本文選題：腎癌　切入點：慢性腎臟病　出處：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過觀察應(yīng)用益腎泄?jié)釡委熌I癌術(shù)后合并慢性腎臟病(CKD2-3期)脾腎兩虛、濁毒內(nèi)蘊證患者的治療前后癥狀,其腎功、癌胚抗原和D-二聚體水平的變化,探討其臨床療效。方法:收集符合篩選標(biāo)準(zhǔn)的患者30例,全部患者均來自黑龍江中醫(yī)藥大學(xué)附屬第一醫(yī)院腎病科門診�；颊呷虢M后應(yīng)用益腎泄?jié)釡委?4周為一療程,共6個療程。觀察對比患者治療前后癥狀,肌酐、尿素氮、內(nèi)生肌酐清除率、CEA和D-二聚體的變化。結(jié)果:1.治療6個月后臨床癥狀明顯緩解,P0.01,有顯著差異,具有統(tǒng)計學(xué)意義。2.Scr、BUN、Ccr數(shù)據(jù)均符合正態(tài)性,治療中與治療結(jié)束后兩組Scr、BUN較治療前均降低(P0.05),Ccr升高(P0.05),差異具有統(tǒng)計學(xué)意義。3.CEA和D-二聚體數(shù)據(jù)均符合正態(tài)性,治療6個療程后明顯低于治療前(P0.05),差異具有統(tǒng)計學(xué)意義。結(jié)論:1.應(yīng)用益腎泄?jié)釡捎行Ц纳颇I癌術(shù)后合并慢性腎臟病(2-3期)脾腎兩虛、濁毒內(nèi)蘊證患者的癥狀。2.應(yīng)用益腎泄?jié)釡谝欢ǔ潭壬峡筛纳苹颊叩哪I功、CEA和D-二聚體。
[Abstract]:Objective: to observe the changes of renal function, carcinoembryonic antigen and D-dimer in patients with deficiency of spleen and kidney and accumulation of turbid toxin after treatment with Yishen Xiezhuo decoction (Yishen Xiezhuo decoction). Methods: 30 patients who met the screening criteria were collected, all of whom were from the Department of Renal Department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. The patients were treated with Yishen Xiezhuo decoction for 4 weeks as a course of treatment. The changes of symptoms, creatinine, urea nitrogen, endogenous creatinine clearance rate CEA and D-dimer were observed and compared before and after treatment for 6 courses. The results showed that Scr-BUNC CCR data were in accordance with normal distribution, and Scr-bun levels in both groups were significantly lower than those before treatment. The difference was statistically significant. 3. CEA and D- dimer data were consistent with normal distribution. After 6 courses of treatment, it was significantly lower than that before treatment (P 0.05), and the difference was statistically significant. Conclusion: 1. The deficiency of spleen and kidney can be effectively improved by applying Yishen Xiezhuo decoction after operation of renal carcinoma complicated with chronic kidney disease at 2-3 stage. Application of Yishen Xiezhuo decoction can improve the renal function of patients with CEA and D-dimer to a certain extent.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R277.5

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