本文選題：面癱 + 功能磁共振�。� 參考：《中國(guó)科學(xué)技術(shù)大學(xué)》2016年碩士論文

【摘要】：貝爾氏面癱是常見的由面部神經(jīng)受損引發(fā)的疾病,多表現(xiàn)為特發(fā)的、單一的面部麻痹。其主要發(fā)病原因是面神經(jīng)水腫而引發(fā)支配面部運(yùn)動(dòng)的神經(jīng)回路受損,但其面神經(jīng)水腫的最初原因還未得證實(shí)。針灸是中國(guó)傳統(tǒng)的醫(yī)療手段之一,在亞洲,針灸常被用于治療面癱。雖然針灸治療的機(jī)制尚不清晰,但其臨床療效卻有目共睹。在針灸治療面癱中,面癱側(cè)對(duì)側(cè)的合谷穴是首要針刺穴位,但有時(shí)也會(huì)選擇同側(cè)的合谷穴作為治療穴位。但是,同側(cè)針刺與對(duì)側(cè)針刺促使面癱的康復(fù)機(jī)制是否相同卻未曾證實(shí)。本研究基于此,借助功能磁共振的手段,通過(guò)研究針灸誘導(dǎo)的初級(jí)軀體感覺(jué)皮層(SI)的功能連接變化,來(lái)探究同側(cè)針刺和對(duì)側(cè)針刺的作用機(jī)制是否存在差異。本文具體研究?jī)?nèi)容是探究同側(cè)針刺與對(duì)側(cè)針刺誘導(dǎo)的SI功能連接改變情況。本研究分為兩組實(shí)驗(yàn)組及一組健康對(duì)照組,實(shí)驗(yàn)采集了所有被試靜息態(tài)功能磁共振數(shù)據(jù)及健康人任務(wù)態(tài)功能磁共振數(shù)據(jù)。本研究首先通過(guò)計(jì)算健康人任務(wù)態(tài)數(shù)據(jù)獲取種子點(diǎn)即雙側(cè)Si的具體位置。再對(duì)各組針刺前針刺后的數(shù)據(jù)計(jì)算了雙側(cè)Si功能連接的狀況。實(shí)驗(yàn)比較了各組內(nèi)針刺前與針刺后雙側(cè)SI功能連接的情況,其顯示同側(cè)針刺與健康人針刺前后雙側(cè)SI功能連接沒(méi)有明顯改變,而對(duì)側(cè)針刺組出現(xiàn)了明顯改變�；诖私Y(jié)果,本文對(duì)對(duì)側(cè)針刺誘導(dǎo)的SI功能連接改變區(qū)域進(jìn)行了深入探討。在此基礎(chǔ)上,本研究進(jìn)·步采取了差檢驗(yàn)的方法,比較了同側(cè)針刺與對(duì)側(cè)針刺誘導(dǎo)雙側(cè)Si功能連接改變的差異性。其結(jié)果顯示,同側(cè)針刺與對(duì)側(cè)針刺前后SI功能連接的改變存在差異性。基于此,本文還推測(cè)了針刺治療面癱的可能機(jī)制。
[Abstract]:Bell's facial palsy is a common disease caused by facial nerve damage, characterized by idiopathic, single facial paralysis. The main cause of facial nerve edema is the damage of the nerve circuit which innervates facial movement, but the initial cause of facial nerve edema has not been proved. Acupuncture is one of the traditional medical methods in China. In Asia, acupuncture is often used to treat facial paralysis. Although the mechanism of acupuncture and moxibustion therapy is not clear, its clinical effect is obvious to all. In acupuncture and moxibustion treatment of facial paralysis, Hegu point on the opposite side of facial paralysis is the primary acupuncture point, but sometimes it also chooses the same side Hegu point as the treatment point. However, the recovery mechanism of ipsilateral acupuncture and contralateral acupuncture for facial paralysis has not been proved. Based on this, the functional connection of primary somatosensory cortex (SI) induced by acupuncture and moxibustion was studied by means of functional magnetic resonance (fMRI) to explore whether there are differences in the mechanism of ipsilateral acupuncture and contralateral acupuncture. The purpose of this study is to explore the changes of SI functional junctions induced by ipsilateral acupuncture and contralateral acupuncture. This study was divided into two groups: two experimental groups and one healthy control group. The rest functional magnetic resonance (fMRI) data and the task-state functional magnetic resonance (fMRI) data of all subjects were collected. In this study, the specific position of the seed point, namely bilateral Si, was obtained by calculating the task state data of healthy people. The data of each group before and after acupuncture were used to calculate the status of bilateral Si functional connections. The bilateral SI functional connections before and after acupuncture in each group were compared. The results showed that there were no significant changes in the bilateral SI functional junctions between the ipsilateral acupuncture group and the healthy subjects before and after acupuncture, but the contralateral acupuncture group showed obvious changes. Based on these results, the changes of SI functional junctions induced by lateral acupuncture are discussed in detail. On this basis, the difference between ipsilateral acupuncture and contralateral acupuncture induced changes of bilateral Si functional junctions was compared. The results showed that the changes of SI functional junctions before and after ipsilateral acupuncture and contralateral acupuncture were different. Based on this, we also speculate the possible mechanism of acupuncture treatment of facial paralysis.
【學(xué)位授予單位】：中國(guó)科學(xué)技術(shù)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R246.6;R445.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 劉軍平;徐春生;盧琦;李傳富;楊駿;;基于局部一致性算法的周圍性面癱針刺治療靜息態(tài)功能MRI研究[J];磁共振成像;2014年06期

2 沈小雨;楊佳敏;張玲;申松希;齊丹丹;張露芬;朱江;;針刺得氣的客觀化研究進(jìn)展[J];中華中醫(yī)藥雜志;2014年10期

3 楊軍;肖海燕;何賢國(guó);曾憲華;;磁共振成像儀原理及故障排除探討[J];中國(guó)醫(yī)學(xué)裝備;2011年11期

，

本文編號(hào)：1837069