本文選題：化濁行血方　切入點：短暫性腦缺血發(fā)作　出處：《山東中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的:以Meta分析的手段為依據(jù),真實而有效的對化濁行血方減少短暫性腦缺血發(fā)作次數(shù)及其安全性進行評價,旨在能為臨床恰當而安全的選擇用藥以及中醫(yī)治未病方向提供客觀參考,期能夠增強中醫(yī)藥在現(xiàn)代醫(yī)學中應(yīng)用的優(yōu)勢。方法:對Cochrane圖書館、Pubmed、Embase、中國生物醫(yī)學文獻數(shù)據(jù)庫(CBM)、維普(VIP)、CNKI、萬方數(shù)(WF)等數(shù)據(jù)庫進行檢索,既定關(guān)鍵詞是:“隨機對照臨床試驗”、“化濁行血方”和“短暫性腦缺血發(fā)作”,納入僅應(yīng)用化濁行血方和安慰劑或其他非化濁行血方相關(guān)藥物的臨床研究,嚴格依據(jù)既定的納入以及排除標準對相關(guān)文獻篩查,嚴格遵守篩選文獻時的獨立性,客觀進行質(zhì)量評價,交叉核對提取的原始資料,同時行異質(zhì)性及敏感性分析,從而完成Meta分析。結(jié)果:共納入符合既定條件的研究有3個,皆是隨機對照臨床試驗,其具體進行地皆是中國,共含245例實驗對象,其中試驗組123例,對照組122例,都確診是短暫性腦缺血發(fā)作。所測方向中,若I250%,P0.1,則以固定效應(yīng)模型為分析方法。綜合分析結(jié)果,化濁行血方在減少短暫性腦缺血發(fā)作發(fā)作次數(shù)及促進相關(guān)血液指標趨于正常方面,明顯比西藥對照組更具優(yōu)勢,且相對安全。結(jié)論:化濁行血方治療短暫性腦缺血發(fā)作臨床療效確切,支持臨床選擇用藥。因契合既定納入要求的文獻量不多、涉及的樣本量不大、文獻質(zhì)量相對不高等因素,致使本研究存在某些程度上的局限,相關(guān)方面的研究及探索尚需更深入的充實及豐滿。
[Abstract]:Objective: to evaluate the safety of Huazhuoxingxue recipe in reducing the frequency of transient ischemic attack based on Meta analysis. The aim is to provide an objective reference for the proper and safe choice of medicine and the direction of treating the disease in traditional Chinese medicine. Methods: the Cochrane Library, China Biomedical Literature Database, China Biomedical Literature Database and other databases, such as Cochrane Library, China Biomedical Literature Database, Chinese Biomedical Literature Database, etc. The established key words were: "randomized controlled clinical trial", "Huazhuoxingxue recipe" and "transient ischemic attack", and included in the clinical study of Huazhuoxingxue prescription and placebo or other non-Huazhuoxue prescription related drugs. The relevant documents were screened strictly according to the established inclusion and exclusion criteria, the independence of the screening documents was strictly observed, the quality evaluation was carried out objectively, the raw data was cross-checked and extracted, and the heterogeneity and sensitivity analysis were carried out at the same time. Results: there were 3 randomized controlled clinical trials, all of which were conducted in China, including 123 cases in the experimental group and 122 cases in the control group. All were diagnosed as transient ischemic attacks. In the direction measured, if I 250 and P 0.1, the fixed effect model was used as the analytical method. Huazhuoxingxue recipe has more advantages than the western medicine control group in reducing the frequency of transient ischemic attack and promoting the related blood indexes to normal. Conclusion: Huazhuoxingxue prescription is effective in the treatment of transient ischemic attack and supports clinical choice of medicine. As a result, there are some limitations in this study, and the related research and exploration need to be more substantial and full.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R277.7

【參考文獻】

相關(guān)期刊論文 前10條

1 于金平;宗壽健;胡曉潔;孫海洋;柴宗穎;吳春麗;于麗紅;王興臣;;化濁行血方減少短暫性腦缺血發(fā)作次數(shù)及安全性的系統(tǒng)評價[J];中醫(yī)藥通報;2015年05期

2 俞年塘;韓為;張玲;朱玲玲;王清偉;張國慶;劉白云;;針刺預(yù)處理對卒中早期預(yù)警的研究[J];中國針灸;2013年11期

3 蔡黎;黃谷;周端;呂樺;;穴位刮痧療法防治中風療效觀察[J];臨床薈萃;2013年04期

4 宗壽健;王興臣;蔡敏;賀燕;王忠琳;;化濁行血湯治療短暫性腦缺血臨床研究[J];山東中醫(yī)雜志;2012年07期

5 齊錫友;董致郅;謝春榮;;從證型分布特點談內(nèi)風與中風先兆證的關(guān)系[J];中國中醫(yī)急癥;2012年06期

6 張磊;于學平;;針刺治療椎-基底動脈系統(tǒng)短暫性腦缺血發(fā)作性眩暈的療效觀察[J];針灸臨床雜志;2011年12期

7 楊雄杰;張波;;溫陽通脈湯治療短暫性腦缺血發(fā)作30例[J];安徽中醫(yī)學院學報;2011年05期

8 孟慶良;孟凡輝;;頭針治療短暫性腦缺血發(fā)作71例[J];上海針灸雜志;2010年11期

9 張鵬;王中琳;;化濁行血湯治療短暫性腦缺血發(fā)作60例療效觀察[J];內(nèi)蒙古中醫(yī)藥;2010年01期

10 王榮;李長生;;從中醫(yī)學對中風先兆的認識談中風病的預(yù)防[J];中西醫(yī)結(jié)合心腦血管病雜志;2009年11期

，

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