本文選題：EMT盆腔疼痛　切入點(diǎn)：濕熱瘀阻型　出處：《成都中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：以孕三烯酮為對(duì)照組,觀察內(nèi)異康復(fù)片治療濕熱瘀阻型子宮內(nèi)膜異位癥(EMT)盆腔疼痛的臨床療效,為濕熱瘀阻型EMT盆腔疼痛的中醫(yī)藥治療提供有效的治療思路及臨床用藥依據(jù)。方法：將符合EMT濕熱瘀阻型診斷標(biāo)準(zhǔn)的72例患者,隨機(jī)分為治療組與對(duì)照組,治療組予內(nèi)異康復(fù)片口服,對(duì)照組予孕三烯酮膠囊口服,均用藥3個(gè)月。觀察兩組治療前后各癥狀體征積分及相關(guān)療效指標(biāo)和安全性指標(biāo)變化情況。結(jié)果：(1)單項(xiàng)指標(biāo)療效比較：在縮小卵巢巧克力囊腫直徑方面,兩組組內(nèi)比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；組間比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),對(duì)照組優(yōu)于治療組。在降低血清腫瘤標(biāo)記物CA-125水平方面,兩組組內(nèi)比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；組間比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療組與對(duì)照組療效相當(dāng)。在EMT患者生存質(zhì)量量表評(píng)分方面,治療前后組內(nèi)比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),兩組均可改善EMT患者的生活質(zhì)量。(2)兩組主癥療效比較：治療組總有效率為91.5%：對(duì)照組總有效率為88.6%;組內(nèi)比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；組間比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療組與對(duì)照組療效相當(dāng)。(3)兩組中醫(yī)證候療效比較：治療組總有效率為88.6%；對(duì)照組總有效率為60.0%；組內(nèi)比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);組間比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療組療效優(yōu)于對(duì)照組。(4)兩組局部體征療效比較：治療組總有效率為88.6%：對(duì)照組總有效率為85.7%,組內(nèi)比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)：組間比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療組與對(duì)照組療效相當(dāng)。(5)兩組綜合療效比較：治療組總有效率為88.6%：對(duì)照組總有效率為80.0%,組內(nèi)比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；組間比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療組療效優(yōu)于對(duì)照組。(6)安全性結(jié)果分析：本實(shí)驗(yàn)對(duì)照組共出現(xiàn)2例不良事件,考慮與藥物有關(guān)；治療組則未出現(xiàn)不良反應(yīng)。結(jié)論：(1)治療組與對(duì)照組在治療EMT所致的盆腔疼痛、降低血清CA-125水平、緩解該病的局部體征方面療效相當(dāng),二者均可以改善EMT患者的生活質(zhì)量；(2)治療組治療濕熱瘀阻型EMT的中醫(yī)證候療效、綜合療效明顯優(yōu)于對(duì)照組,而且副作用少。(3)內(nèi)異康復(fù)片治療濕熱瘀阻證EMT安全有效,值得臨床推廣。
[Abstract]:Objective: to observe the clinical effect of Neiyikangfu tablet on pelvic pain of endometriosis with damp-heat ecchymosis as control group. Methods: 72 patients with damp-heat stasis type EMT pelvic pain were randomly divided into treatment group and control group. The treatment group was treated with Nei Yi Kang tablet and the control group with pregnancy trienone capsule. All patients were treated for 3 months. The changes of the scores of symptoms and signs, the related curative effect indexes and the safety indexes before and after treatment were observed. Results comparison of the single index: in reducing the diameter of ovarian chocolate cyst, the difference between the two groups was compared. The difference was statistically significant (P 0.05), the difference was statistically significant (P 0.05), and the control group was superior to the treatment group (P 0.05). There was a significant difference between the two groups in reducing the serum tumor marker CA-125 level (P 0.05), and the difference between the two groups was significant (P 0.05). The difference was not statistically significant (P 0.05). The curative effect of the treatment group was similar to that of the control group. In terms of quality of life (QOL) score of patients with EMT, there was a comparison between the two groups before and after treatment. The difference was statistically significant (P 0.05). Both groups could improve the quality of life (QOL) of EMT patients. The curative effects of the two groups were as follows: the total effective rate in the treatment group was 91.5 and the total effective rate in the control group was 88.60.The difference was statistically significant in intra-group comparison (P 0.05). There was no significant difference between the two groups (P 0.05). The curative effect of the treatment group was similar to that of the control group. (3) the total effective rate of the treatment group was 88.6; the total effective rate of the control group was 60.0; the difference within the group was statistically significant; the difference between the two groups was statistically significant; and between the two groups, the total effective rate of the treatment group was 88.60.The total effective rate of the control group was 60.05g. The difference was statistically significant (P 0.05). The curative effect of the treatment group was better than that of the control group. (4) the total effective rate of the treatment group was 88.6; the total effective rate of the control group was 85.7%; the difference between the two groups was statistically significant (P 0.05). The total effective rate of the treatment group was 88.6; the total effective rate of the control group was 80.05.There was significant difference between the treatment group and the control group (P 0.05). The difference was statistically significant (P 0.05). The efficacy of the treatment group was better than that of the control group. (6) Analysis of the safety results: there were 2 cases of adverse events in this experimental control group, considering drug related; Conclusion the treatment group and the control group have the same efficacy in the treatment of pelvic pain caused by EMT, the reduction of serum CA-125 level, and the relief of local signs of the disease. Both of them could improve the quality of life of patients with EMT. (2) in the treatment group, the TCM syndromes of dampness and heat stasis type EMT were obviously superior to those in the control group, and the side effects were less. 3) Neishikangfu tablet was safe and effective in the treatment of dampness and heat stasis syndrome EMT. It is worth popularizing in clinic.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R271.9

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