本文選題：激光散斑　切入點(diǎn)：糖尿病并發(fā)癥　出處：《遼寧中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:應(yīng)用激光散斑成像技術(shù)觀察單純2型糖尿病患者以及糖尿病合并動(dòng)脈硬化癥、腎病、周圍神經(jīng)病變、視網(wǎng)膜病變等不同合并癥患者的舌象微循環(huán),以探討微循環(huán)障礙對(duì)糖尿病及其慢性并發(fā)癥的影響,以及影響糖尿病微循環(huán)障礙的相關(guān)危險(xiǎn)因素。并從瘀血致病的角度,來研究其在糖尿病及其慢性并發(fā)癥中發(fā)揮的作用,為中醫(yī)藥干預(yù)治療提供理論依據(jù)。材料與方法:對(duì)2014年4月至2014年7月在遼寧中醫(yī)藥大學(xué)附屬醫(yī)院內(nèi)分泌科住院的2型糖尿病患者60例,進(jìn)行詳細(xì)的一般資料采集,測(cè)量患者的身高體重,計(jì)算體重指數(shù),測(cè)量腰圍,收集患者入院的理化檢查結(jié)果,然后應(yīng)用MOOR FLPI2變焦激光散斑血流實(shí)時(shí)成像系統(tǒng),選取受試者舌尖、舌根及舌的左右兩側(cè)四個(gè)位置,分別測(cè)量記錄其舌體血流量及血流面積。應(yīng)用spss17.0軟件包進(jìn)行統(tǒng)計(jì)分析,以探討單純2型糖尿病患者與2型糖尿病合并不同合并癥患者舌象微循環(huán)的異同,以及相關(guān)因素與2型糖尿病患者舌象微循環(huán)的相關(guān)性。結(jié)果:1.合并2種及3種并發(fā)癥患者的舌體平均血流量均低于單純2型糖尿病組患者的舌體平均血流量(P0.05)。合并3種并發(fā)癥患者的舌體平均血流面積小于單純2型糖尿病患者及合并1種2種并發(fā)癥組患者的舌體平均血流面積(P0.05)。2.合并周圍神經(jīng)病變和(或)動(dòng)脈硬化組患者的舌體平均血流量低于單純2型糖尿病患者的舌體平均血流量(P0.05),合并周圍神經(jīng)病變和(或)動(dòng)脈硬化組組患者的舌體平均血流面積小于單純2型糖尿病患者的舌體平均血流(P0.05)。3.患者舌體平均血流量與患者血尿酸、腰圍、C肽(空腹)、C肽(餐后2h)水平呈負(fù)相關(guān)(P0.05)。結(jié)論:1.糖尿病患者合并相關(guān)并發(fā)癥后舌象微循環(huán)障礙加重,且隨著并發(fā)癥種類的增多嚴(yán)重程度增加。周圍神經(jīng)病變、動(dòng)脈硬化癥為導(dǎo)致2型糖尿病患者微循環(huán)障礙的主要并發(fā)癥。中醫(yī)瘀血在2型糖尿病患者并發(fā)癥的發(fā)生發(fā)展過程中起重要作用。2.高血尿酸、肥胖是導(dǎo)致2型糖尿病患者微循環(huán)障礙的重要危險(xiǎn)因素。3.糖尿病患者的微循環(huán)障礙程度,隨著空腹C肽和餐后2h C肽水平的增加而加重。
[Abstract]:Objective: to observe the tongue microcirculation in patients with type 2 diabetes mellitus and diabetic patients with arteriosclerosis, nephropathy, peripheral neuropathy and retinopathy by laser speckle imaging. To study the effect of microcirculation disorder on diabetes mellitus and its chronic complications, and the related risk factors of diabetic microcirculation disorder, and to study the role of microcirculation disorder in diabetes mellitus and its chronic complications from the point of view of blood stasis. Materials and methods: from April 2014 to July 2014, 60 patients with type 2 diabetes mellitus in the Department of Endocrinology, affiliated Hospital of Liaoning University of traditional Chinese Medicine, were collected. The height and weight of the patients were measured, the body mass index was calculated, the waist circumference was measured, the physical and chemical examination results of the patients were collected, and then the tongue tip was selected by using the MOOR FLPI2 zoom laser speckle flow real-time imaging system. The blood flow and blood flow area of tongue body were measured and recorded in four positions of tongue root and left and right sides of tongue. The statistical analysis was carried out by spss17.0 software package. To explore the similarities and differences of tongue microcirculation between patients with type 2 diabetes mellitus and patients with different complications of type 2 diabetes mellitus. Results 1. The average blood flow of tongue body in patients with two or three complications was lower than that in patients with type 2 diabetes mellitus (P 0.05). The mean blood flow area of tongue body in patients with three complications was smaller than that in patients with type 2 diabetes mellitus and patients with one complication (P 0.05) .2.The patients with peripheral neuropathy and / or arteriosclerosis were treated with peripheral neuropathy and / or arteriosclerosis. The mean blood flow of tongue body in patients with type 2 diabetes mellitus was lower than that in patients with simple type 2 diabetes mellitus (P 0.05). The mean blood flow area of tongue body in patients with peripheral neuropathy and / or arteriosclerosis was smaller than that in patients with type 2 diabetes mellitus. Body mean blood flow (P0.05). 3. Mean blood flow in tongue and uric acid in patients. There was a negative correlation between fasting C peptide (2 h postprandial) in waist circumference (P 0.05). Conclusion 1. The microcirculation disturbance of tongue was aggravated after diabetes mellitus complicated with related complications, and the severity of these complications increased with the increase of the types of complications, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, and peripheral neuropathy. Arteriosclerosis is the main complication of microcirculation disorder in type 2 diabetes mellitus. Blood stasis in TCM plays an important role in the occurrence and development of complications in type 2 diabetes mellitus. Obesity is an important risk factor of microcirculation disorder in type 2 diabetes mellitus. The degree of microcirculation disturbance in patients with diabetes increases with the increase of fasting C peptide and 2 h postprandial C peptide level.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259
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本文編號(hào)：1633225