發(fā)布時(shí)間：2018-04-13 20:08

  本文選題：尋常型銀屑病 + 中醫(yī)辨治�。� 參考：《河南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:通過對新的證治體系與經(jīng)典的證治體系的療效差異的大樣本觀察,總結(jié)出更客觀、更有效的銀屑病治療體系,提高尋常型銀屑病的辨證與治療水平。方法:本項(xiàng)目采用前瞻性、大樣本、隨機(jī)平行對照的臨床試驗(yàn)設(shè)計(jì),大樣本觀察新的證治體系與經(jīng)典的證治體系的療效差異。擬納入尋常型銀屑病患者300例,病例資料均來自于2014年10月至2015年12月我科門診,隨機(jī)分為新體系辨證治療組和經(jīng)典體系對照組。新體系辨證治療組嚴(yán)格按照新體系進(jìn)行辨證用藥(詳見表2新體系具體處方用藥標(biāo)準(zhǔn)),給予相應(yīng)中藥免煎顆粒,每日一劑,分早晚兩次飯后溫服;經(jīng)典體系辨證治療組嚴(yán)格按照經(jīng)典體系辨證用藥(詳見表1經(jīng)典體系具體處方用藥標(biāo)準(zhǔn)),給予相應(yīng)中藥免煎顆粒,每日一劑,分早晚兩次飯后溫服。所有納入患者均外用卡泊三醇軟膏和糠酸莫米松軟膏混合外涂,每日早晚兩次抹。采用國際公認(rèn)的PASI評分標(biāo)準(zhǔn)和國內(nèi)權(quán)威的療效評定標(biāo)準(zhǔn)進(jìn)行客觀的療效評價(jià),運(yùn)用spass19.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)分析。新體系辨證治療組和經(jīng)典體系辨證治療組的平均年齡比較用獨(dú)立樣本t檢驗(yàn),性別比較用χ2檢驗(yàn),初診pasi評分比較用獨(dú)立樣本t檢驗(yàn),最后對兩組療效差異比較用χ2檢驗(yàn),從臨床、安全性等方面客觀評價(jià)兩組療效的差異。結(jié)果:兩組療效結(jié)果在治療2、4、6、8周后進(jìn)行評估,療效評價(jià)時(shí),治愈與顯效病例合計(jì)為有效病例,計(jì)算有效率。其中新體系治療組予2、4、6、8周時(shí)有效率分別是16.67%、42.36%、72.22%、89.58%;經(jīng)典體系治療組予2、4、6、8周時(shí)有效率分別是2.08%、4.86%、15.28%、53.47%;兩組療效經(jīng)χ2檢驗(yàn)結(jié)果2、4、6、8周P值均是P0.05,差異有統(tǒng)計(jì)學(xué)意義,又加上各時(shí)間節(jié)點(diǎn)新體系治療組有效率均高于經(jīng)典體系治療組有效率,所以新體系治療組療效優(yōu)于經(jīng)典體系治療組療效。結(jié)論:臨床試驗(yàn)證明新的證治體系療效優(yōu)于經(jīng)典的證治體系。
[Abstract]:Objective: to summarize a more objective and effective psoriasis treatment system by observing the difference of therapeutic effect between the new syndrome system and the classical one, and to improve the level of syndrome differentiation and treatment of psoriasis vulgaris.Methods: a prospective, large sample, randomized, parallel control clinical trial design was used to observe the difference of therapeutic effect between the new syndrome and treatment system and the classical treatment system.A total of 300 patients with psoriasis vulgaris were included. The data were collected from October 2014 to December 2015. They were randomly divided into two groups: the new system syndrome differentiation treatment group and the classical system control group.The new system syndrome differentiation treatment group strictly according to the new system according to the new system for the treatment of syndrome differentiation (see Table 2, the new system specific prescription drug standard, given the corresponding Chinese medicine free decoction granules, one dose daily, divided into morning and evening twice after the meal warm clothes;The treatment group of classic syndrome differentiation was strictly in accordance with the classic system. (for details, see Table 1, the specific prescription standard of the classic system, give the corresponding Chinese medicine free decoction granules, one dose daily, divided into morning and evening, two times after meal warm clothes.All patients were treated externally with carpotriol ointment and momethasone furoate ointment twice a day.The objective evaluation of curative effect was carried out by using the internationally accepted PASI scoring standard and the domestic authoritative evaluation standard of curative effect, and the statistical analysis was carried out by using the spass19.0 statistical software.The average age of the new system syndrome differentiation treatment group and the classical system syndrome differentiation treatment group were compared by independent sample t test, sex comparison by 蠂 2 test, pasi score by independent sample t test, and the difference of curative effect between the two groups by 蠂 2 test.Objective evaluation of the two groups from clinical, safety and other aspects of the difference in efficacy.Results: the results of the two groups were evaluated after 8 weeks of treatment. In the evaluation of curative effect, the cases of cure and obvious effect were all effective cases, and the effective rate was calculated.The effective rates of the new system treatment group at 8 weeks were 16.67 and 42.36 and 72.22 and 89.58, respectively; the effective rates of the classical system treatment group at 8 weeks were 2.08 and 4.86, 15.28 and 53.47, respectively. The results of 蠂 2 test showed that the effective rates of the two groups were all P 0.05, and the difference was statistically significant.In addition, the effective rate of the new system treatment group is higher than that of the classical system treatment group, so the new system treatment group is superior to the classical system treatment group.Conclusion: the clinical trial proves that the new syndrome treatment system is superior to the classical syndrome treatment system.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R275.9

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