liver. The dysfunction of the uterus and the changes of the pathogenesis of blood stasis and yin deficiency; the dysfunction of the kidney, liver and uterus; the dysfunction of the kidney in the patients with inflammatory diseases. Conclusion: the most common syndromes of repeated in vitro fertilization and embryo transfer failure are kidney, uterus, liver, spleen and heart. Common disease syndrome factors in turn are: blood stasis, Yin deficiency, Qi stagnation, dampness, Yang deficiency, phlegm, Qi deficiency. The characteristics of syndromes were correlated with age, course of infertility and times of abortion. Patients with recurrent in vitro fertilization and failed embryo transfer had a history of adenomyosis or endometriosis and immunological disorders, characterized by dysfunction of the kidney and changes in the pathogenesis of blood stasis; people with endocrine diseases presented with kidney and liver. The dysfunction of the uterus and the changes of the pathogenesis of blood stasis and yin deficiency; the dysfunction of the kidney, liver and uterus in the patients with intrauterine diseases; the dysfunction of the kidney in the patients with inflammatory diseases.
【學(xué)位授予單位】:山東中醫(yī)藥大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2016
【分類號】:R271.9
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