本文關(guān)鍵詞：藿鉤退熱散直腸滴注治療小兒外感發(fā)熱（外寒內(nèi)熱證）的臨床觀察　出處：《湖南中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 小兒外感發(fā)熱 外寒內(nèi)熱證 藿鉤退熱散 直腸滴注

【摘要】：目的:觀察藿鉤退熱散直腸給藥治療小兒外感發(fā)熱(外寒內(nèi)熱證)的臨床療效和安全性,并對(duì)其作用機(jī)制做進(jìn)一步的探討。方法:將滿足診斷標(biāo)準(zhǔn)的患兒共60例,按隨機(jī)原則分為兩組,其中治療組(藿鉤退熱散直腸滴注組)30例,對(duì)照組(藿鉤退熱散口服給藥組)30例。治療3天后,對(duì)兩組患兒在臨床總療效、中醫(yī)證候積分改善、起效時(shí)間、發(fā)熱終止時(shí)間等進(jìn)行比較。結(jié)果:1.以藿鉤退熱散直腸滴注的方法治療小兒外感發(fā)熱(外寒內(nèi)熱證)治療組臨床療效總有效率為100.0%,治療組治愈率為73.33%;對(duì)照組臨床總有效率為100.00%,對(duì)照組治愈率為76.67%。經(jīng)統(tǒng)計(jì)學(xué)分析,兩組臨床療效無(wú)明顯差別(P㧐0.05)。2.在中醫(yī)證候改善上,治療組治療前主癥積分值為9.70±2.64,治療后為0.60±1.07,對(duì)照組治療前主癥積分值為8.93±2.77,治療后為0.47±1.01,兩組主癥積分值治療前后比較均有統(tǒng)計(jì)學(xué)差異(P㩳0.01),兩組之間治療前后主癥積分值比較均無(wú)統(tǒng)計(jì)學(xué)差異(P㧐0.05),兩組治療方法對(duì)于中醫(yī)主癥證候積分的改善情況相同。治療組治療前總積分值為17.60±4.68,治療后為1.20±2.22,對(duì)照組治療前總積分值為17.50±4.27,治療后為0.67±1.12,兩組總積分值治療前后比較均有顯著統(tǒng)計(jì)學(xué)差異(P㩳0.01),兩組之間治療后總積分值比較無(wú)明顯統(tǒng)計(jì)學(xué)差異(P㧐0.05),兩組治療方法對(duì)于中醫(yī)證候總積分的改善情況相同。3.在起效時(shí)間上,治療組平均時(shí)間為(2.23±1.17)小時(shí),對(duì)照組為(3.47±1.55)小時(shí),兩組在起效時(shí)間上經(jīng)統(tǒng)計(jì)學(xué)檢驗(yàn)P0.05,說(shuō)明兩組退熱起效時(shí)間差異具有統(tǒng)計(jì)學(xué)意義,且治療組優(yōu)于對(duì)照組。4.在痊愈患兒的發(fā)熱完全停止時(shí)間上,治療組為(50.87±12.78)小時(shí),對(duì)照組為(51.60±16.45)小時(shí),兩組發(fā)熱停止時(shí)間經(jīng)統(tǒng)計(jì)學(xué)分析P㧐0.05,二者比較無(wú)明顯差異,說(shuō)明兩種治療方式療程相同。結(jié)論:藿鉤退熱散直腸滴注法治療小兒外感發(fā)熱(外寒內(nèi)熱證)療效與藿鉤退熱散口服給藥法無(wú)明顯差異,但患兒對(duì)直腸滴注法的接受度較口服法高。
[Abstract]:Objective: to observe the clinical efficacy and safety of Huoku antipyretic powder rectal administration in the treatment of children with exogenous fever (external cold and internal heat syndrome). Methods: 60 cases of children who met the diagnostic criteria were divided into two groups according to the random principle, including 30 cases in the treatment group (Huohook antipyretic powder rectal drip group). Control group (Huoku antipyretic powder oral administration group of 30 cases. After 3 days of treatment, the two groups of children in the clinical efficacy, TCM syndromes integral improvement, effective time. Results 1. The total effective rate was 100.0% in the treatment group of children with exogenous fever (external cold and internal heat syndrome) by rectal drip of Huohook antipyretic powder. The cure rate of treatment group was 73.33. The total effective rate in the control group was 100.00g and the cure rate in the control group was 76.67.The statistical analysis showed that there was no significant difference in the clinical efficacy between the two groups. In the improvement of TCM syndromes, the integral value of main symptoms in the treatment group was 9.70 鹵2.64 before treatment and 0.60 鹵1.07 after treatment. The score of main symptom in control group was 8.93 鹵2.77 before treatment and 0.47 鹵1.01after treatment. There was statistical difference between the two groups before and after treatment. There was no significant difference in the scores of main symptoms between the two groups before and after treatment. The total integral value of treatment group was 17.60 鹵4.68 before treatment and 1.20 鹵2.22 after treatment. The total integral value of control group was 17.50 鹵4.27 before treatment and 0.67 鹵1.12 after treatment. There was no significant difference in the total integral value between the two groups after treatment. The improvement of the total integral of TCM syndromes was the same between the two groups. The average time of the treatment group was 2.23 鹵1.17 hours. The control group was 3.47 鹵1.55 hours, the two groups in the effective time by statistical test (P0.05), indicating that the two groups of antipyretic onset time difference was statistically significant. And the treatment group was superior to the control group. 4. The time of complete cessation of fever in the cured children was 50.87 鹵12.78 hours in the treatment group and 51.60 鹵16.45 hours in the control group. The stopping time of fever in the two groups was statistically analyzed (P? There was no significant difference between the two groups. Conclusion: there is no significant difference between the two methods in the treatment of children's external fever (external cold and internal heat syndrome) and oral administration of Huoku antipyretic powder. However, the acceptance of rectal drip was higher in children than in oral.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R272

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