本文選題：白癜風 + 桃紅白癜方��； 參考：《湖北中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:觀察桃紅白癜方治療氣滯血瘀型白癜風的臨床療效及安全性,充分發(fā)揮中醫(yī)中藥治療白癜風的特色優(yōu)勢,為臨床提供更加安全有效的治療途徑。方法:本次入選患者均來自于2015年5月-2016年5月湖北省中醫(yī)院皮膚科門診,在所有與白癜風診斷和排除標準相符的患者中選擇氣滯血瘀型作為本次研究對象,共觀察120個病例,采用隨機對照原則分為三組:治療組、對照組A、對照組B,每組40例。治療組采用內(nèi)服中藥桃紅白癜方水煎劑每日一劑,2次/日,200ml/次,基本藥物組成為:赤芍15g,丹皮20g,桃仁10g,紅花15g,柴胡10g,白芷15g,蟬蛻10g,蒲黃15g,補骨脂10g,丹參20g,當歸15g,紫河車5g,五靈脂15g,浮萍10g,雞血藤30g,同時聯(lián)合外擦鹵米松乳膏,2次/日,連用2周后停用一周,皮損處紫外線照射隔日1次。對照組A采用胸腺肽腸溶片口服,3次/日,2粒/次,同時聯(lián)合外擦鹵米松乳膏和皮損處紫外線照射(方法同前)。對照組B采用薄芝片口服,3次/日,2粒/次,鹵米松乳膏外擦和皮損處紫外線照射治療(方法同前)。4周為一療程,共觀察4個療程,根據(jù)治療前后皮損變化及復查血、尿、大便常規(guī)、肝腎功能情況,如實評價桃紅白癜方的臨床療效和安全性。結果:1.試驗共收集120例患者,完成111例,終止9例。2.治療1個療程后,治療組與對照組A、B對比療效均有統(tǒng)計學差異,P0.05。對照組A與B對比療效無統(tǒng)計學差異,P0.05;三組總有效率分別為51.4%、30.6%、26.3%。3.治療2個療程后,治療組與對照組A、B對比療效均有統(tǒng)計學差異,P0.05。對照組A與B對比療效有統(tǒng)計學差異,P0.05;三組總有效率分別為70.3%、50.0%、28.9%。4.治療3個療程后,治療組、對照組A對比對照組B療效均有統(tǒng)計學差異,P0.05。治療組與對照組A對比療效無統(tǒng)計學差異,P0.05;三組總有效率分別為73.0%、61.1%、42.1%。5.治療4個療程后,治療組、對照組A對比對照組B療效均有統(tǒng)計學差異,P0.05。治療組與對照組A對比療效無統(tǒng)計學差異,P0.05;三組總有效率分別為78.4%、69.4%、47.4%。結論:1.內(nèi)服桃紅白癜方聯(lián)合鹵米松乳膏和紫外線照射、口服胸腺肽腸溶片聯(lián)合鹵米松乳膏和紫外線照射及口服薄芝片聯(lián)合鹵米松乳膏和紫外線照射對氣滯血瘀型白癜風均有療效;2.內(nèi)服桃紅白癜方聯(lián)合鹵米松乳膏和紫外線照射相比于口服胸腺肽腸溶片聯(lián)合鹵米松乳膏和紫外線照射,在治療初期能較快控制病情,避免病情進一步發(fā)展。3.內(nèi)服桃紅白癜方聯(lián)合鹵米松乳膏和紫外線照射治療氣滯血瘀型白癜風,無論在近期還是遠期療效上,均優(yōu)于口服薄芝片聯(lián)合鹵米松乳膏和紫外線照射。4.內(nèi)服桃紅白癜方對氣滯血瘀型白癜風治療有效,能夠早期改善并穩(wěn)定患者病情,且患者血、尿、大便常規(guī)、肝腎功能指標均在正常范圍,臨床安全性好,值得進一步推廣使用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Taohong white purpura in the treatment of vitiligo with qi stagnation and blood stasis, to give full play to the unique advantages of traditional Chinese medicine in the treatment of vitiligo, and to provide a more safe and effective way for clinical treatment. Methods: all the patients were selected from the dermatology clinic of Hubei traditional Chinese Medicine Hospital from May 2015 to May 2016. The patients with Qi stagnation and Blood stasis were selected from all patients who were in accordance with the criteria of diagnosis and exclusion of vitiligo, and 120 cases were observed. Three groups were randomly divided into three groups: treatment group, control group A and control group B, with 40 cases in each group. The treatment group was treated with Chinese medicine Taohong white purpura decoction once a day twice a day and 200 ml / time. The essential drugs are: Radix Paeoniae Alba 15g, paeonia 20g, peach kernel 10g, safflower 15g, Bupleurum 10g, dahurica 15g, cicada slough 10g, fuhuang 15g, psoralen 10g, salvia miltiorrhiza 20g, angelica sinensis 15g, Ziheche 5g, Wulingfat 15g, duckweed 10g, chicken blood rattan 30g, at the same time combined with external brine and rice pine cream twice a day, After 2 weeks of continuous use, the skin was stopped for one week, and the lesions were irradiated by ultraviolet rays once every other day. Control group A was treated with Thymosin enteric-coated tablets 3 times a day and 2 tablets per day combined with external brine mizone cream and ultraviolet radiation at skin lesions. The control group B was treated by oral administration of Boshiba tablets three times a day, two tablets per day, and brine mizone cream and ultraviolet radiation at the lesion. (methods: the same course was given at 4 weeks before and after treatment, and 4 courses of treatment were observed. According to the changes of skin lesions before and after treatment and the reexamination of blood and urine, there was no significant difference between the two groups. Routine defecation, liver and kidney function, truthfully evaluate the clinical efficacy and safety of peach-red purpura. The result is 1: 1. A total of 120 patients were collected, 111 completed and 9 terminated. 