發(fā)布時間：2018-01-21 02:08

  本文關(guān)鍵詞： 慢性肺源性心臟病 痰熱壅肺證 清金化痰湯　出處：《廣西中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:觀察在西醫(yī)常規(guī)治療基礎(chǔ)上加用清金化痰顆粒治療痰熱壅肺型肺源性心臟病患者的療效,為清金化痰顆粒治療痰熱壅肺型慢性肺源性心臟病提供依據(jù)。方法:觀察病例均來自時間為2015年1月至2016年1月廣西中醫(yī)藥大學(xué)第一附屬醫(yī)院肺病科痰熱壅肺型慢性肺源性心臟病住院患者64例,將64例患者隨機(jī)分為對照組和治療組,兩組均給予西醫(yī)常規(guī)治療,治療組加用清金化痰湯顆粒劑,觀察兩組治療前后癥狀、體征、肺動脈平均壓、心輸出量、血常規(guī)、血?dú)夥治�、凝血功能、血液流變學(xué)和腦鈉肽(brain natriuretic peptide,BNP)等變化以及治療后的有效率,并統(tǒng)計(jì)分析兩組之間的差別。結(jié)果:(1)經(jīng)統(tǒng)計(jì)分析,治療組總有效率為87.50%;對照組總有效率為71.88%;治療組的臨床療效優(yōu)于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(2)在癥狀和體征方面,治療組的癥狀總積分和體征總積分低于對照組,治療組改善癥狀和體征方面優(yōu)于對照組(P0.05)。(3)在肺動脈平均壓方面,治療組的肺動脈平均壓低于對照組,但治療組改善肺動脈平均壓優(yōu)于對照組(P0.05)。(4)在心輸出量方面,治療組的心輸出量高于對照組,治療組改善心輸出量優(yōu)于對照組(P0.05)。(5)在白細(xì)胞方面,治療組的白細(xì)胞和中性粒細(xì)胞百分比低于對照組,治療組改善白細(xì)胞方面優(yōu)于對照組(P0.05)。(6)治療組的動脈血二氧化碳分壓(partial pres-sure of carbon dioxide in artery,PaCO2)、血氧分壓(partial pressure of oxygen,PaO2)和動脈血氧飽和度(arterial oxygen saturation,SaO2)與對照組相比,治療組改善優(yōu)于對照組(P0.05)。(7)在凝血功能方面,治療組的凝血酶原時間、活化部分凝血活酶時間和凝血酶時間與對照組相比,治療組改善凝血優(yōu)于對照組(P0.05)。(8)在血液流變學(xué)方面,治療組的全血高切粘度、全血低切粘度、血漿粘度、紅細(xì)胞聚集指數(shù)與對照組相比,治療組改善血液流變學(xué)方面優(yōu)于對照組(P0.05)。(9)在BNP檢測方面,治療組的BNP與對照組相比,治療組改善心功能方面優(yōu)于對照組(P0.05)。結(jié)論:清金化痰顆粒結(jié)合西藥治療能提高痰熱壅肺型慢性肺源性心臟病患者治療療效,改善患者癥狀、體征。清金化痰顆粒可以作為痰熱壅肺型慢性肺源性心臟病的重要的輔助治療方法。
[Abstract]:Objective: to observe the curative effect of Qingjin Huatan granule (QJHuatan) on the treatment of pulmonary pulmonary heart disease with phlegm and heat obstruction on the basis of routine western medicine treatment. To provide the basis for Qingjin Huatan granule in treating chronic pulmonary heart disease with phlegm and heat obstruction. Methods:. From January 2015 to January 2016, 64 cases of chronic pulmonary heart disease with chronic pulmonary heart disease with phlegm-heat obstruction in the Department of Pulmonary Diseases, first affiliated Hospital of Guangxi University of traditional Chinese Medicine were observed. 64 patients were randomly divided into control group and treatment group, both groups were treated with routine western medicine, the treatment group was treated with Qingjinhuatan decoction granule, the symptoms, signs, mean pulmonary artery pressure, cardiac output were observed before and after treatment. The changes of blood routine, blood gas analysis, coagulation function, hemorheology, brain natriuretic peptide (BNP), and the effective rate after treatment were observed. The results showed that the total effective rate of the treatment group was 87.50; The total effective rate of the control group was 71.88; The clinical curative effect of the treatment group was better than that of the control group, the difference was statistically significant (P 0.05. 05. 2) in terms of symptoms and signs, the total score of symptoms and signs in the treatment group was lower than that in the control group. The improvement of symptoms and signs in the treatment group was better than that in the control group (P0.05. 3) the mean pulmonary artery pressure in the treatment group was lower than that in the control group. But the improvement of the mean pulmonary artery pressure in the treatment group was better than that in the control group (P 0.05). The cardiac output in the treatment group was higher than that in the control group. The percentage of leukocytes and neutrophils in the treatment group was lower than that in the control group. The improvement of leukocyte in the treatment group was better than that in the control group (P0.05. 0. 0. 6) the partial pressure of arterial blood carbon dioxide in the treatment group (. Partial pres-sure of carbon dioxide in artery. PaCO2, partial pressure of oxygen. PaO2) and arterial oxygen saturation (Pao 2) and arterial oxygen saturation (SaO2) were compared with those in the control group. Compared with the control group, the prothrombin time, activated partial thromboplastin time and thrombin time in the treatment group were better than those in the control group. In hemorheology, the whole blood viscosity, low shear viscosity, plasma viscosity and erythrocyte aggregation index of the treatment group were higher than those of the control group. The improvement of hemorheology in the treatment group was better than that in the control group (P0.05. 9) in BNP detection, the BNP in the treatment group was compared with the control group. Conclusion: Qingjin Huatan granule combined with western medicine can improve the therapeutic effect of phlegm-heat blockage pulmonary chronic pulmonary heart disease patients and improve the symptoms of patients. Physical signs. Qingjin Huatan granule can be used as an important adjuvant therapy for chronic pulmonary heart disease with phlegm and heat obstruction.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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