本文選題：小兒安神補(bǔ)腦顆粒 + 抽動(dòng)障礙��； 參考：《時(shí)珍國(guó)醫(yī)國(guó)藥》2017年08期

【摘要】：目的探討小兒安神補(bǔ)腦顆粒治療抽動(dòng)障礙(TD)脾虛肝亢證患兒的臨床療效,并探討其作用機(jī)制。方法將120例脾虛肝亢證TD患兒,采用隨機(jī)數(shù)字表法分為治療組和對(duì)照組各60例,治療組給予小兒安神補(bǔ)腦顆粒,對(duì)照組給予氟哌啶醇治療,治療前后對(duì)病情嚴(yán)重程度進(jìn)行耶魯抽動(dòng)癥整體嚴(yán)重程度量表(YGTSS)評(píng)分和中醫(yī)證候評(píng)分,采用酶聯(lián)免疫吸附實(shí)驗(yàn)檢測(cè)外周血腫瘤壞死因子-α(TNF-α)、白介素(IL)-12p70水平,治療3個(gè)月后評(píng)價(jià)疾病療效、證候療效及安全性。結(jié)果治療組與對(duì)照組的臨床總有效率及YGTSS評(píng)分差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療組中醫(yī)證候療效為90.0%(54/60),高于對(duì)照組[73.3%(44/60)],兩組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療組可降低TD患兒中醫(yī)證候評(píng)分,降低外周血TNF-α及IL-12p70水平,與對(duì)照組比較有顯著性差異(P0.05)。結(jié)論小兒安神補(bǔ)腦顆粒治療兒童TD脾虛肝亢證效果明顯,降低外周血TNF-α及IL-12p70水平,這可能是其治療TD的作用機(jī)制之一。
[Abstract]:Objective to investigate the clinical effect of Anshenbunao granule in treating the syndrome of spleen deficiency and liver hyperactivity in children with twitch disorder (TD), and to explore its mechanism. Methods 120 children with spleen deficiency and liver hyperactivity syndrome were randomly divided into treatment group (n = 60) and control group (n = 60). Before and after treatment, the YGTSS and TCM syndromes were used to evaluate the severity of the disease, and the levels of TNF- 偽 and IL-12p70 in peripheral blood were detected by enzyme-linked immunosorbent assay (Elisa), and the levels of TNF- 偽 and IL-12p70 in peripheral blood were measured by enzyme-linked immunosorbent assay (Elisa). After 3 months of treatment, the efficacy, syndromes and safety of the disease were evaluated. Results there was no significant difference in the total effective rate and YGTSS score between the treatment group and the control group (P 0.05), and the curative effect of TCM syndrome in the treatment group was 90.054 / 60, which was higher than that in the control group [73.3% 44 / 60]. The levels of TNF- 偽 and IL-12p70 in peripheral blood were significantly lower than those in control group (P 0.05). Conclusion Anshenbunao granule is effective in treating children with TD spleen deficiency and liver hyperactivity, and decreases the levels of TNF- 偽 and IL-12p70 in peripheral blood, which may be one of the mechanisms of its treatment of TD.
【作者單位】： 海口市中醫(yī)醫(yī)院;海南醫(yī)學(xué)院中醫(yī)學(xué)院;廣東省深圳市中醫(yī)院;
【基金】：國(guó)家人社部留學(xué)回國(guó)人員擇優(yōu)項(xiàng)目(No.2014A020221003) 廣東省中醫(yī)藥局建設(shè)中醫(yī)藥強(qiáng)省立項(xiàng)資助項(xiàng)目(No.20151079)
【分類號(hào)】：R277.7

【相似文獻(xiàn)】

相關(guān)期刊論文 前3條

1 孔慶芳;淺談“若要小兒安,常帶三分饑與寒”[J];江西中醫(yī)學(xué)院學(xué)報(bào);1999年04期

2 黎漢津;;欲得小兒安,留得三分饑與寒[J];醫(yī)學(xué)文選;1991年06期

3 李茵;劉艷驕;;中醫(yī)對(duì)嬰幼兒睡眠的調(diào)護(hù)[J];中國(guó)中醫(yī)藥現(xiàn)代遠(yuǎn)程教育;2012年16期

相關(guān)會(huì)議論文 前1條

1 馮曉純;王艷玲;馮曉娜;;“若要小兒安,常受三分饑與寒”[A];2009年全國(guó)中醫(yī)藥科普高層論壇論文集[C];2009年

相關(guān)重要報(bào)紙文章 前2條

1 韓詠霞;嬰兒慎服小兒安[N];中國(guó)醫(yī)藥報(bào);2006年

2 長(zhǎng)春中醫(yī)藥大學(xué)附屬醫(yī)院 馮曉純 王艷玲 馮曉娜;若要小兒安 常受三分饑與寒[N];健康報(bào);2009年

，

本文編號(hào)：1819763