發(fā)布時間：2018-03-08 06:44

  本文選題：養(yǎng)陰清咽飲　切入點：放射性口腔干燥癥　出處：《湖南中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：研究目的:旨在觀察養(yǎng)陰清咽飲對放射性口干癥患者的臨床療效,為中醫(yī)藥防治放射性口腔干燥癥提供客觀依據(jù),進一步擴展中醫(yī)藥防治放療毒副反應的內(nèi)涵。研究方法:采用開放性隨機對照試驗研究方法,將59例病例采用隨機數(shù)字表法為2組,治療組29例,對照組30例,治療組采用養(yǎng)陰清咽飲聯(lián)合放療治療,對照組采用單純放療治療,兩組治療過程中出現(xiàn)的嚴重不良反應均采取相同對癥處理方式。比較兩組病例放療完成率、口干癥出現(xiàn)的時間及累積放射劑量、口干程度分級、唾液流量、KPS、不良反應及安全性。采用SPSS 19.0統(tǒng)計學軟件進行統(tǒng)計分析。結(jié)果:(1)本研究共納入59例患者,其中治療組29例,對照組30例,治療過程中脫落和剔除的患者總共7人,最后納入統(tǒng)計分析的患者為52例;最初對59例鼻咽癌患者的構(gòu)成分析發(fā)現(xiàn),兩組患者的性別、年齡、臨床分期、KPS評分等基本情況經(jīng)統(tǒng)計學分析,P值均0.05,即上述各方面無明顯差異,兩組具有齊同可比性。(2)口干出現(xiàn)的時間及累計放射劑量:治療組出現(xiàn)口干的時間晚于對照組,兩組相比有顯著性差異(P0.05);出現(xiàn)口干累計放射劑量兩組相比有顯著性差異(P0.05)。(3)口咽反應:口咽反應程度治療組較對照組輕,兩組比較具有顯著性差異(P0.05)。(3)唾液流速:兩組放療前后組內(nèi)比較均具有顯著性差異(P0.01),說明放療劑量越大,對唾液腺損傷越大,唾液流速越小;且放療后兩組唾液流速下降程度存在顯著性差異(P0.05)。(4)口干程度分級:放療后治療組口干程度相比對照組明顯較輕,存在顯著性差異(P0.05).(5)生活質(zhì)量方面:KPS評分在治療前后相比,兩組不具有顯著性差異(P0.05)。結(jié)論:養(yǎng)陰清咽飲可以延緩鼻咽癌患者放射性口腔干燥癥的發(fā)生時間,減輕口干程度;可減少放療副反應的發(fā)生,具有改善臨床癥狀、提高生存質(zhì)量的作用,臨床應用安全,值得推廣。
[Abstract]:Objective: to observe the clinical effect of Yangyin Qingyan decoction (YQYY) on patients with radiation dry mouth, and to provide an objective basis for the prevention and treatment of radioactive xerostomia by traditional Chinese medicine (TCM). Methods: open randomized controlled trial was used to study 59 cases in two groups, 29 cases in treatment group and 30 cases in control group, and 59 cases were randomly divided into two groups, 29 cases in treatment group, 30 cases in control group, 29 cases in treatment group, 30 cases in control group, 29 cases in treatment group and 30 cases in control group. The treatment group was treated with Yangyin Qingyan decoction combined with radiotherapy, while the control group was treated with radiotherapy alone. The severe adverse reactions in both groups were treated in the same symptomatic manner. The completion rate of radiotherapy was compared between the two groups. The time and cumulative radiation dose of xerostomia, dry mouth grade, saliva flow rate, adverse reaction and safety were analyzed by SPSS 19.0 statistical software. Results the study included 59 patients, including 29 patients in the treatment group, 29 patients in the treatment group, 29 patients in the treatment group, and 29 patients in the treatment group. In the control group, there were 7 patients who dropped out and eliminated during the treatment, and 52 patients were included in the statistical analysis. At first, the composition analysis of 59 patients with nasopharyngeal carcinoma found that the sex and age of the two groups of patients. The clinical stage and KPS score were all 0.05 by statistical analysis, that is to say, there was no significant difference between the two groups in the above aspects. The time and cumulative radiation dose of dry mouth appeared in the two groups were comparable. The time of dry mouth appeared in the treatment group was later than that in the control group. There was significant difference between the two groups (P 0.05) and the cumulative dose of dry oral radiation was significantly different between the two groups (P < 0.05). The degree of oropharynx reaction in the treatment group was less than that in the control group, and there was a significant difference in the oral and pharyngeal reaction between the two groups (P < 0.05). There was significant difference in saliva velocity between the two groups: there was significant difference between the two groups before and after radiotherapy, which indicated that the larger the dose of radiotherapy, the greater the damage to salivary gland and the smaller the velocity of saliva. There was significant difference in the decrease of salivary velocity between the two groups after radiotherapy (P0.05N. 4) dry degree of mouth: the dry degree of mouth in the treatment group after radiotherapy was significantly lighter than that in the control group, and there was significant difference in the quality of life between the two groups (P0.05. 5) the weight KPS score was compared before and after treatment, and there was a significant difference between the two groups in terms of quality of life before and after treatment. Conclusion: Yangyin Qingyan decoction can delay the occurrence time of radiation-induced xerostomia in patients with nasopharyngeal carcinoma, reduce the degree of dry mouth, reduce the incidence of side effects of radiotherapy, and improve the clinical symptoms. Improve the effect of quality of life, clinical application safety, it is worth popularizing.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R273

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