本文關(guān)鍵詞： 清肺瀉肝湯 2型糖尿病 高脂血癥　出處：《延邊大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探究朝醫(yī)方《清肺瀉肝湯》不同劑量對(duì)高熱量飲食聯(lián)合鏈脲佐菌素誘導(dǎo)的2型糖尿病大鼠的總膽固醇、甘油三酯、低密度脂蛋白,高密度脂蛋白和空腹血糖的影響。方法：雄性SD大鼠60只,使用隨機(jī)法將10只大鼠分為正常組,喂以正常飼料,其余大鼠喂以高脂高糖飲食1周后,使用鏈脲佐菌素腹腔注射制作2型糖尿病模型,將糖尿病大鼠隨機(jī)分為模型組,陽性對(duì)照組,清肺瀉肝湯高、中、低劑量組,期間繼續(xù)喂以高脂高糖飼料,之后進(jìn)行灌胃,正常組和模型組每天用蒸餾水灌胃,對(duì)照組使用阿托伐他汀灌胃,灌胃三周后,斷頭取血處死全部大鼠,測量大鼠的空腹血糖,血清中總膽固醇、低密度脂蛋白、高密度脂蛋白和甘油三酯的含量。結(jié)果使用spss 16軟件分析,采用單因素方差分析。結(jié)果：成功建立2型糖尿病大鼠模型,經(jīng)過21天灌胃治療后,清肺瀉肝湯低、中、高劑量組空腹血糖、低密度脂蛋白膽固醇、總膽固醇、甘油三酯較模型組小,具有統(tǒng)計(jì)學(xué)意義,P0.05,與阿托伐他汀組無差異,P0.05,阿托伐他汀組和清肺瀉肝湯低、中、高劑量組高密度脂蛋白膽固醇數(shù)值較模型組高,且兩者之間無差異。結(jié)論：長期高脂高糖飼料引發(fā)肥胖容易引發(fā)糖尿病,《清肺瀉肝湯》能夠有效降低高脂高糖飼料聯(lián)合藥物誘導(dǎo)2型糖尿病大鼠的空腹血糖、甘油三酯、總膽固醇、低密度脂蛋白膽固醇,提升高密度脂蛋白膽固醇。
[Abstract]:Objective: to explore the effects of Qingfei Xiegan decoction (QFXD) on total cholesterol, triglyceride and low density lipoprotein (LDL) in type 2 diabetic rats induced by high calorie diet and streptozotocin (STZ). Methods: sixty male Sprague-Dawley rats were randomly divided into normal group and the other rats were fed with high fat and high sugar diet for 1 week. Type 2 diabetic model was made by intraperitoneal injection of streptozotocin. Diabetic rats were randomly divided into two groups: model group, positive control group, high, middle and low doses of Qingfei Xiegan decoction. The normal group and the model group were fed with distilled water every day, and the control group was fed with Atto vastatin. After three weeks of gavage, all the rats were killed by severed blood, and fasting blood glucose, serum total cholesterol and low density lipoprotein were measured. Results: the content of high density lipoprotein and triglyceride was analyzed by spss 16 software and single factor analysis of variance. Results: the rat model of type 2 diabetes was established successfully. After 21 days of oral administration, Qingfei Xiegan decoction was low and moderate. The fasting blood glucose, low density lipoprotein cholesterol, total cholesterol and triglyceride in the high dose group were smaller than those in the model group (P 0.05, P 0.05, P 0.05, Atto vastatin and Qingfei Xiegan decoction, respectively). The value of HDL-C in high dose group was higher than that in model group. Conclusion: obesity caused by long-term high fat and high sugar diet may lead to diabetes mellitus. Qingfei Xiegan decoction can effectively reduce fasting blood glucose and triglyceride in type 2 diabetic rats induced by high fat and high glucose diet combined with drugs. Total cholesterol, low density lipoprotein cholesterol, improve high density lipoprotein cholesterol.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R29

【相似文獻(xiàn)】

相關(guān)期刊論文 前8條

1 孫鋼;清肺瀉肝法在小兒肺炎支原體肺炎序貫療法中的作用[J];中國中醫(yī)急癥;2004年03期

2 王興福;張鐵峰;崔美月;;清肺瀉肝法治療胃食管反流誘發(fā)哮喘病初探[J];山東中醫(yī)雜志;2013年01期

3 金京麗;;朝醫(yī)清肺瀉肝湯治療太陰人高脂血癥1例[J];中國民族民間醫(yī)藥;2014年02期

4 朱哲;許蘭;崔雪玉;樸東振;;朝醫(yī)清肺瀉肝湯對(duì)急性期中風(fēng)病人的臨床效應(yīng)[J];中國民族醫(yī)藥雜志;2013年06期

5 張式年,李榮華;自擬清肺瀉肝湯治療鼻衄26例[J];吉林中醫(yī)藥;1997年06期

6 崔海月;崔京男;;朝醫(yī)方清肺瀉肝湯對(duì)糖尿病大鼠血糖及血脂水平影響的量-時(shí)-效關(guān)系[J];延邊大學(xué)醫(yī)學(xué)學(xué)報(bào);2012年04期

7 張德新;;夜咳治法舉隅——附驗(yàn)案3則[J];江蘇中醫(yī)藥;2009年07期

8 ;[J];;年期

相關(guān)碩士學(xué)位論文 前1條

1 崔榮根;朝藥方太陰人清肺瀉肝湯干預(yù)2型糖尿病高脂血癥的實(shí)驗(yàn)研究[D];延邊大學(xué);2016年

，

本文編號(hào)：1482258