本文選題：肝郁血虛夾瘀型 + 偏頭痛　； 參考：《河南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:研究疏肝補(bǔ)血祛瘀沖劑在臨床上治療肝郁血虛夾瘀型偏頭痛的效果,記錄受試者治療前后西醫(yī)臨床癥狀變化、中醫(yī)證候改善情況、血小板聚集率、安全性指標(biāo)、遠(yuǎn)期治療效果等,對(duì)此藥的治療和預(yù)防效果進(jìn)行評(píng)價(jià),同時(shí)探索其機(jī)制,進(jìn)而更好的發(fā)揮中醫(yī)藥的優(yōu)勢(shì),為偏頭痛的治療開(kāi)闊新的方法與思路。方法:所選偏頭痛(肝郁血虛夾瘀型)受試對(duì)象均于2015年4月至2015年12月之間診治于河南中醫(yī)藥大學(xué)二附院神經(jīng)內(nèi)科門(mén)診。采用隨機(jī)對(duì)照的原則分為A、B兩組,二者均為36例。再采用奇偶法,隨機(jī)把A組設(shè)置為治療組,B組設(shè)置為對(duì)照組,二者均為36例。對(duì)照組給以西比靈,治療組給以疏肝補(bǔ)血祛瘀沖劑和西比靈,兩組均治療30天,觀察患者的臨床癥狀改善情況、中醫(yī)證候變化、血小板聚集率、安全性指標(biāo)等,對(duì)比兩組治療的臨床效果。試驗(yàn)完成后60天回訪患者,分析其復(fù)發(fā)的情況以研究此藥的預(yù)防效果。結(jié)果:1.西醫(yī)臨床療效改善情況:中藥沖劑加西比靈組臨床癥狀改善率90.00%,西比靈組臨床癥狀改善率73.33%,p0.05,對(duì)比有統(tǒng)計(jì)學(xué)意義。2.中醫(yī)證候改善情況:中藥加西比靈組改善率90.00%,西比靈組改善率76.67%,中藥加西比靈組中醫(yī)證候改善情況優(yōu)于西比靈組,p0.05,差異有統(tǒng)計(jì)學(xué)意義。3.疏肝補(bǔ)血祛瘀方藥具有明顯抗血小板聚集的功能。4.試驗(yàn)完成60天回訪,中藥加西比靈組復(fù)發(fā)率7.41%,西比靈組復(fù)發(fā)率32.14%,說(shuō)明疏肝補(bǔ)血祛瘀沖劑可以有效的預(yù)防頭風(fēng)病的復(fù)發(fā)。5.實(shí)驗(yàn)室等檢查項(xiàng)目皆在正常范圍內(nèi),并且未出現(xiàn)不良事件,不良反應(yīng)經(jīng)統(tǒng)計(jì)學(xué)分析無(wú)意義,說(shuō)明試驗(yàn)藥物皆安全。結(jié)論:疏肝補(bǔ)血祛瘀沖劑對(duì)肝郁血虛夾瘀型偏頭痛不僅有明顯的治療效果而且具有較好的預(yù)防效果。此方和西比靈聯(lián)合應(yīng)用治療和預(yù)防偏頭痛,在改善臨床癥狀、中醫(yī)證候、血小板聚集率等方面,有明顯的優(yōu)勢(shì),并且安全可靠,值得進(jìn)一步研究、開(kāi)發(fā)、推廣。
[Abstract]:Objective: to study the clinical effect of Shugan Buxue Quyu granule on treating migraine with stagnation of liver and blood deficiency, and to record the changes of clinical symptoms, improvement of TCM syndrome, platelet aggregation rate and safety index before and after treatment. The long term therapeutic effect and so on, the treatment and prevention effect of this medicine are evaluated, and its mechanism is explored at the same time, so that the advantages of traditional Chinese medicine can be better brought into play, and new methods and ideas for the treatment of migraine can be opened up. Methods: the subjects of migraine (liver depression and blood deficiency with blood stasis) were treated and treated in Department of Neurology, second affiliated Hospital of Henan University of traditional Chinese Medicine between April 2015 and December 2015. According to the principle of random control, 36 cases were divided into two groups: group A (n = 36) and group B (n = 36). Using parity method, group A was randomly divided into treatment group and B group as control group, both of which were 36 cases. The control group was given sibelium, the treatment group was given Shugan Bu Xue Quyu granule and the other two groups were treated for 30 days. The improvement of clinical symptoms, changes of TCM syndrome, platelet aggregation rate, safety index and so on were observed. The clinical effects of the two groups were compared. Patients were interviewed 60 days after the trial and their recurrence was analyzed to study the preventive effect of the drug. The result is 1: 1. The improvement of clinical effect of western medicine: the improvement rate of clinical symptoms in the traditional Chinese medicine granule plus sibelium group was 90.00. the clinical symptom improvement rate in the sibiline group was 73.33p 0.05, the comparison was statistically significant. The improvement of TCM syndromes: the improvement rate of traditional Chinese medicine plus sibelium group was 90.00g, the improvement rate of sibelium group was 76.67m, and the improvement of TCM syndrome of Chinese medicine plus sibelium group was better than that of sibiline group (P 0.05), the difference was statistically significant. The prescription of soothing liver, tonifying blood and removing blood stasis has obvious function of anti-platelet aggregation. 4. After 60 days' visit, the recurrence rate of Chinese medicine plus sibiline group was 7.41 and that of sibiline group was 32.14, which indicated that Shugan Buxue Quyu granule could effectively prevent the recurrence of head wind disease. Laboratory tests were all within normal range, and no adverse events occurred. The adverse reactions were meaningless by statistical analysis, indicating that all the test drugs were safe. Conclusion: Shugan Buxue Quyu granule not only has obvious therapeutic effect but also has better preventive effect on migraine caused by liver stagnation and blood deficiency. The combination treatment and prevention of migraine with sibelium has obvious advantages in improving clinical symptoms, TCM syndromes, platelet aggregation rate, and is safe and reliable. It is worthy of further study, development and promotion.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R277.7

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