本文關(guān)鍵詞： 血瘀質(zhì) 腦梗死 關(guān)聯(lián)規(guī)則 用藥規(guī)律　出處：《山東中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:采用關(guān)聯(lián)規(guī)則分析血瘀質(zhì)腦梗死恢復(fù)期患者用藥規(guī)律,為臨床預(yù)防治療提供用藥參考。方法:依照流行病學(xué)調(diào)查方法,選取山東省中醫(yī)院、煙臺市中醫(yī)醫(yī)院、蓬萊市中醫(yī)醫(yī)院等不同地域、不同級別的3家中醫(yī)院中處于恢復(fù)期的腦梗死血瘀質(zhì)患者,收集其處方用藥,運用SPSS Clementine 12.0數(shù)據(jù)挖掘軟件對該數(shù)據(jù)所含藥物進(jìn)行關(guān)聯(lián)規(guī)則挖掘研究,以獲得相互關(guān)聯(lián)的藥對,并對其進(jìn)行相關(guān)性分析。結(jié)果:本研究共獲得處方400首,中藥242味,使用頻次在25次(包括25次)以上的藥物共49種。使用頻次在前五位的藥類依次是活血化瘀藥、補虛藥、清熱藥、化痰止咳平喘藥、平肝息風(fēng)藥。共獲得規(guī)則250條,出現(xiàn)規(guī)則最多的藥物是紅花,其次是桃仁、當(dāng)歸、川芎、赤芍等。其中支持度較高的規(guī)則有:甘草+紅花→桃仁(支持度23.00%,提升為1.39%),甘草+川芎→紅花(支持度18.75%,提升為1.227%),當(dāng)歸+紅花→桃仁(支持度20.5%,提升為1.448%),當(dāng)歸+紅花→川芎(支持度20.5%,提升為1.7%),白術(shù)+紅花→桃仁(支持度18.5%,提升為1.308%),當(dāng)歸+桃仁+紅花→川芎(支持度16.25%,提升為1.758%),天竺黃→丹參(支持度17.75%,提升1.736%),竹茹→紅花(支持度15%,提升1.199%),竹茹→丹參(支持度15%,提升1.514%),赤芍+紅花→桃仁(支持度25.5%,提升度1.433),赤芍+川芎→紅花(支持度17.25%,提升度1.237%),桃仁→紅花(支持度為54.75%,提升度為1.269%),川芎+桃仁→紅花(支持度為22%,提升度為1.388%),牛膝+紅花→桃仁(支持度為15%,提升度為1.492%)等。結(jié)論:關(guān)聯(lián)規(guī)則可用于腦梗死恢復(fù)期血瘀質(zhì)藥物的配伍規(guī)律研究,活血化瘀藥與其他藥物配伍是臨床用藥關(guān)鍵。
[Abstract]:Objective: to analyze the regularity of drug use in convalescent patients with cerebral infarction with blood stasis by using association rules, and to provide reference for clinical prevention and treatment. Methods: according to the epidemiological investigation method, Shandong traditional Chinese Medicine Hospital and Yantai traditional Chinese Medicine Hospital were selected. Penglai traditional Chinese Medicine Hospital and other different regions and different levels of three Chinese medicine hospitals in the convalescent stage of cerebral infarction patients with blood stasis, collect their prescriptions, using SPSS Clementine 12.0 data mining software to the data contained in the association rules mining research. Results: in this study, 400 prescriptions with 242 Chinese herbs were obtained. There are 49 kinds of drugs that have been used more than 25 times (including 25 times). The first five drugs used frequently are blood activating drugs, tonifying drugs, heat clearing drugs, phlegm relieving cough and relieving asthma medicine, calming the liver and relieving wind medicine. A total of 250 rules have been obtained. The most common drug is safflower, followed by peach kernel, angelica sinensis, ligustraum chuanxiong, red peony etc. Among them, the rule with higher support degree is: licorice safflower. 鈫扨each kernel (supporting degree 23.00, promoted to 1.39 Rhizoma Rhizoma Chuanxiong). 鈫扴afflower (supporting degree 18.75, promoted to 1.227%), Angelica sinensis. 鈫扨each kernel (support degree 20. 5%, promoted to 1. 448%), Angelica sinensis. 鈫扲hizoma Chuanxiong (support degree 20.5g, promoted to 1.7cm, Safflower Atractylodes. 鈫扨each kernel (support degree 18. 5%, promoted to 1. 308%), Angelica sinensis red flower. 鈫扲hizoma Chuanxiong (supporting degree 16.25), promoted to 1.758 Rhizome, Tianzhu Huang. 鈫扴alvia miltiorrhiza (support degree 17.75), raise 1.736%, Bamboo Ru. 鈫扴afflower (support degree 15, lift up 1.199). 鈫扴alvia miltiorrhiza (support degree 15, promotion 1.514), red peony safflower. 鈫扨each seed (supporting degree 25.5, lifting degree 1.433), Rhizoma Chuanxiong Rhizoma Paeoniae Alba. 鈫扴afflower (support 17.25), lifting 1.237am, peach kernel. 鈫扴afflower (support is 54.75, promotion is 1.269), Ligusticum chuanxiong (Peach kernel). 鈫扴afflower (support is 22g, promotion is 1.388b), Achyranthes bidentata. 鈫扖onclusion: Association rules can be used to study the compatibility of blood stasis drugs in the convalescent period of cerebral infarction, and the compatibility of promoting blood stasis drugs with other drugs is the key to clinical use.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R277.7;TP311.13

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