本文選題：玫瑰糠疹　切入點(diǎn)：消風(fēng)散加減　出處：《安徽中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:采用消風(fēng)散加減聯(lián)合窄譜中波紫外線治療風(fēng)熱蘊(yùn)膚型玫瑰糠疹,觀察該療法在改善皮損積分、瘙癢程度等方面的作用,并觀察其安全性和對(duì)復(fù)發(fā)情況的影響,分析消風(fēng)散加減與窄譜中波紫外線聯(lián)合使用治療玫瑰糠疹的優(yōu)勢(shì)。方法:按照隨機(jī)數(shù)字法將60例玫瑰糠疹屬風(fēng)熱蘊(yùn)膚證的患者分為兩組:治療組(采用消風(fēng)散加減聯(lián)合窄譜中波紫外線照射)30例,對(duì)照組(依巴斯汀片聯(lián)合窄譜中波紫外線照射)30例,2周為一個(gè)療程,治療1~2個(gè)療程,紅斑消退后停止窄譜中波紫外線照射,口服藥繼續(xù)使用,療程結(jié)束后隨訪1個(gè)月。觀察并記錄患者的皮損、瘙癢程度、起效時(shí)間、安全性及不良反應(yīng)、復(fù)發(fā)等情況,并監(jiān)測(cè)血、尿常規(guī)和肝、腎功能。比較患者治療前、治療2周末、治療4周末的PRSS積分、療效指數(shù)、瘙癢程度、起效時(shí)間、安全性及不良反應(yīng)、復(fù)發(fā)等情況。結(jié)果:(1)治療組與對(duì)照組患者年齡、性別、病程、治療前PRSS積分、治療前瘙癢程度組間比較,均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);(2)與治療前比較,兩組患者治療2周后的PRSS積分均有統(tǒng)計(jì)學(xué)差異(P0.05),與治療2周后比較,兩組患者治療4周后的PRSS積分均有統(tǒng)計(jì)學(xué)差異(P0.05),與對(duì)照組比較,治療組治療2周后、治療4周后的PRSS積分有統(tǒng)計(jì)學(xué)差異(P0.05);(3)與治療2周后比較,兩組患者治療4周后的療效均有統(tǒng)計(jì)學(xué)差異(P0.05),與對(duì)照組比較,治療組在治療2周后、治療4周后的療效有統(tǒng)計(jì)學(xué)差異(P0.05);(4)與治療2周后比較,兩組患者治療4周后的瘙癢程度均有統(tǒng)計(jì)學(xué)差異(P0.05),與治療組比較,對(duì)照組治療2周后的瘙癢程度有統(tǒng)計(jì)學(xué)差異(P0.05),對(duì)照組治療4周后的瘙癢程度無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);(5)與對(duì)照組比較,治療組的起效時(shí)間和照光次數(shù)有統(tǒng)計(jì)學(xué)差異(P0.05);(6)兩組患者在用藥安全性和不良反應(yīng)方面無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。治療過(guò)程中兩組均出現(xiàn)1例胃部不適,治療組和對(duì)照組各出現(xiàn)2例和1例輕度紅斑反應(yīng);(7)與對(duì)照組比較,治療組的復(fù)發(fā)情況有統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:消風(fēng)散加減聯(lián)合窄譜中波紫外線照射治療風(fēng)熱蘊(yùn)膚型玫瑰糠疹療效確切,可以改善患者皮損的PRSS積分、瘙癢程度,且安全性好,不良反應(yīng)少、復(fù)發(fā)率低,能夠安全有效地治療玫瑰糠疹。
[Abstract]:Objective: to observe the effect of Xiaofeng San plus or subtraction combined with narrow-spectrum ultraviolet B on treating wind-heat skin type pityriasis roseus, and to observe the effect of the therapy on improving the score of skin lesion and the degree of pruritus, as well as its safety and influence on recurrence.To analyze the advantages of the combination of Xiaofeng San and narrow band ultraviolet B in treating pityriasis roseus.Methods: according to the random number method, 60 patients with pityriasis roseus were divided into two groups: treatment group (30 cases were treated with Xiaofeng Powder plus subtraction combined with narrow-spectrum ultraviolet B radiation),In the control group, 30 cases of Ebastine tablet combined with narrow-band ultraviolet B radiation were treated for 1 ~ 2 courses of treatment for 2 weeks. After erythema subsided, the treatment stopped the narrow band ultraviolet B radiation, and the oral drug was continued to be used, followed up for 1 month after the end of the course of treatment.To observe and record the lesions, the degree of pruritus, the onset time, the safety, adverse reactions, recurrence and so on, and to monitor the blood, urine routine and liver and renal function.The PRSS score, curative effect index, pruritus degree, onset time, safety, adverse reaction and recurrence were compared before and after treatment for 2 weeks and 4 weeks.Results there was no significant difference in age, sex, course of disease, PRSS score before treatment and the degree of pruritus between the treatment group and the control group (P 0.05).There were significant differences in PRSS scores between the two groups after 2 weeks of treatment (P 0.05). Compared with the two groups after 2 weeks of treatment, the PRSS scores of the two groups were significantly different after 4 weeks of treatment (P 0.05). Compared with the control group, the treatment group had two weeks of treatment.There were significant differences in PRSS scores after 4 weeks of treatment (P 0.05) and after 2 weeks of treatment. There were significant differences in the curative effects between the two groups after 4 weeks of treatment (P 0.05). Compared with the control group, the treatment group had a significant difference after 2 weeks of treatment, and compared with the control group, the treatment group had a significant difference after 2 weeks of treatment.There was a significant difference in the curative effect between the two groups after 4 weeks of treatment (P 0.05) and the degree of pruritus in the two groups was significantly different from that in the treatment group after 4 weeks of treatment (P 0.05), and compared with that in the treatment group (P < 0.05), and there was no significant difference in the degree of pruritus between the two groups.The degree of pruritus in the control group was significantly different from that in the control group after 2 weeks of treatment (P 0.05), but the degree of pruritus in the control group was not significantly different from that in the control group after 4 weeks of treatment.There was no significant difference in drug safety and adverse reactions between the two groups (P 0.05).In the course of treatment, 1 case of gastric discomfort appeared in both groups, 2 cases and 1 case of mild erythema reaction occurred in treatment group and control group, respectively. Compared with control group, the recurrence rate of treatment group was significantly different from that of control group (P 0.05).Conclusion: Xiaofeng Powder plus or minus combined with narrow-spectrum ultraviolet B irradiation is effective in the treatment of wind-heat skin type pityriasis roseus. It can improve the PRSS score, the degree of pruritus, the safety, the less adverse reactions and the low recurrence rate.It can treat pityriasis roseus safely and effectively.
【學(xué)位授予單位】：安徽中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R275.9

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