本文選題：芪參通絡飲 + 穩(wěn)定型心絞痛��； 參考：《黑龍江中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:觀察芪參通絡飲治療冠心病穩(wěn)定型心絞痛(氣虛血瘀型)的運動耐量及對血清SOD和MDA水平的影響。方法:根據(jù)納入標準與排除標準,將符合納入標準的60例冠心病穩(wěn)定型心絞痛患者按照隨機數(shù)表法隨機分為治療組30例和對照組30例,治療組應用芪參通絡飲口服加萬爽力并配合常規(guī)治療,對照組予萬爽力口服同時配合常規(guī)治療,觀察周期為4周,即28天,主要觀察結(jié)果為,觀察治療前后心絞痛發(fā)作癥狀情況、中醫(yī)證候情況、中醫(yī)癥狀積分、硝酸甘油停減率,運動平板試驗總時間、代謝當量、血清SOD水平、血清MDA水平以及血、尿、便常規(guī)和肝腎功能等的變化。結(jié)果:1.經(jīng)治療,中醫(yī)癥狀積分治療組與對照組分別與治療前進行比較,治療組與對照組相較于治療前均明顯降低,差異具有統(tǒng)計學意義,具有及顯著性差異(P0.01),說明兩組治療對于中醫(yī)癥狀積分均有意義。治療組與對照組的治療情況進行比較時,治療組療后的的中醫(yī)癥狀積分明顯低于對照組療后的中醫(yī)癥狀積分,差異有統(tǒng)計學意義(P0.05),具有顯著性差異,說明治療組與對照組在治療前后均能使中醫(yī)癥狀積分明顯降低,并且治療組與對照組進行比較時,治療組的對于中醫(yī)癥狀積分的治療情況優(yōu)于對照組。2.經(jīng)治療,比較治療后情況,治療組患者對于心絞痛療效、硝酸甘油停減率與中醫(yī)證候療效這三個方面的的總有效率,治療組的治療情況較對照組來說均高于對照組,差異有統(tǒng)計學意義(P0.05),具有顯著性差異,說明治療組對于心絞痛、硝酸甘油停減率與中醫(yī)證候這三個方面的治療效果要優(yōu)于對照組。3.經(jīng)治療,比較治療后情況,治療組運動平板試驗的總時間和代謝當量這兩個方面較治療前相比較都有明顯增高,差異有統(tǒng)計學意義(P0.01),具有及其顯著性差異;對照組運動平板試驗的總時間治療前后比較有所增高,差異有統(tǒng)計學意義(P0.05),具有顯著性差異;對照組代謝當量治療前后比較明顯增高,差異有統(tǒng)計學意義(P0.05),具有顯著性差異;說明對照組運動平板試驗的總時間和代謝當量,治療后的治療組與對照組進行組間比較均有差異,有統(tǒng)計學意義(P0.05),具有顯著性差異。說明平板試驗的總時間和代謝當量,治療組優(yōu)于對照組(P0.05)。說明治療組與對照組的治療情況分別相較于治療前來說都有差異,且治療組的治療情況優(yōu)于對照組。4.經(jīng)治療,治療組和對照組患者血清中治療前后的SOD含量均有顯著升高,MDA均有顯著降低,差異有顯著性意義(P0.01),說明治療前后,治療組與對照組均能使血清中SOD含量顯著升高,MDA顯著降低,兩組治療前后比較,對于患者SOD水平和MDA水平的改善情況均有統(tǒng)計學差異。兩組間相比較,血清中SOD含量有所升高,MDA含量有所降低,差異有統(tǒng)計學意義(P0.05),具有顯著性差異。說明治療組和對照組血清中治療前后的SOD含量水平與MDA含量水平這兩方面與治療前相比均有明顯改變,而且相對于的SOD含量水平與MDA含量水平這兩方面且治療組的治療效果優(yōu)于對照組。結(jié)論:1.芪參通絡飲能夠改善冠心病穩(wěn)定型心絞痛(氣虛血瘀型)患者的心絞痛療效、中醫(yī)癥狀積分、中醫(yī)證候以及提高硝酸甘油停減率。2.芪參通絡飲能夠明顯提高冠心病穩(wěn)定型心絞痛(氣虛血瘀型)患者的運動耐量。3.芪參通絡飲能夠使冠心病穩(wěn)定型心絞痛(氣虛血瘀型)患者的SOD升高,MDA降低,發(fā)揮其抗氧化作用,從而起到治療CHD的作用。
[Abstract]:Objective: To observe the effect of Qisheng Tongluo Decoction on the exercise tolerance and the level of serum SOD and MDA in stable angina pectoris (Qi deficiency and blood stasis type). Methods: according to the standard and exclusion criteria, 60 patients with stable angina pectoris were randomly divided into 30 cases and 30 cases in the control group according to the random number table method. The treatment group was treated with Qisheng Tongluo Decoction plus Wan Shuang force combined with conventional treatment. The control group was given Wan Shuang force oral and routine treatment. The observation period was 4 weeks, that is, 28 days, the main observation results were, the symptoms of angina pectoris, TCM syndromes, the symptom score of Chinese medicine, the rate of nitroglycerin withdrawal, and exercise plate test were observed before and after treatment. Total time, metabolic equivalent, serum SOD level, serum MDA level, blood, urine, urine, routine and liver and kidney function and other changes. Results: 1. the treatment group and the control group compared with the control group before treatment, the treatment group and the control group were significantly lower than the control group before treatment, the difference was statistically significant, and the difference was significant difference. Difference (P0.01), indicating that two groups of treatment for the TCM symptom score has significance. The treatment group compared with the control group, the treatment group after the treatment of the TCM symptom score was significantly lower than the control group after the treatment of traditional Chinese medicine symptom score, the difference was statistically significant (P0.05), with significant differences, indicating the treatment group and the control group before treatment. After the treatment group was compared with the control group, the treatment group was better than the control group when compared with the control group. The treatment group was better than the control group.2., compared with the treatment group, the treatment group was more effective in the three aspects of the curative effect of angina pectoris, the reduction rate of nitroglycerin and the curative effect of TCM syndrome. Compared with the control group, the treatment group was higher than the control group. The difference was statistically significant (P0.05), with significant difference. The treatment group was better than the control group.3. treatment for angina, nitroglycerin reduction and TCM syndrome, compared with the control group, after the treatment, the treatment group exercise tablet test in general. The two aspects of time and metabolic equivalent were significantly higher than those before treatment. The difference was statistically significant (P0.01) and had significant differences. The control group had a significant difference before and after the total time treatment of exercise plate test, the difference was statistically significant (P0.05), and the control group was compared before and after the metabolic equivalent treatment. The difference was statistically significant (P0.05), with significant difference. It showed that the total time and metabolic equivalent of the exercise plate test in the control group were different between the treatment group and the control group, with significant difference (P0.05). It showed that the total time and metabolic equivalent of the tablet test were superior to those in the treatment group. In the control group (P0.05), the treatment group was compared with the control group before the treatment, and the treatment group was better than the control group.4.. The SOD content in the treatment group and the control group before and after the treatment in the serum were significantly increased, and the MDA had a significant decrease, the difference was significant (P0.01). Before and after treatment, both the treatment group and the control group could significantly increase the content of SOD in the serum, and significantly decrease the MDA. The two groups were compared before and after treatment, and there were significant differences in the improvement of the level of SOD and MDA in the patients. Compared with the two groups, the content of SOD in the serum was increased and the content of MDA decreased, and the difference was statistically significant (P0.05). The difference was significant (P0.05). The two aspects of the level of SOD and the level of MDA before and after treatment in the treatment group and the control group were significantly different from those before the treatment, and compared with the two aspects of the level of SOD and the level of MDA, and the therapeutic effect of the treatment group was better than that of the control group. Conclusion: 1. Qi Shen Tongluo Decoction can improve the coronary heart disease. The effect of angina pectoris in patients with stable angina pectoris (Qi deficiency and blood stasis), TCM symptom score, TCM syndrome and improvement of the rate of stopping and subtraction of nitroglycerin.2. Qisheng Tongluo Decoction can obviously improve the exercise tolerance of.3. Qi Shen Tongluo Decoction (Qi Shen Tongluo Decoction) in patients with stable angina pectoris (Qi deficiency and blood stasis type), which can make the stable angina pectoris (Qi deficiency and blood stasis type) of coronary heart disease (Qi deficiency and blood stasis type) SOD increased and MDA decreased, exerting its antioxidant effect, thereby playing a role in the treatment of CHD.

