本文選題：益氣活血方　切入點(diǎn)：氣虛血瘀　出處：《中藥材》2017年01期

【摘要】：目的:考察益氣活血方對(duì)氣虛血瘀型慢性心衰的療效及可能機(jī)理。方法:收集2015年4月~2016年3月在四川省人民醫(yī)院住院治療并確診的慢性心衰患者135例,按入院順序隨機(jī)分為2組,對(duì)照組65例,觀察組70例,兩組均予強(qiáng)心、利尿、擴(kuò)血管及ACEI類藥物治療,觀察組在對(duì)照組基礎(chǔ)上給予益氣活血方,兩組均治療4 w。結(jié)果:治療前兩組患者心功能、6 min步行距離、腎素(REN)、血管緊張素Ⅱ(AngⅡ)、醛固酮(ALD)、末端腦利納肽前體(NT-pro BNP)及中醫(yī)證候積分差異無統(tǒng)計(jì)學(xué)意義(P0.05),治療后兩組患者心功能、6 min步行距離、REN、AngⅡ、ALD、NT-pro BNP及中醫(yī)證候積分均顯著改善(P0.05),與對(duì)照組比較,觀察組改善更顯著(P0.05),且觀察組總有效率顯著高于對(duì)照組(P0.05)。2組患者均未發(fā)生嚴(yán)重的不良反應(yīng)。結(jié)論:益氣活血方可改善CHF患者心功能,具有逆轉(zhuǎn)心肌重構(gòu)的作用,其機(jī)理可能與抑制激活的RAAS和NT-pro BNP有關(guān)。
[Abstract]:Objective: to investigate the effect and possible mechanism of Yiqi Huoxue recipe on chronic heart failure with qi deficiency and blood stasis.Methods: 135 patients with chronic heart failure (CHF) who were hospitalized in Sichuan Provincial people's Hospital from April 2015 to March 2016 were randomly divided into two groups: control group (n = 65) and observation group (n = 70).The observation group was treated with Yiqi Huoxue decoction on the basis of the control group, both groups were treated for 4 weeks.Results: before treatment, the cardiac function of the two groups was 6 min walking distance.There was no significant difference in renin, angiotensin 鈪，

本文編號(hào)：1729369