本文關(guān)鍵詞：針灸治療對(duì)單純性肥胖患者腸道菌群的調(diào)節(jié)效應(yīng)　出處：《廣西中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 單純性肥胖 腸道菌群 針灸療法

【摘要】：目的:通過觀察針灸治療對(duì)單純性肥胖的臨床療效,特別注意其對(duì)腸道菌群的的調(diào)節(jié)效應(yīng),探討腸道菌群與肥胖發(fā)生的關(guān)系,佐證以“健脾溫腎”為則論治單純性肥胖的學(xué)術(shù)思想,為針灸臨床防治單純性肥胖提供客觀的理論依據(jù)。方法:本研究采用隨機(jī)分組法將符合納入標(biāo)準(zhǔn)的單純性肥胖患者60例分成2組,每組30人。分別為針灸治療組30例、基礎(chǔ)對(duì)照組30例。對(duì)照組予健康知識(shí)宣教,飲食控制配合合理運(yùn)動(dòng)。針灸治療組在對(duì)照組基礎(chǔ)上予針灸治療。隔日1次,10次為1療程,持續(xù)治療3個(gè)療程。以及選擇30例健康志愿者。用實(shí)時(shí)熒光定量PCR法檢測(cè)健康組及治療前后兩組患者腸道主要菌群的變化情況,并觀察身高、體重、BMI指數(shù)、腰圍、臀圍、腰臀比、中醫(yī)癥狀量化積分與療效及血脂的變化情況。全部數(shù)據(jù)以SPSS17.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:(1)腸道主要菌群:兩組患者治療前腸桿菌、腸球菌均高于健康組,經(jīng)治療后,治療組腸桿菌、腸球菌數(shù)量與本組治療前比較均明顯降低(P0.05),與健康組比較無統(tǒng)計(jì)學(xué)意義(P㧐0.05)。對(duì)照組治療前后比較差異無統(tǒng)計(jì)學(xué)意義(P㧐0.05),與健康組比較差異顯著(P0.05)。兩組患者治療前擬桿菌均低于健康組,治療后治療組擬桿菌數(shù)量與本組治療前比較均明顯升高(P0.05),與健康組比較無統(tǒng)計(jì)學(xué)意義(P㧐0.05)。對(duì)照組治療前后比較差異無統(tǒng)計(jì)學(xué)意義(P㧐0.05),與健康組比較差異顯著(P0.05)。兩組雙歧桿菌、乳桿菌治療前后與健康組比較均無顯著差異(P㧐0.05)。(2)體重、BMI、WHR:治療組在體重、BMI、WHR方面治療前后有顯著性差異(P0.05),而對(duì)照組雖然治療前后有差異,但(P0.05),沒有統(tǒng)計(jì)學(xué)意義。(3)血脂:治療組各項(xiàng)血脂指標(biāo)均顯著改善(P0.05),對(duì)照組除HDL-C外其余各項(xiàng)指標(biāo)治療前后均有顯著性差異(P0.05)(4)中醫(yī)癥狀積分:治療組中醫(yī)證候積分相對(duì)于治療前具有統(tǒng)計(jì)學(xué)差異(P0.05),治療組相對(duì)于對(duì)照組積分降低,具有統(tǒng)計(jì)學(xué)差異(P0.05)。(5)中醫(yī)臨床療效評(píng)價(jià):治療后對(duì)兩組病人進(jìn)行中醫(yī)癥狀療效評(píng)分,治療組顯效7例,有效20例,無效3例,總有效率90.0%;對(duì)照組顯效1例,有效9例,無效20例,總有效率30.3%;治療組與對(duì)照組比較有顯著性差異(P0.05)。結(jié)論:(1)腸道菌群與肥胖發(fā)生關(guān)系密切,體內(nèi)腸道微生態(tài)調(diào)節(jié)失衡可能是單純性肥胖發(fā)生重要機(jī)制之一。(2)針灸治療肥胖的機(jī)理之一可能是通過調(diào)節(jié)腸道菌群,糾正其紊亂,恢復(fù)機(jī)體微生態(tài)的動(dòng)態(tài)平衡,糾正其異常的代謝功能,從而加速能量的消耗,達(dá)到減肥之效。(3)以“健脾溫腎”為法論治單純性肥胖的學(xué)術(shù)思想具有臨床指導(dǎo)意義,而基于此的針灸組方合理有效。
[Abstract]:Objective: to investigate the relationship between intestinal flora and obesity by observing the clinical effect of acupuncture and moxibustion on simple obesity and paying special attention to its regulating effect on intestinal flora. It is proved that "invigorating the spleen and warming the kidney" is the academic thought of treating simple obesity. Methods: 60 patients with simple obesity who met the inclusion criteria were divided into two groups by random grouping method in order to provide an objective theoretical basis for clinical prevention and treatment of simple obesity by acupuncture and moxibustion. 30 persons in each group were divided into acupuncture treatment group (n = 30) and basic control group (n = 30). The control group was given health education. Diet control combined with reasonable exercise. Acupuncture and moxibustion treatment group in the control group on the basis of acupuncture and moxibustion treatment. Three courses of continuous treatment and 30 healthy volunteers were used to detect the changes of main intestinal flora in healthy group and before and after treatment by real-time fluorescence quantitative PCR, and to observe their height and weight. BMI index, waist circumference, hip circumference, waist-to-hip ratio. Quantitative score of TCM symptoms, curative effect and changes of blood lipids. All data were statistically analyzed by SPSS17.0 software. Results: main intestinal flora: two groups of patients treated with Enterobacter probioticum. After treatment, the number of Enterobacter and Enterococcus in the treatment group was significantly lower than that before treatment, but there was no significant difference between the treatment group and the healthy group. There was no significant difference between control group and control group before and after treatment. Compared with the healthy group, the difference was significant (P 0.05). Both groups were lower than the healthy group before treatment. After treatment, the number of Bacteroides in the treatment group was significantly higher than that before treatment, but there was no significant difference between the treatment group and the healthy group. There was no significant difference between control group and control group before and after treatment. There was no significant difference between the two groups in Bifidobacterium and Lactobacillus before and after treatment. BMI-WHR: there was a significant difference in the weight of BMI-WHR before and after treatment in the treatment group, while in the control group there was significant difference before and after treatment. However, there was no significant difference in blood lipids (P 0.05, P 0.05): all blood lipid indexes in the treatment group were significantly improved (P 0.05). In the control group, there were significant differences in the other indexes except HDL-C before and after treatment. (P0.05 / 4) the TCM symptom score of the treatment group was statistically different from that of the pre-treatment group (P < 0.05). P0.05). Compared with the control group, the score of the treatment group was lower than that of the control group, with statistical difference (P 0.05. 0. 05. 5) the clinical efficacy of TCM was evaluated: after treatment, 7 patients in the treatment group were scored with TCM symptom efficacy. 20 cases were effective, 3 cases were ineffective, the total effective rate was 90.0%. In the control group, there were 1 case with remarkable effect, 9 cases with effective effect and 20 cases with no effect, and the total effective rate was 30.3%. There was a significant difference between the treatment group and the control group (P 0.05). Conclusion the intestinal flora is closely related to obesity. The imbalance of intestinal microecological regulation may be one of the important mechanisms of simple obesity.) one of the mechanisms of acupuncture and moxibustion in treating obesity may be to correct the disorder by regulating the intestinal flora. To restore the dynamic balance of microecology, correct its abnormal metabolic function, and thus accelerate the energy consumption. The academic thought of "invigorating the spleen and warming the kidney" for treating simple obesity has clinical guiding significance, and the acupuncture formula based on it is reasonable and effective.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R246.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 聶文彬;王寅;;王寅健脾和胃法臨床經(jīng)驗(yàn)[J];北京中醫(yī)藥;2015年05期

