本文選題：中藥超微顆粒化瘀止痛方 + 癌性疼痛�。� 參考：《湖南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察中藥超微顆�；鲋雇捶酵夥笾委煾共恐卸劝┬蕴弁吹寞熜б约捌鋵颊逳RS評分、KPS評分的影響、藥物的不良反應(yīng)及安全性,探索中藥超微顆粒的新用法,為中藥超微顆�；鲋雇捶街委煱┬蕴弁吹呐R床應(yīng)用提供理論依據(jù)。方法:將患者分為觀察組與對照組,各30例,觀察組給予中藥超微顆�；鲋雇捶酵夥�,對照組予以奇正消痛貼外用,療程均為1周。治療結(jié)束后,比較兩組患者的NRS評分、疼痛緩解率、止痛起效時間、最佳止痛時間、鎮(zhèn)痛持續(xù)時間、KPS評分,觀察藥物的安全性及不良反應(yīng)。結(jié)果:1.NRS評分:治療后兩組NRS評分均較治療前明顯降低,具有較好的止痛效果,在降低NRS評分方面兩組療效相當(dāng)。2.止痛有效率:觀察組總有效率86.7%;對照組總有效率83.4%。經(jīng)檢驗,P0.05,兩組止痛有效率相當(dāng)。3.止痛起效時間、最佳止痛時間、鎮(zhèn)痛持續(xù)時間:觀察組與對照組止痛起效時間相當(dāng),觀察組的最佳止痛時間、鎮(zhèn)痛持續(xù)時間均長于對照組。4.KPS評分:治療后兩組KPS評分均較治療前明顯升高,兩組治療均能提高患者的KPS評分。兩組在提高KPS評分方面水平相當(dāng)。5.不良反應(yīng):治療后觀察組兩組患者皮膚瘙癢、皮疹、敷藥脫落發(fā)生率,經(jīng)統(tǒng)計學(xué)分析,P0.05,差異無統(tǒng)計學(xué)意義。6.安全性觀察:治療后檢查心電圖、大小便常規(guī),抽血查血常規(guī)、肝腎功能、凝血功能等結(jié)果均未發(fā)現(xiàn)明顯異常。結(jié)論:1.中藥超微顆�；鲋雇捶侥芙档突颊逳RS評分,對腹部中度癌性疼痛有較好的療效,止痛有效率與奇正消痛貼相當(dāng);2.中藥超微顆粒化瘀止痛方止痛起效時間與奇正消痛貼相當(dāng);最佳止痛時間、鎮(zhèn)痛持續(xù)時間均長于奇正消痛貼。3.中藥超微顆�；鲋雇捶皆谟行е委煱┩吹耐瑫r,可提高患者生活質(zhì)量,且無明顯不良反應(yīng),安全、無毒副作用。對于腹部中度癌痛的病人值得推廣。
[Abstract]:Objective: to observe the curative effect of traditional Chinese medicine ultrafine granule Huayu Zhitong prescription on abdominal moderate cancer pain and its effect on NRS score of patients, adverse drug reaction and safety, and to explore the new use of ultrafine granules of traditional Chinese medicine. To provide theoretical basis for the clinical application of traditional Chinese medicine ultrafine granule Huayu Zhitong prescription in the treatment of cancer pain. Methods: the patients were divided into the observation group (n = 30) and the control group (n = 30). The observation group was treated with traditional Chinese medicine ultrafine granule Huayu Zhitong prescription and the control group was treated with Qizhengxiaotong paste for one week. After the treatment, the NRS score, pain relief rate, analgesic onset time, optimal analgesic time and analgesic duration were compared between the two groups, and the safety and adverse reactions of the drugs were observed. Results 1.NRS score: after treatment, the NRS scores of the two groups were significantly lower than those before treatment, and had a better analgesic effect. The two groups had the same curative effect in reducing the NRS score. 2. The total effective rate of pain relief was 86.7 in the observation group and 83.4 in the control group. The effective rate of pain relief in the two groups was equivalent to 3. 3. The time of analgesic effect, the best time of analgesic effect, the duration of analgesia: the time of analgesic effect in the observation group was the same as that in the control group, and the best time of pain relief in the observation group, The duration of analgesia was longer than that of the control group. 4. KPS scores: after treatment, the KPS scores of the two groups were significantly higher than those before treatment, and both groups could improve the KPS score of the patients. The two groups were equal in improving KPS scores. 5. 5. Adverse reactions: after treatment, the incidence of pruritus, rashes, and shedding of drugs in the observation group was not statistically significant (P 0.05), and there was no significant difference between the two groups. Safety observation: the results of electrocardiogram examination, routine examination of urine and urine, blood routine examination, liver and kidney function, coagulation function, etc. Conclusion 1. The traditional Chinese medicine ultrafine granule Huayu Zhitong prescription can reduce the patient's NRS score, has the better curative effect to the abdominal moderate cancerous pain, the analgesic effective rate is equivalent to the Qizhengxiaotong paste 2. The time of analgesic effect of traditional Chinese medicine ultrafine granule Huayu Zhitong recipe is the same as that of Qizheng Xiaotong paste, and the best analgesic time and analgesic duration are longer than that of Qizheng Xiaotong paste. 3. The traditional Chinese medicine ultrafine granule Huayu Zhitong prescription can effectively treat cancer pain, at the same time, can improve the quality of life of patients, and no obvious adverse reactions, safety, no toxic side effects. For patients with moderate abdominal cancer pain, it is worth promoting.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R273

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