2. 2. After one course of treatment, there was significant difference in the therapeutic effect between the treatment group and the control group (P 0.05). There was no significant difference in the curative effect between control group A and group B (P 0.05), and the total effective rate of three groups was 51.4 and 30.6 and 26.3respectively. After two courses of treatment, there was a significant difference in the therapeutic effect between the treatment group and the control group (P 0.05). The control group A and B contrast curative effect has the statistical difference (P0.05), the three groups total effective rate is respectively 70.3% 50.050.050.028. 9. 4. After 3 courses of treatment, the curative effect of treatment group and control group A was significantly different from that of control group B (P 0.05). There was no statistical difference between the treatment group and the control group (P 0.05), the total effective rates of the three groups were 73.0 and 61.1 respectively. After 4 courses of treatment, the curative effect of treatment group and control group A was significantly different from that of control group B (P 0.05). There was no significant difference in the curative effect between the treatment group and the control group (P 0.05). The total effective rate of the three groups was 78.4% and 69.4% respectively. Conclusion 1. Oral administration of Taohong white purpura prescription combined with halomethasone cream and ultraviolet radiation, oral thymosin enteric-coated tablets combined with halomethasone cream and ultraviolet radiation and oral Boshiba tablets combined with halogen milisone cream and ultraviolet radiation had curative effects on vitiligo of Qi stagnation and Blood stasis type. Compared with oral thymosin enteric-coated tablets combined with halomethasone cream and ultraviolet radiation, oral administration of Taohong purpura decoction combined with halomethasone cream and ultraviolet radiation could control the disease quickly and avoid further development of the disease at the early stage of treatment. The treatment of vitiligo of qi stagnation and blood stasis type by internal administration of Taohong white purpura prescription combined with halomethasone cream and ultraviolet radiation was superior to oral Boshiba tablet combined with halomethasone cream and ultraviolet irradiation. It is effective to treat vitiligo with Qi stagnation and blood stasis, and can improve and stabilize the patient's condition early, and the patients' blood, urine, stool routine, liver and kidney function index are in normal range, clinical safety is good, it is worth further popularizing.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R275.9

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