本文選題：金匱腎氣丸加味方 + 金匱腎氣丸　； 參考：《山東中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:本臨床研究旨在對比金匱腎氣丸原方及其加味方治療糖尿病腎病IV期的臨床療效。方法:將入選的72例病例,按隨機(jī)數(shù)表法分為治療組36例,對照組36例。治療組在基礎(chǔ)治療上予金匱腎氣丸加味方,對照組在基礎(chǔ)治療上予金匱腎氣丸原方,觀察分析兩組的中醫(yī)癥狀及實(shí)驗(yàn)室指標(biāo)變化情況,對比兩組的臨床療效。結(jié)果:(1)治療組與對照組總有效率分別為76.67%和46.67%,兩組對比有顯著性差異,治療組明顯優(yōu)于對照組;(2)治療組在改善中醫(yī)癥狀方面明顯優(yōu)于對照組,兩組相比差異顯著;(3)兩組自身治療前后空腹血糖(FBG)、餐后2小時(shí)血糖(PBG)、糖化血紅蛋白(HbA1c)均有明顯下降,治療后兩組餐后2小時(shí)血糖(PBG)相比無統(tǒng)計(jì)學(xué)意義,治療后治療組FBG下降優(yōu)于對照組,具有統(tǒng)計(jì)學(xué)意義,治療后治療組HbA1c下降明顯優(yōu)于對照組,具有極顯著性差異;(4)兩組治療后24h尿蛋白定量與治療前相比有所改善,組間對比亦具統(tǒng)計(jì)學(xué)意義;(5)治療后兩組血尿素氮(BUN)、血肌酐(Scr)水平與治療前比較均有明顯下降,且治療組下降趨勢明顯優(yōu)于對照組,治療后兩組血內(nèi)生肌酐清除率(Ccr)較治療前明顯均上升,組間對比亦具極顯著性差異。結(jié)論:金匱腎氣丸加味方與原方相比,可更明顯改善糖尿病腎病IV期患者臨床癥狀,維持血糖穩(wěn)定,減少尿蛋白,改善水腫情況,延緩腎功能惡化。
[Abstract]:Objective: to compare the clinical effect of Jinkui Shenqi Pill and its Jiawei prescription on stage IV diabetic nephropathy.Methods: 72 cases were randomly divided into treatment group (36 cases) and control group (36 cases).The treatment group was treated with Jinkui Shenqi Pill on basic treatment and the control group with Jinkui Shenqi Pill on basic treatment. The changes of TCM symptoms and laboratory indexes in the two groups were observed and analyzed, and the clinical efficacy of the two groups was compared.Results the total effective rates of the treatment group and the control group were 76.67% and 46.67%, respectively. There was significant difference between the two groups, and the treatment group was obviously superior to the control group in improving the symptoms of traditional Chinese medicine.There was a significant difference between the two groups (P < 0.05). The fasting blood glucose (FBGG), blood glucose (PBG) and HbA1c (2 hours postprandial blood glucose) in the two groups were significantly decreased before and after treatment, but there was no significant difference between the two groups after treatment.After treatment, the decrease of FBG in the treatment group was better than that in the control group, and the decrease of HbA1c in the treatment group was significantly better than that in the control group.The blood urea nitrogen bun and creatinine (SCR) levels in the two groups were significantly lower than those before the treatment, and the decreasing trend of the treatment group was obviously better than that of the control group.After treatment, the creatinine clearance rate (CcrR) in the two groups was significantly higher than that before treatment, and there was also a significant difference between the two groups.Conclusion: compared with the original prescription, Jingui Shenqi Pill can significantly improve the clinical symptoms of patients with stage IV diabetic nephropathy, maintain stable blood glucose, reduce urine protein, improve edema and delay the deterioration of renal function.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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