本文選題：芪地復(fù)腎湯 + 慢性腎小球腎炎�。� 參考：《長(zhǎng)春中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察芪地復(fù)腎湯治療CGN蛋白尿脾腎氣虛證的臨床療效。方法:收集2014年6月至2015年12月吉林省人民醫(yī)院中醫(yī)科、腎病科門診及療區(qū)患者病人,入選患者均符合CGN的臨床診斷,共納入80例,研究過程中脫落8例,最終研究病例72例。所有患者隨機(jī)分為中藥治療組、對(duì)照組各36例。所有患者均予以一般基礎(chǔ)治療,中藥治療組治療方案:給予芪地復(fù)腎湯(采用三九藥業(yè)生產(chǎn)的中藥免煎制劑),按照原飲片量調(diào)劑,水沖300 ml,每日1劑,早飯前、晚飯后分服;對(duì)照組治療方案:給予洛汀新10 mg,每日1次。兩組觀察時(shí)間為12周。對(duì)比兩組患者治療后尿蛋白水平、中醫(yī)癥狀變化,評(píng)價(jià)兩組整體療效。結(jié)果:經(jīng)治后,中藥治療組患者治愈7例,顯效15例,有效12例,總有效率為94.4%,明顯優(yōu)于對(duì)照組(P0.05),差異有統(tǒng)計(jì)學(xué)意義;兩組患者中醫(yī)主證均有不同程度好轉(zhuǎn),在浮腫、乏力、便溏、納差等方面,中藥治療組的好轉(zhuǎn)程度明顯優(yōu)于對(duì)照組(P0.05),差異有統(tǒng)計(jì)學(xué)意義;對(duì)24 h尿蛋白定量進(jìn)行比較,兩組經(jīng)治后均有一定的降蛋白作用,中藥治療組明顯優(yōu)于對(duì)照組(P0.05);中藥治療組尿蛋白水平下降效果明顯優(yōu)于對(duì)照組(P0.05),差異有統(tǒng)計(jì)學(xué)意義;治療前后兩組的AST、ALT、BUN及SCr比較差異無統(tǒng)計(jì)學(xué)意義(P0.05);兩組治療前后血常規(guī)、糞常規(guī)檢查均未見明顯異常。研究過程中,兩組均未見不良反應(yīng)。結(jié)論:芪地復(fù)腎湯可有效降低CGN脾腎氣虛證患者蛋白尿水平,改善慢性腎炎的臨床癥狀,提高患者生存質(zhì)量。本研究觀察應(yīng)用芪地復(fù)腎湯對(duì)肝、腎功能未見明顯影響,未見明顯不良反應(yīng),安全性較好。
[Abstract]:Objective: to observe the clinical effect of Qidi Fushen decoction in treating CGN proteinuria with deficiency of spleen and kidney qi.Methods: from June 2014 to December 2015, the patients in the Department of traditional Chinese Medicine, the Department of Renal Diseases and the treatment area of Jilin Provincial people's Hospital were collected. All the patients were selected according to the clinical diagnosis of CGN, including 80 cases, 8 cases were lost in the course of the study, and 72 cases were finally studied.All patients were randomly divided into Chinese medicine treatment group, the control group of 36 cases.All the patients were given general basic treatment, the Chinese medicine treatment group was given Qidi Fushen decoction (using Sanjiu pharmaceutical industry production of Chinese medicine free decoction preparation, according to the original decoction volume, 300 ml water, 1 dose per day, before breakfast, after supper;The control group was treated with Lotensin 10 mg once a day.The observation time was 12 weeks.The urine protein level and TCM symptoms were compared between the two groups after treatment, and the overall curative effect of the two groups was evaluated.Results: after treatment, 7 cases were cured, 15 cases were effective, 12 cases were effective, the total effective rate was 94.44.The total effective rate was 94.44.The difference was statistically significant.In the aspects of loose stools and poor anorexia, the improvement of TCM treatment group was significantly better than that of control group (P 0.05), and the difference was statistically significant.The Chinese medicine treatment group was obviously superior to the control group (P 0.05A), the Chinese medicine treatment group had significantly better effect than the control group (P 0.05) in decreasing the urine protein level, the difference between the two groups was statistically significant, there was no significant difference between the two groups in AST alt bun and SCr before and after treatment, and there was no significant difference in blood routine before and after treatment between the two groups, and there was no significant difference between the two groups before and after treatment.No obvious abnormality was found in routine examination of feces.In the course of the study, no adverse reactions were observed in either group.Conclusion: Qidi Fushen decoction can effectively reduce the level of proteinuria in CGN patients with deficiency of spleen and kidney qi, improve the clinical symptoms of chronic nephritis and improve the quality of life of the patients.In this study, Qidi Fushen decoction had no obvious effect on liver and kidney function, no obvious adverse reaction, and good safety.
【學(xué)位授予單位】：長(zhǎng)春中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R277.5

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