本文關(guān)鍵詞：藏藥莪達(dá)夏提取物水部位化學(xué)成分及其大鼠血漿移行成分的質(zhì)譜分析　出處：《基因組學(xué)與應(yīng)用生物學(xué)》2017年05期 　論文類型：期刊論文

  更多相關(guān)文章： 藏藥莪達(dá)夏 HPLC-MS 化學(xué)成分 入血成分

【摘要】：本研究運(yùn)用LC-MS技術(shù)分析藏藥莪達(dá)夏水部位體外化學(xué)成分、給藥后大鼠血漿和肝微粒體中的移行成分。采用Diamondsil C18色譜柱梯度洗脫進(jìn)行分離,負(fù)離子模式下采集譜圖。通過(guò)文獻(xiàn)比對(duì),綜合分析總離子流圖等信息,對(duì)莪達(dá)夏水部位的化學(xué)成分及其體內(nèi)移行成分進(jìn)行定性研究。共推斷出莪達(dá)夏水部位中40個(gè)化學(xué)成分,其中包括24個(gè)黃酮類成分、2個(gè)酰胺類化合物、1個(gè)糖苷類化合物和13個(gè)其它類化合物;確定給藥后血漿中發(fā)現(xiàn)了8個(gè)原型成分和4個(gè)代謝物。該研究能夠?yàn)殛U明藏藥莪達(dá)夏的藥效物質(zhì)基礎(chǔ)提供一定依據(jù),也對(duì)進(jìn)一步研究藏藥莪達(dá)夏有重要意義。
[Abstract]:In this study, LC-MS technique was used to analyze the in vitro chemical constituents of the Tibetan drug Erdaxia. The transitory components in plasma and liver microsomes of rats were separated by Diamondsil C18 column gradient elution after administration, and the spectra were collected under negative ion mode. Based on the analysis of the information of total ion flow diagram, the chemical constituents and their internal migration components of the water site of Erdaxia were studied qualitatively. 40 chemical constituents in the water site of Erdaxia were inferred. It includes 24 flavonoids, 2 amides, 1 glycoside and 13 other compounds. Eight prototypes and four metabolites were found in plasma after administration. This study can provide a basis for elucidating the substance basis of Tibetan medicine Erdasha, and it is also of great significance for further study of Tibetan medicine Erdasha.
【作者單位】： 青海大學(xué)生態(tài)環(huán)境工程學(xué)院;
【基金】：青海省自然科學(xué)基金項(xiàng)目 藏藥莪達(dá)夏改善大鼠心肌缺血再灌注損傷的物質(zhì)基礎(chǔ)研究(2014-ZJ-914)共同資助
【分類號(hào)】：R29
【正文快照】： *通訊作者,djzhang@nwibp.ac.cnMass Spectrometric Analysis on Chemical Constituents in Water Extractfrom Oxytropis falcata and Their Components in Rat PlasmaYuan Wangtao Zhang Benyin Zhang Yuhao Yang Zhanting Chen Ming Zhang Dejun*College of Eco-Environmen，

本文編號(hào)：1411096