2 邵鐵娟;李海昌;謝志軍;牛曉曼;溫成平;;基于脾主運(yùn)化理論探討脾虛濕困與腸道菌群紊亂的關(guān)系[J];中華中醫(yī)藥雜志;2014年12期

3 王菊菊;陳霞;于美玲;盧圣鋒;;基于數(shù)據(jù)挖掘的單純性肥胖癥現(xiàn)代針刺臨床用穴規(guī)律探析[J];北京中醫(yī)藥大學(xué)學(xué)報(bào);2014年11期

4 肖再軍;;針刺治療132例單純性肥胖療效評(píng)價(jià)[J];中醫(yī)臨床研究;2014年13期

5 萬文蓉;趙銀龍;單敬文;張衛(wèi);葉清景;葉志英;陳華;林華芳;;健脾降脂方針刺治療單純性肥胖癥126例臨床研究[J];北京中醫(yī)藥大學(xué)學(xué)報(bào)(中醫(yī)臨床版);2013年06期

6 陳茹;丁德光;;電針配合穴位埋線治療單純性肥胖并發(fā)脂肪肝臨床觀察[J];湖北中醫(yī)雜志;2013年06期

7 溫靜芳;李政;;針刺結(jié)合穴位埋線治療單純性肥胖的臨床研究[J];針灸臨床雜志;2013年05期

8 劉亞麗;張藜莉;楊麗娟;;不同波形電針治療單純性肥胖的臨床觀察[J];中醫(yī)藥信息;2013年03期

9 鄭寧;;溫陽益氣針灸方對(duì)治療氣虛質(zhì)單純性肥胖的研究[J];中國(guó)初級(jí)衛(wèi)生保健;2012年08期

10 賴龍勝;;針刺配合耳穴貼壓治療單純性肥胖180例療效評(píng)價(jià)[J];中醫(yī)藥臨床雜志;2012年06期

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