發(fā)布時(shí)間：2018-01-16 15:34

  本文關(guān)鍵詞：杞黃顆粒對(duì)肝腎陰虛型年齡相關(guān)性黃斑變性視力及眼底情況的影響　出處：《遼寧中醫(yī)雜志》2017年02期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 杞黃顆粒 年齡相關(guān)性黃斑變性 視力 眼底情況

【摘要】：目的:探討杞黃顆粒對(duì)年齡相關(guān)性黃斑變性(AMD)患者視力及眼底情況,如色素上皮脫失情況、玻璃膜疣、新生血管及出血量的影響。方法:采用隨機(jī)平行對(duì)照研究,將2010年6月—2014年6月在廣東省中醫(yī)院眼科及天津中醫(yī)藥大學(xué)第一附屬醫(yī)院眼科就診的肝腎陰虛型年齡相關(guān)性黃斑變性患者隨機(jī)分為實(shí)驗(yàn)組及對(duì)照組。最終入組120例患者,治療組62例,予以杞黃顆粒口服;對(duì)照組58例,予以維生素C口服。治療前后均對(duì)患者雙眼視力及眼底情況進(jìn)行記錄,經(jīng)過(guò)14周服藥后,采用t檢驗(yàn)和卡方檢驗(yàn)對(duì)數(shù)據(jù)進(jìn)行組間及組內(nèi)的對(duì)比。結(jié)果:治療前后兩組組間患者總體視力差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療前后兩組組內(nèi)對(duì)比有差異(P0.05);干性AMD治療前后視力的組間比較,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05),干性AMD治療前后視力的組內(nèi)比較,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05);濕性AMD治療前后視力的組間比較,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05),濕性AMD治療前后視力的組內(nèi)比較,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05);干性AMD患者的眼底色素上皮及玻璃膜疣治療前,組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療后兩組組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療前后兩組組內(nèi)對(duì)比,差異有統(tǒng)計(jì)學(xué)意義(P0.05);濕性AMD患者的的眼底出血及新生血管治療前后,組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療前后兩組組內(nèi)對(duì)比,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:杞黃顆粒和維生素C對(duì)肝腎陰虛型年齡相關(guān)性黃斑變性的總體視力均有改善作用,且兩者療效相當(dāng);杞黃顆粒和維生素C對(duì)于干性AMD或濕性AMD患者的視力均有一定的改善作用;杞黃顆粒和維生素C均可改善干性AMD及濕性AMD患者的眼底情況,對(duì)于干性AMD患者眼底色素上皮及玻璃膜疣改善情況,兩者療效有差異,對(duì)于濕性AMD患者眼底出血及新生血管眼底改善情況,兩者療效相當(dāng);對(duì)于個(gè)別指標(biāo)治療前組間對(duì)比存在差異,考慮因患者個(gè)體差異所致,仍符合隨機(jī)分組原則,對(duì)實(shí)驗(yàn)結(jié)果無(wú)影響。
[Abstract]:Objective: To investigate the effect of Qihuang Granule on age-related macular degeneration (AMD) patients with visual acuity and eye fundus, such as pigment epithelial loss, drusen, effects of neovascularization and hemorrhage. Methods: a randomized controlled study, June 2010 - June 2014 in Guangdong Province Traditional Chinese Medical Hospital and First Hospital Affiliated to Tianjin Medical University for treatment of liver and kidney yin deficiency age-related macular degeneration patients were randomly divided into experimental group and control group. 120 patients were enrolled, 62 cases in the treatment group were given oral Qihuang granule; 58 cases in the control group, given vitamin C orally. Before and after treatment in patients with binocular vision and fundus were recorded after 14 weeks after treatment, by t test and chi square test were compared between groups and within groups of data. Results: there was no significant difference between the two groups before and after treatment in patients with overall visual acuity differences (P0.05) before and after treatment, two Group comparison difference (P0.05) before and after AMD treatment; dry eye group comparison, the differences were statistically significant (P0.05) before and after AMD treatment, dry vision within the groups, the differences were statistically significant (P0.05); AMD group before and after treatment of visual wet between comparison, the differences were statistically meaning (P0.05), compared with AMD group before and after treatment of visual wet, the differences were statistically significant (P0.05); retinal pigment epithelium and drusen treatment of dry AMD patients, there was no significant difference between groups (P0.05), after treatment between the two groups was statistically significant (P0.05), before and after treatment in the two groups compared, the difference was statistically significant (P0.05); before and after wet AMD patients of retinal hemorrhage and neovascular treatment, there was no significant difference between groups (P0.05), comparing the two groups before and after treatment, the difference was statistically significant (P0.05 ). Conclusion: to improve the overall visual acuity of Qihuang granule and vitamin C on liver and kidney yin deficiency type of age-related macular degeneration, and the effects are nearly the same; Qihuang granule and vitamin C in patients with dry or wet AMD AMD visual acuity improved; Qihuang granule and vitamin C can improve the condition of dry eye AMD and wet AMD patients, AMD patients with retinal pigment epithelium for dry and drusen improvement, there are differences in efficacy for patients with wet AMD fundus hemorrhage and fundus neovascular improvement, two considerable effect on these differences; comparison between groups on individual indicators before treatment, due to considering the differences between patients. Is still in accordance with the principle of randomization, had no effect on the experimental results.

【作者單位】： 天津中醫(yī)藥大學(xué);天津中醫(yī)藥大學(xué)第一附屬醫(yī)院;廣州中醫(yī)藥大學(xué)第二附屬醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金面上項(xiàng)目(81173308)
【分類(lèi)號(hào)】：R276.7
【正文快照】： 老年性黃斑變性又稱年齡相關(guān)的黃斑變性(age-relatedmaeulardegeneration,AMD),是以累及視網(wǎng)膜色素上皮(RPE)、感光細(xì)胞層和脈絡(luò)膜多層組織為主的一種嚴(yán)重致盲性眼病。在美國(guó)僅1995年就有170萬(wàn)患者,其中10萬(wàn)人因此致盲。Framingham眼病研究中表明,在美國(guó)65~74歲的人群中,AMD發(fā)，

本文編號(hào)：1433735