發(fā)布時(shí)間：2018-01-09 15:08

  本文關(guān)鍵詞：防風(fēng)通圣丸治療單純性肥胖的臨床療效觀察及對(duì)LP、APN的影響　出處：《黑龍江中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 單純性肥胖 防風(fēng)通圣丸 瘦素 脂聯(lián)素

【摘要】：目的：觀察防風(fēng)通圣丸治療脾胃濕熱型單純性肥胖病的臨床療效及對(duì)瘦素(leptin, LP)、脂聯(lián)素(adiponectin, APN)的影響。方法：將符合納入標(biāo)準(zhǔn)的72例單純性肥胖患者隨機(jī)分為治療組和對(duì)照組,每組各36例。治療組采用基礎(chǔ)治療聯(lián)合防風(fēng)通圣丸,對(duì)照組采用基礎(chǔ)治療。各組療程均為3個(gè)月。觀察兩組患者治療前后體重、BMI、腰臀比(WHR)、中醫(yī)癥狀積分、血脂(包括TG、TC、LDL-C)及LP、APN水平的變化。結(jié)果：1.在體重、BMI及WHR方面,治療組治療前后比較,有顯著差異(P0.01),療效優(yōu)于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。2.在中醫(yī)癥狀方面,治療組與對(duì)照組進(jìn)行有效率比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；治療組各項(xiàng)癥狀積分治療前后比較,均有顯著差異(P0.01),而對(duì)照組治療前后比較,在口渴喜飲、口苦口臭、脘腹脹滿、大便秘結(jié)以及消谷善饑癥狀方面,差異顯著(P0.01)；治療組治療后與對(duì)照組相比,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),療效優(yōu)于對(duì)照組。3.兩組患者組內(nèi)治療前后的比較,血清LDL-C,兩組P值均0.05,差異無(wú)統(tǒng)計(jì)學(xué)意義。血清TC和血清TG,治療組治療前后相比,具有顯著差異(P0.01),對(duì)照組治療前后相比,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)；兩組治療后比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療組優(yōu)于對(duì)照組。4.LP、APN水平,治療組治療前后比較,具有顯著差異(P0.01),而對(duì)照組治療前后比較,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)；兩組治療后比較,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組優(yōu)于對(duì)照組。5.兩組患者治療前后血常規(guī)、尿常規(guī)、肝功、腎功均未見(jiàn)異常。結(jié)論：1.防風(fēng)通圣丸治療脾胃濕熱型單純性肥胖病,可顯著減輕患者體重,明顯減小BMI和WHR。2.防風(fēng)通圣丸能夠顯著改善脾胃濕熱型單純性肥胖病患者的中醫(yī)癥狀。3.防風(fēng)通圣丸治療脾胃濕熱型單純性肥胖病,可明顯降低血清TG和TC水平。4.防風(fēng)通圣丸可明顯降低脾胃濕熱型單純性肥胖患者的LP水平,明顯升高APN水平。
[Abstract]:Objective: to observe the clinical effect of Fangfeng Tongsheng pills on simple obesity of damp-heat type of spleen and stomach and to observe the effect of leptin leptin, LPU and adiponectin on spleen and stomach damp-heat type. Methods: 72 patients with simple obesity were randomly divided into treatment group and control group with 36 cases in each group. The treatment group was treated with basic treatment combined with Fangfeng Tongsheng pills. The patients in the control group were treated with basic therapy for 3 months. BMIs, WHR, TCM symptom scores and blood lipids (including TGG TC) were observed before and after treatment. Results: 1. In terms of body weight and WHR, there were significant differences before and after treatment in the treatment group (P 0.01), and the curative effect was better than that in the control group. In terms of TCM symptoms, the effective rate of the treatment group was compared with that of the control group, and the difference was statistically significant (P 0.05). Before and after treatment, there were significant differences in the scores of symptoms in the treatment group, while in the control group, there was a significant difference before and after treatment, in thirst, bitter halitosis and abdominal distension. There were significant differences in the symptoms of great constipation and good hunger (P 0.01). Compared with the control group, the treatment group after treatment, the difference was statistically significant (P 0.05), the curative effect was better than the control group. 3. The comparison between the two groups before and after treatment, serum LDL-C. Serum TC and TGwere significantly different before and after treatment in the treatment group and the control group before and after treatment. The difference was statistically significant (P 0.05). After treatment, the difference between the two groups was statistically significant, the treatment group was better than the control group. 4. The level of APN in the treatment group was significantly different before and after treatment (P 0.01). In the control group, the difference was statistically significant before and after treatment (P 0.05). Two groups after treatment, the difference was statistically significant, the treatment group is better than the control group. 5. before and after treatment of the two groups of patients blood routine, urine routine, liver function. Conclusion 1. Fangfeng Tongsheng pills can significantly reduce the weight of patients with simple obesity of damp-heat type of spleen and stomach. Significantly reduce BMI and WHR.2.Fangfeng Tongsheng pills can significantly improve the spleen and stomach damp-heat type of simple obesity symptoms .3.Fangfengtongsheng pills in the treatment of spleen and stomach damp-heat simple obesity. Fangfeng Tongsheng pills could significantly reduce LP level and increase APN level in simple obesity patients with damp-heat type of spleen and stomach.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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