本文選題：健心平律丸　切入點：高血壓病　出處：《廣州中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：本研究通過臨床設(shè)計,觀察健心平律丸治療高血壓病痰濕壅盛型患者治療前后同型半胱氨酸、C-反應(yīng)蛋白、尿酸水平、血壓、臨床癥狀的變化,證明健心平律丸對高血壓病痰濕壅盛型患者相關(guān)危險因素(HCY、CRP、UA)、血壓等的影響,為更好的控制血壓、防止高血壓的靶器官損害、并發(fā)癥的出現(xiàn)提供臨床新思路。方法：將符合中西醫(yī)納入標(biāo)準(zhǔn)的60例患者,按1：1比例隨機分為治療組、對照組,對照組予苯磺酸氨氯地平片5mg qd晨服,治療組在對照組基礎(chǔ)上予加健心平律丸6gtid飯后服,療程4周。在治療前后觀察患者血壓、中醫(yī)證候積分、同型半胱氨酸、C-反應(yīng)蛋白、尿酸水平的變化。結(jié)果：血壓水平：經(jīng)4周治療后,兩組收縮壓、舒張壓均下降(P0.01),治療組收縮壓、舒張壓較對照組下降明顯(P0.05),對照組降壓總效率為70%,治療組總有效率為87%,治療組降壓效果優(yōu)于對照組(P0.05),有統(tǒng)計學(xué)意義。HCY變化：對照組、治療組治療后HCY水平均下降(P0.01),治療組HCY水平明顯低于對照組(P0.05),有統(tǒng)計學(xué)意義。CRP變化：對照組、治療組治療前后CRP水平對比明顯下降(P0.01),治療后組間比較,治療組CRP水平明顯低于對照組(P0.01),有統(tǒng)計學(xué)意義。UA變化：兩組治療前后UA水平對比明顯下降(P0.01),治療后組間比較,治療組UA明顯低于對照組(P0.05),有統(tǒng)計學(xué)意義。中醫(yī)證候：對照組與治療組治療前后中醫(yī)證候積分對比明顯下降(P0.01),治療后治療組中醫(yī)證候積分明顯低于對照組(P0.01),對照組證候療效總效率為50%,治療組總有效率為87%,治療組療效優(yōu)于對照組(P0.01),有統(tǒng)計學(xué)意義。結(jié)論：1、健心平律丸可以輔助降壓藥物降低高血壓病痰濕壅盛型患者的收縮壓、舒張壓;2、健心平律丸可以改善高血壓病痰濕壅盛型患者的臨床癥狀；3、健心平律丸可以降低高血壓病痰濕壅盛型患者的HCY、CRP、UA,有效控制高血壓病的危險因素；4、健心平律丸無不良反應(yīng),可以作為高血壓病治療的安全有效藥物。
[Abstract]:Objective: to observe the changes of homocysteine C-reactive protein, uric acid level, blood pressure and clinical symptoms in patients with hypertensives with phlegm-dampness syndrome before and after treatment. It is proved that Jianxin Ping Law pills can affect the risk factors such as HCY and CRP UAU, blood pressure in patients with hypertensives with phlegm and dampness, so as to better control blood pressure and prevent the damage of target organs of hypertension. Methods: 60 patients who met the standard of traditional Chinese and western medicine were randomly divided into treatment group, control group and control group, which were treated with amlodipine benzenesulfonic acid 5mg QD in the morning. On the basis of control group, the treatment group was given 6gtid after meals with Jianxinping Pill for 4 weeks. The blood pressure, TCM syndromes score and homocysteine C-reactive protein were observed before and after treatment. Results: blood pressure: after 4 weeks treatment, systolic blood pressure and diastolic blood pressure were decreased in both groups (P 0.01), while in the treatment group, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were decreased. Compared with the control group, the diastolic blood pressure (DBP) decreased significantly (P 0.05), the total antihypertensive efficiency in the control group was 70 and the total effective rate in the treatment group was 87. The antihypertensive effect in the treatment group was better than that in the control group (P 0.05), and there were significant changes of HCY in the control group. The level of HCY in the treatment group was significantly lower than that in the control group (P 0.01), and the level of HCY in the treatment group was significantly lower than that in the control group (P 0.05). In the control group, the level of CRP in the treatment group was significantly lower than that in the control group before and after treatment (P 0.01), and there was a significant difference between the two groups after treatment. The level of CRP in the treatment group was significantly lower than that in the control group (P 0.01), and there was a significant change in UA: the levels of UA in the two groups decreased significantly before and after treatment, and there was a significant difference between the two groups after treatment. The UA in the treatment group was significantly lower than that in the control group (P 0.05N), which had statistical significance. TCM syndromes in the control group and the treatment group decreased significantly before and after treatment, and after treatment, the score of TCM syndrome in the treatment group was significantly lower than that in the control group (P 0.01), and that in the control group was significantly lower than that in the control group. The total effective rate of syndromes in the treatment group was 50 and the total effective rate in the treatment group was 87. The curative effect of the treatment group was better than that of the control group (P 0.01), which was statistically significant. Conclusion: the Jianxin Pinglu pills can help to reduce the systolic blood pressure of the patients with hypertensives with phlegm dampness and accumulation of phlegm and dampness. The clinical symptoms of the patients with hypertensives with phlegm and dampness obstruction were improved. Jianxin Pinglu pills could reduce the HCYC CRPUAA of patients with hypertensives with phlegm dampness, and effectively control the risk factors of hypertension. There was no adverse reaction in Jianxin Pinglu pills. It can be used as a safe and effective drug for the treatment of hypertension.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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