本文選題：冠心病　切入點：白介素-6　出處：《南京中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的：探討冠心病穩(wěn)定型心絞痛血清白介素-6水平與中醫(yī)證候要素痰、瘀的相關(guān)性,為冠心病中醫(yī)辨證提供更多客觀化依據(jù)。方法：臨床搜集確診為冠心病穩(wěn)定型心絞痛患者病例122例,對患者中醫(yī)證候要素積分進行統(tǒng)計,并測量患者血清白介素-6水平,通過2X2析因分析,研究血清白介素-6水平與中醫(yī)證候要素痰、瘀之間的相關(guān)性。結(jié)果：白細胞介素-6水平,在冠心病有“痰”組,明顯高于無“痰”組(P=0.00)；有“瘀”組,明顯高于無“瘀”組(P=0.00)；“痰瘀互結(jié)”組,明顯高于“非痰非瘀”組(P=0.00)；“痰瘀互結(jié)”組,明顯高于“痰濁”組(P值=0.00)；“痰瘀互結(jié)”組,明顯高于“瘀血”組(P值=0.005)；“痰濁”組,明顯高于“非痰非瘀”(P值=0.002)。白細胞介素-6水平與痰證、瘀證積分高度正相關(guān)。白細胞介素-6水平與痰證證素積分存在線性回歸關(guān)系；與瘀證證素積分存在曲線回歸關(guān)系。結(jié)論：1.冠心病患者血清白細胞介素-6水平,在痰、瘀兩個證候要素上密切相關(guān)。當痰瘀兩種證候要素兼夾存在時,白細胞介素-6的水平,于痰、瘀兩種病理因素共存情況下,明顯高于兩種病理因素皆無,或僅有一種病理因素作祟時。2.冠心病患者血清白細胞介素-6水平,在“瘀血”組,與“痰濁”組比較,兩組間不存在顯著統(tǒng)計學差異。兩者鑒別診斷方向還需要進一步研究。
[Abstract]:Objective: To investigate the stable angina pectoris of coronary heart disease serum interleukin -6 levels and TCM Syndromes of phlegm, blood stasis and correlation, provide more objective basis for TCM syndrome differentiation of coronary heart disease. Methods: to collect clinical cases diagnosed in patients with stable angina pectoris of coronary heart disease in 122 cases, statistics of syndromes elements integral, and measurement of serum interleukin -6 levels by 2X2 factorial analysis of serum interleukin -6 levels and TCM Syndromes of phlegm and blood stasis. Results: the correlation between interleukin -6 levels in coronary heart disease group was significantly higher than that of "phlegm", no "sputum" group (P=0.00); the "stasis" group, obviously no higher than the "stasis" group (P=0.00); the phlegm and blood stasis group, was significantly higher than that of non phlegm and non blood stasis group (P=0.00); the phlegm and blood stasis group, was significantly higher than that of "phlegm" group (P =0.00); the phlegm and blood stasis group was significantly higher than that of "blood stasis" ("group The value of P =0.005); "phlegm" group was significantly higher than that of "non Sputum Stasis" (P = =0.002). Interleukin -6 level and phlegm syndrome, blood stasis syndrome integral high positive correlation integral interleukin -6 level and phlegm syndrome had linear regression relation with blood stasis syndrome; there exists a integral curve regression relationship. Conclusion: 1. the serum interleukin -6 level in sputum, blood stasis two syndrome elements are closely related. When the two kinds of phlegm and blood stasis syndrome elements and clip exist, interleukin -6 level in sputum, blood stasis two kinds of pathological factors coexist situation that is obviously higher than that of two kinds of pathological factors are, or only a pathological factor.2. in serum of patients with coronary heart disease and interleukin -6 levels in blood stasis group, compared with the "phlegm" group, no significant difference existed between the two groups. Further research is needed both differential diagnosis.

【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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