本文關鍵詞：健脾溫陽攝血法治療紫癜病的臨床觀察　出處：《黑龍江中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

  更多相關文章： 紫癜病 健脾溫陽攝血法 CD4~+CD25~+Treg

【摘要】：目的：通過觀察健脾溫陽攝血法治療前后紫癜病(脾陽虛)患者療效及外周血CD4+CD25+Treg細胞的變化規(guī)律,探討CD4+CD25+Treg細胞在紫癜病發(fā)病中的意義,進一步研究紫癜病(脾陽虛)的免疫發(fā)病機制以及健脾溫陽攝血法治療紫癜病(脾陽虛)的機理。方法：1.觀察30例紫癜病(脾陽虛)患者接受健脾溫陽攝血法治療前后的癥狀積分。2.觀察紫癜病(脾陽虛)接受健脾溫陽攝血法治療前后外周血血小板數變化。3.采用流式細胞儀檢測紫癜病(脾陽虛)接受健脾溫陽攝血法治療前后外周血CD4+CD25+Treg細胞水平變化。結果：1.接受健脾溫陽攝血法治療后的紫癜病(脾陽虛)患者的臨床癥狀有明顯好轉,癥狀積分比接受治療前明顯降低(P0.05)；2.30例接受健脾溫陽攝血法治療后的紫癜病(脾陽虛)患者中醫(yī)癥候有效率為86.67%,臨床有效率為76.67%；3.接受健脾溫陽攝血法治療后的紫癜病(脾陽虛)患者外周血像有明顯的好轉,其中血小板數上升明顯(P0.05)；4.試驗組治療前紫癜病(脾陽虛)患者外周血CD4+CD25+Treg細胞水平較正常對照組低(P0.05),試驗組治療后紫癜病(脾陽虛)患者外周血CD4+CD25+Treg細胞水平較治療前高(P0.05),試驗組治療后紫癜病(脾陽虛)患者外周血CD4+CD25+Treg細胞水平較正常對照組低(P0.05)。結論：1.健脾溫陽攝血法治療紫癜病療效確切,能明顯改善紫癜病(脾陽虛)患者的外周血象以及臨床癥狀；2.健脾溫陽攝血法可以提高紫癜病(脾陽虛)患者CD4+CD25+Treg的表達水平。
[Abstract]:Objective: to observe the curative effect and the changes of CD4 CD25 Treg cells in peripheral blood of patients with purpura disease (deficiency of spleen yang) before and after treatment with invigorating spleen and warming yang and absorbing blood. To investigate the significance of CD4 CD25 Treg cells in the pathogenesis of purpura. To further study the immune pathogenesis of purpura disease (deficiency of spleen yang) and the mechanism of invigorating spleen and warming yang and absorbing blood to treat purpura disease (deficiency of spleen yang). Methods 1. Observe 30 cases of purpura disease (deficiency of spleen yang). Symptom score of patients before and after treatment. Observation of purpura disease (deficiency of spleen yang). Changes of platelet count in peripheral blood before and after treatment with invigorating spleen and warming yang and absorbing blood. 3. Flow cytometry was used to detect purpura disease (deficiency of spleen yang). The changes of CD4 CD25 Treg cells in peripheral blood before and after the therapy of invigorating spleen and warming yang and absorbing blood. Results: 1. Purpura disease (deficiency of spleen yang) after the therapy of tonifying spleen and warming yang and absorbing blood. The clinical symptoms of the patients improved obviously. The symptom score was significantly lower than that before treatment (P 0.05). The effective rate of TCM symptom and clinical effective rate of 2.30 cases with purpura disease (deficiency of spleen yang) were 86.67 and 76.67 respectively. 3. The peripheral blood image of the patients with purpura disease (deficiency of spleen yang) after the therapy of invigorating spleen and warming yang and absorbing blood was obviously improved, in which the platelet count increased obviously (P 0.05); 4. The level of CD4 CD25 Treg cells in peripheral blood of patients with purpura purpura (deficiency of spleen yang) was lower than that of normal control group (P0.05). The level of CD4 CD25 Treg cells in peripheral blood of patients with purpura purpura (deficiency of spleen yang) after treatment was higher than that before treatment (P 0.05). The level of CD4 CD25 Treg cells in peripheral blood of patients with purpura purpura after treatment was lower than that of control group (P 0.05). Conclusion 1.The curative effect of tonifying spleen and warming yang and absorbing blood in treating purpura disease is definite. It can obviously improve the peripheral blood and clinical symptoms of patients with purpura disease (deficiency of spleen yang). 2. The method of invigorating spleen and warming yang and absorbing blood can improve the expression of CD4 CD25 Treg in patients with purpura purpura disease (deficiency of spleen yang).
【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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