本文關鍵詞： 柴芍三白湯 反流性食管炎 肝胃不和證 臨床療效觀察　出處：《湖南中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的:觀察柴芍三白湯治療反流性食管炎肝胃不和證患者臨床療效及安全性。方法:選取2015年2月至2016年1月湖南中醫(yī)藥大學第一附屬醫(yī)院消化內科門診招募,符合反流性食管炎肝胃不和證診斷標準的患者60例,分為治療組30例,對照組30例,治療組給予柴芍三白湯,對照組給予雷貝拉唑聯(lián)合莫沙必利,兩組療程均為8周,治療結束后對疾病療效、中醫(yī)證候總積分變化、胃鏡下食管黏膜分級計分、不良反應等方面進行比較統(tǒng)計分析。結果:(1)柴芍三白湯組臨床療效總有效率90%;雷貝拉唑聯(lián)合莫沙比利組總有效率76.67%,兩組總有效率比較差異有統(tǒng)計學意義(p0.05)。(2)中醫(yī)證候總積分變化,兩組治療前與治療后比較差異有統(tǒng)計學意義(p0.05),治療后中藥組與西藥組比較差異具有統(tǒng)計學意義(P0.05)。在改善主癥反酸、燒心方面,中藥組和西藥組比較,差異無統(tǒng)計學意義(p0.05),在改善主癥胸骨后疼痛方面,兩組比較差異有統(tǒng)計學意義(p0.05),中藥組療效優(yōu)于西藥組;在改善次癥納差方面,兩組比較無統(tǒng)計學意義(p0.05),在改善次癥噯氣呃逆、喜太息、脘腹脹滿或脹痛方面,兩組比較差異有統(tǒng)計學意義(p0.05),中藥組療效優(yōu)于西藥組。(3)胃鏡下食管黏膜分級記分比較,中藥組和西藥組治療后比較差異具有顯著統(tǒng)計學意義(p0.01)。(4)不良反應觀察,中藥組治療期間未出現明顯不良反應及毒副作用,西藥組出現惡心2例,未經處理,自然消失。結論:柴芍三白湯治療反流性食管炎肝胃不和證患者療效肯定,能有效緩解臨床癥狀,改善胃鏡下食管黏膜病變情況,且安全性良好無副作用,值得臨床推廣。
[Abstract]:Objective: to observe the clinical efficacy and safety of Chaixiaoshanbai decoction in the treatment of reflux esophagitis with liver-stomach disharmony syndrome. From February 2015 to January 2016, the first affiliated Hospital of Hunan University of traditional Chinese Medicine was recruited from the Department of Digestive Medicine. Sixty patients with reflux esophagitis were divided into treatment group (n = 30) and control group (n = 30). The course of treatment in both groups was 8 weeks. After the treatment, the curative effect, the total integral change of TCM syndromes and the score of esophageal mucosal grading under gastroscopy were observed. The adverse reactions were compared and analyzed. Results the total effective rate was 90 in the Chaixiaoshanbai decoction group. The total effective rate of rabeprazole combined with mosapride group was 76.67. The difference of total effective rate between the two groups was statistically significant. The difference between the two groups before and after treatment was statistically significant (P 0.05), and the difference between the Chinese medicine group and the western medicine group was statistically significant (P 0.05). There was no significant difference between the Chinese medicine group and the western medicine group, but there was no significant difference between the two groups in improving the pain after sternum of the main symptom. The curative effect of the traditional Chinese medicine group was better than that of the western medicine group. There was no significant difference between the two groups in improving the anorexia of the secondary symptoms. The two groups had no statistical significance in improving the belching hiccup in the secondary syndrome, and in the improvement of belching hiccup, too much information, abdominal distension or distending pain. The difference between the two groups was statistically significant (P 0.05). The curative effect of the traditional Chinese medicine group was better than that of the western medicine group. 3) the score of esophageal mucosal grading under gastroscopy was better than that in the traditional Chinese medicine group. There was significant difference between the Chinese medicine group and the western medicine group after treatment. There was a significant difference between the two groups in the observation of adverse reactions. There were no obvious adverse reactions and side effects during the treatment period in the Chinese medicine group. Western medicine group of 2 cases of nausea, untreated, natural disappearance. Conclusion: Chaixiaoshanbai decoction treatment of reflux esophagitis liver and stomach disharmony syndrome, the curative effect is certain, can effectively alleviate the clinical symptoms. To improve the esophageal mucosal lesion under gastroscopy, and the safety is good, no side effect, worthy of clinical promotion.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

【相似文獻】

相關期刊論文 前10條

1 馬靜;;三白湯 讓你由內而外白起來[J];健康博覽;2009年06期

2 王開新,王修榮;三白湯治療小兒肺炎120例[J];光明中醫(yī);2001年02期

3 張廣武;;三白湯方治療慢性非特異性潰瘍性結腸炎[J];湖北中醫(yī)雜志;2010年12期

4 朱初良;謝勝;;“黃芪三白湯”治療十二指腸球部潰瘍100例臨床研究[J];江蘇中醫(yī)藥;2011年07期

5 ;“三白湯”加減治療“頭痛”35例分析[J];陜西中醫(yī)函授;1987年04期

6 喬世舉;吳慶寬;;自擬龍牡三白湯治療胃潰瘍20例[J];實用中醫(yī)內科雜志;1991年03期

7 祝春香,孫振蘭;三白湯加減治療頭痛35例[J];吉林中醫(yī)藥;1999年04期

8 王德玉;;徐氏三白湯臨床運用舉隅[J];浙江中醫(yī)雜志;2006年01期

9 朱國城;;二半三白湯治療肝膿瘍[J];遼寧中醫(yī)雜志;1980年01期

10 趙澤華;沙參三白湯治療小兒肺結核[J];四川中醫(yī);1991年01期

相關重要報紙文章 前2條

1 朱小平;馬敘倫與“三白湯”[N];人民日報海外版;2003年

2 劉華;三白湯讓你白又嫩[N];衛(wèi)生與生活報;2007年

相關碩士學位論文 前1條

1 劉寒嬰;柴芍三白湯治療反流性食管炎肝胃不和證的臨床療效觀察[D];湖南中醫(yī)藥大學;2016年

，

本文編號：1487465