本文選題：加減金剛丸　切入點(diǎn)：強(qiáng)直性脊柱炎　出處：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:觀察加減金剛丸對(duì)腎陽虧虛證強(qiáng)直性脊柱炎患者的臨床療效及安全性。方法:對(duì)符合納入標(biāo)準(zhǔn)的62例腎陽虧虛證強(qiáng)直性脊柱炎患者應(yīng)用加減金剛丸湯劑日兩次口服連續(xù)治療3個(gè)月,記錄治療前后中醫(yī)證候積分、疼痛VAS積分、BASFI積分、BASDAI中晨僵積分,Schober試驗(yàn)結(jié)果、血沉與c反應(yīng)蛋白水平,采用SPSS17.0統(tǒng)計(jì)軟件對(duì)結(jié)果進(jìn)行分析。結(jié)果:1.以加減金剛丸治療腎陽虧虛證強(qiáng)直性脊柱炎患者3個(gè)月,達(dá)到ASAS20的緩解率為72.58%,中醫(yī)判定標(biāo)準(zhǔn)得到的總有效率為90.32%。2.加減金剛丸可有效降低患者疼痛VAS積分、BASFI積分、BASDAI中晨僵積分,與治療前相比有統(tǒng)計(jì)學(xué)意義(p0.05)。3.加減金剛丸可改善腎陽虧虛證強(qiáng)直性脊柱炎患者腰椎活動(dòng)度,增加患者Schober試驗(yàn)數(shù)值,與治療前相比有統(tǒng)計(jì)學(xué)意義(p0.05)。4.加減金剛丸可降低患者血沉與c反應(yīng)蛋白水平,與治療前相比有統(tǒng)計(jì)學(xué)意義(p0.05)。5.加減金剛丸可顯著降低患者中醫(yī)證候積分,與治療前相比有統(tǒng)計(jì)學(xué)意義(p0.05)。6.加減金剛丸治療腎陽虧虛證強(qiáng)直性脊柱炎未見明顯副作用,安全性較好。結(jié)論:加減金剛丸可明顯降低腎陽虧虛證強(qiáng)直性脊柱炎患者的中醫(yī)證候積分,可降低患者疼痛VAS積分、BASFI積分、BASDAI中晨僵積分,改善Schober試驗(yàn)結(jié)果,降低患者血沉與c反應(yīng)蛋白水平。
[Abstract]:Objective: to observe the clinical efficacy and safety of Jiajiangjingangwan in treating ankylosing spondylitis with deficiency of kidney-yang syndrome. Methods: 62 cases of ankylosing spondylitis with deficiency of kidney-yang deficiency syndrome were treated with Additive and subtractive Jin-Kong Pill decoction day. Two consecutive oral treatments for three months, The score of TCM syndromes before and after treatment, the VAS integral of pain and the score of morning stiffness in BASDAI were recorded, and the levels of erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) were also recorded. SPSS17.0 statistical software was used to analyze the results. Results: 1.The treatment of ankylosing spondylitis with deficiency of kidney-yang for 3 months was treated by adding or subtracting Jingang pills. The remission rate of ASAS20 is 72.58 and the total effective rate of TCM judgment standard is 90.32 and 2.The addition and subtraction of Jingang pills can effectively reduce the VAS integral of pain and the integral of BASFI and the morning stiffness integral in BASDAI. Compared with before treatment, there was significant difference between before treatment and before treatment. The addition and subtraction of Jingang pills could improve the lumbar vertebra activity and increase the value of Schober test in patients with ankylosing spondylitis of deficiency of kidney-yang syndrome. Compared with before treatment, there was a significant difference between before treatment and before treatment. Addition and subtraction of Jingang pills could decrease the level of ESR and c reactive protein in patients, and had statistical significance compared with those before treatment. Addition and subtraction of Jingang pills could significantly reduce the score of TCM syndromes of patients. Compared with before treatment, there was a significant difference between before treatment and before treatment. There was no significant side effect in the treatment of ankylosing spondylitis due to deficiency of kidney-yang in addition and subtraction of Jingang pills. Conclusion: addition and subtraction of Jingang pills can significantly reduce the syndrome score of ankylosing spondylitis with deficiency of kidney-yang syndrome, reduce the VAS integral of pain and improve the results of Schober test. The levels of ESR and c-reactive protein were decreased.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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