本文關(guān)鍵詞： 滋陰活血方 2型糖尿病 陰虛血瘀 中醫(yī)藥治療　出處：《南京中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:使用滋陰活血方聯(lián)合西藥常規(guī)治療進行臨床觀察,與單純使用糖尿病西藥常規(guī)治療進行比較。為糖尿病治療提供更多的方案選擇。控制疾病進展,改善并發(fā)癥,提高生活質(zhì)量。.方法:對133例符合2型糖尿病(T2DM)陰虛血瘀診斷標準的患者進行臨床觀察。以滋陰活血方聯(lián)合西藥常規(guī)治療為治療組,以單純西藥常規(guī)治療為對照組。分析記錄患者治療后1個月的臨床療效:身體質(zhì)量指數(shù)(BMI)、空腹血糖(FPG)、餐后2小時血糖(2hPG)、糖化血紅蛋白(HbA1C)、總膽固醇(TC)、.甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、空腹胰島素(FINS)、餐后2小時胰島素(2hINS)、空腹C肽水平(FCP)、餐后2小時C肽(2hCP),谷丙轉(zhuǎn)氨酶(ALT),谷草轉(zhuǎn)氨酶(AST),尿微量白蛋白(mA1b),以及臨床癥候積分。結(jié)果:(1)治療后,治療組癥候總積分較對照組明顯降低(P0.05),且其總有效率高于對照組。(2)治療后,對照組的空腹血糖和餐后2小時血糖較治療前降低(P0.05)。治療組的空腹血糖、餐后2小時血糖、糖化血紅蛋白均低于治療前(P0.05);且均較對照組降低(P0.05)。治療前后兩組患者的體質(zhì)量指數(shù)未見差異(P0.05)。(3)治療后,治療組的空腹及餐后C肽和胰島素均較治療前明顯增加(P0.05),上述數(shù)據(jù)在對照組未見有效變化(P0.05)。且治療組治療后空腹及餐后胰島素水平較對照組升高明顯(P0.05)。(4)治療后,治療組的總膽固醇、甘油三酯、低密度脂蛋白均有所降低(P0.05),且總膽固醇、甘油三酯下降幅度較對照組明顯(P0.05),對照組的相關(guān)數(shù)據(jù)無明顯改變(P0.05)。兩組患者高密度脂蛋白在治療前后無統(tǒng)計學意義。(5)兩組患者治療前后谷丙轉(zhuǎn)氨酶、谷草轉(zhuǎn)氨酶及尿微量白蛋白數(shù)值均未見明顯變化(P0.05),且治療期間均未發(fā)生低血糖癥狀。結(jié)論:陰虛血瘀證型糖尿病患者聯(lián)合滋陰活血方治療,能有效改善患者臨床癥狀,降低血糖、糖化血紅蛋白,降低患者血脂,改善脂質(zhì)代謝紊亂情況,且對患者肝腎功能無明顯影響。臨床應用相對安全。
[Abstract]:Objective: to observe the clinical effects of Ziyin Huoxue recipe combined with routine western medicine, and to provide more options for diabetes treatment, to control the progress of the disease and to improve the complications, compared with the routine treatment of diabetes mellitus. Methods: 133 patients who met the diagnostic criteria of yin deficiency and blood stasis in type 2 diabetes mellitus T2DM.Methods: the treatment group was treated with Ziyin Huoxue recipe combined with routine western medicine. In the control group, routine therapy of western medicine was used as the control group. The clinical effects of 1 month after treatment were analyzed and recorded: body mass index (BMI), fasting blood glucose (FPG), 2 h postprandial blood glucose (GPG), HbA1C (glycosylated hemoglobin), total cholesterol (TC), triglyceride (TGG), low levels of triglyceride (TGG). LDLX, HDL, FINSN, 2hINSN, FCPP, 2hCPT, ALT, ASTT, urinary albumin mA1bT, and the clinical symptom score of the two hours postprandial C peptide, alanine aminotransferase (alt), aspartate aminotransferase (ASTT), urinary albumin mA1bU, and clinical symptoms. After treatment, The total symptom score of the treatment group was significantly lower than that of the control group, and the total effective rate was higher than that of the control group.) after treatment, the fasting blood glucose and 2 hours postprandial blood glucose in the control group were lower than those before treatment. The fasting blood glucose and 2 hours postprandial blood glucose in the treatment group were lower than those before treatment. The levels of glycosylated hemoglobin were lower than those of the control group before and after treatment. There was no difference in body mass index (BMI) between the two groups before and after treatment. The fasting and postprandial C peptide and insulin levels in the treatment group were significantly higher than those before treatment. The above data had no significant change in the control group. The fasting and postprandial insulin levels in the treatment group were significantly higher than those in the control group. The total cholesterol, triglyceride and low density lipoprotein in the treatment group were all decreased, and the total cholesterol, The decrease of triglyceride was significantly higher than that of the control group (P 0.05), and there was no significant change in the data of the control group. There was no significant difference in serum alanine aminotransferase between the two groups before and after treatment. Glutamic oxaloacetic transaminase and urinary microalbumin were not significantly changed, and no hypoglycemia symptoms occurred during the treatment. Conclusion: the combination of Ziyin Huoxue recipe for diabetes with yin deficiency and blood stasis syndrome can effectively improve the clinical symptoms of the patients. Lowering blood sugar, glycosylated hemoglobin, lowering blood lipid, improving the disorder of lipid metabolism, and has no obvious effect on the liver and kidney function of patients, clinical application is relatively safe.
【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R259

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本文編號：1501775