本文選題：心腎不交 + 不寐��； 參考：《長春中醫(yī)藥大學》2016年碩士論文

【摘要】：目的:觀察清心安神顆粒治療原發(fā)性失眠(心腎不交型)臨床療效。方法:研究選取于長春中醫(yī)藥大學附屬醫(yī)院腦病門診及療區(qū)就診的心腎不交型不寐證患者72例,隨機分為治療組38例、對照組34例,實驗觀察過程中治療組脫落8例,對照組脫落4例。治療組予以清心安神顆粒治療,對照組給予百樂眠膠囊口服治療,進行為期8周的臨床療效觀察。觀察治療前后兩組患者的匹茲堡睡眠質(zhì)量指數(shù)、中醫(yī)癥候積分、中醫(yī)癥狀評分及中醫(yī)臨床療效評分、多導睡眠圖(部分)。結(jié)果:經(jīng)臨床療效觀察,治療組能夠有效降低匹茲堡睡眠指數(shù)、中醫(yī)證候積分,治療組治療效果優(yōu)于對照組(P0.05),中醫(yī)臨床癥狀改善方面治療組優(yōu)于對照組,治療組總有效率為90.00%,對照組總有效率為63.33%,治療組與對照組比較具有極顯著的差異(P0.01)。通過多導睡眠圖觀察治療效果顯示,清心安神顆粒能明顯改善睡眠結(jié)構(gòu)、延長深睡眠時間,差異具有顯著性(P0.05)。結(jié)論:清心安神顆粒治療心腎不交型不寐證療效顯著,尤其對深睡眠期結(jié)構(gòu)的改善優(yōu)勢明顯,從根本上解決患者的失眠困擾,臨床上值得推廣。
[Abstract]:Objective: to observe the clinical effect of Qingxin Anshen granule on primary insomnia. Methods: a total of 72 patients with heart and kidney disjoint insomnia were randomly divided into treatment group (n = 38), control group (n = 34) and treatment group (n = 8). In the control group, 4 cases were lost. The treatment group was treated with Qingxin Anshen granule and the control group was treated with Baile Mian capsule orally for 8 weeks. The Pittsburgh Sleep quality Index (PQI), TCM symptom score, TCM symptom score, TCM Clinical efficacy score and polysomnography were observed before and after treatment. Results: after clinical observation, the treatment group can effectively reduce Pittsburgh sleep index, TCM syndrome score, the treatment group is better than the control group P0.05, the treatment group is better than the control group in improving clinical symptoms. The total effective rate of the treatment group was 90.00g and the total effective rate of the control group was 63.33. There was a significant difference between the treatment group and the control group (P 0.01). The results of polysomnography showed that Qingxin Anshen granule could obviously improve the sleep structure and prolong the time of deep sleep, and the difference was significant (P 0.05). Conclusion: Qingxin Anshen granule has obvious curative effect on the syndrome of heart and kidney disjoint insomnia, especially on the improvement of the structure of deep sleep. It is worth popularizing in clinic.
【學位授予單位】：長春中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R256.23

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