【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R259

【參考文獻】

相關(guān)期刊論文 前10條

1 羅剛;葉穗林;;黃連溫膽湯加味治療冠心病穩(wěn)定型心絞痛患者療效觀察[J];中國中醫(yī)急癥;2017年03期

2 劉曉丹;潘濤;;紅景天苷對心肌缺血-再灌注大鼠心肌梗死面積及細胞凋亡的影響[J];中西醫(yī)結(jié)合心腦血管病雜志;2016年23期

3 敖勇;羅楊;楊建;趙艷華;;丹參注射液對冠心病患者血清LPO、SOD、NO及MDA的影響[J];中國生化藥物雜志;2016年01期

4 黃修解;黃金龍;蒙定水;;蒙定水教授治療冠心病經(jīng)驗總結(jié)[J];廣西中醫(yī)藥;2015年06期

5 王宇;徐穎穎;張相彩;鄭韌;朱圣婷;王懷沖;;鈣離子拮抗劑類降壓藥的臨床應用及不良反應[J];中國現(xiàn)代應用藥學;2015年03期

6 王梓良;鐘一鳴;王小萍;黃琴;;運動平板試驗對冠心病診斷價值的臨床分析[J];贛南醫(yī)學院學報;2014年04期

7 臧文華;李冰冰;唐德才;殷沈華;;補氣活血藥對急性心肌梗死模型大鼠梗死心肌邊緣區(qū)域SDF-1、CXCR4蛋白及mRNA表達的影響[J];世界科學技術(shù)-中醫(yī)藥現(xiàn)代化;2014年06期

8 張如意;王嬌;陳容平;楊銳;孫嘉;宋青青;蔡德鴻;;尿微量白蛋白陰性的超重肥胖2型糖尿病患者估算的腎小球濾過率下降的相關(guān)危險因素分析[J];中華內(nèi)分泌代謝雜志;2014年01期

9 包曉青;孫天福;袁智宇;;袁氏鎮(zhèn)心痛口服液治療冠心病穩(wěn)定型心絞痛50例[J];中醫(yī)研究;2013年11期

10 方瑜;孫瑤;簡潔;;九龍?zhí)倏傸S酮對垂體后葉素致大鼠急性心肌缺血的保護作用[J];中國藥理學通報;2013年11期

，

本文編號：1837531