本文關(guān)鍵詞：開泄宣痹法治療胸悶變異性哮喘（痰阻氣痹證）的臨床研究　出處：《南京中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

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【摘要】：研究目的:基于胸悶變異性哮喘(Chesttightnessvariantasthma,CTVA)的文獻(xiàn)研究,對(duì)運(yùn)用開泄宣痹法治療胸悶變異性哮喘進(jìn)行臨床觀察,探討開泄宣痹方藥對(duì)于胸悶變異性哮喘的療效,并總結(jié)導(dǎo)師的證治經(jīng)驗(yàn),以期闡明開泄宣痹法治療胸悶變異性哮喘的臨證規(guī)律及作用,為中醫(yī)藥治療胸悶變異性哮喘提供臨床實(shí)驗(yàn)依據(jù)。研究方法:此研究以江蘇省中醫(yī)院呼吸科門診的胸悶變異性哮喘(痰阻氣痹證)患者為研究對(duì)象,采用小樣本對(duì)照試驗(yàn),隨機(jī)分組,中藥治療組和西藥對(duì)照組比例為1:1,中藥組20例,西藥組20例。中藥組予開泄宣痹方藥治療,療程:4周;西藥組予(布地奈德/福莫特羅干粉劑和孟魯司特鈉)治療。療程:4周。對(duì)比兩組治療前后各觀察時(shí)間點(diǎn)的癥狀積分和FENO檢測(cè)值以及PEF檢測(cè)值,并觀察治療過(guò)程中的安全性。結(jié)果:開泄宣痹方藥能夠有效改善CTVA急性發(fā)作期痰阻氣痹證患者的胸悶、咳嗽、氣喘等不適癥狀。治療組和對(duì)照組在治療前后積分差與證候積分改善率方面比較,P均0.05,顯示兩組療效相近;治療組在治療痰阻氣痹證的CTVA急性發(fā)作期患者的臨床綜合療效方面的癥候積分對(duì)比,P0.05,顯示無(wú)差異。在改善呼出氣一氧化氮方面,治療組和對(duì)照組均較治療前有所改善,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。整個(gè)實(shí)驗(yàn)過(guò)程中,未出現(xiàn)嚴(yán)重不良反應(yīng),說(shuō)明開泄宣痹方對(duì)于胸悶變異性哮喘的治療具有可靠的安全性。結(jié)論:開泄宣痹法治療CTVA臨床有效,在改善患者主要臨床癥狀方面較西藥具有優(yōu)勢(shì),值得進(jìn)一步研究推廣。
[Abstract]:Objective: to study the literature of Chesttightiness variant asthma (CTVA) based on chest tightness variant asthma. The clinical observation was carried out on the treatment of variant asthma of chest tightness with the method of opening and releasing Xuan Bi, the curative effect of Kaixuanbi prescription on variant asthma of chest tightness was discussed, and the experience of syndrome and treatment of tutor was summarized. The purpose of this study was to elucidate the clinical syndromes and effects of the method of opening, releasing and promoting arthralgia in the treatment of chest tightness variant asthma. To provide the clinical experimental basis for the treatment of chest tightness variant asthma with traditional Chinese medicine. Methods: this study took the patient of chest tightness variant asthma (phlegm blocking qi arthralgia syndrome) in respiratory department of Jiangsu Provincial traditional Chinese Medicine Hospital as the research object. The proportion of Chinese medicine treatment group and western medicine control group was 1: 1, 20 cases in traditional Chinese medicine group, 20 cases in western medicine group, and 20 cases in western medicine group. The western medicine group was treated with budesonide / formoterol powder and montelukast sodium for 4 weeks. The symptom scores, FENO and PEF were compared between the two groups before and after treatment. And observe the safety in the course of treatment. Results: the prescription can effectively improve the acute attack of CTVA patients with phlegm blocking Qi arthralgia syndrome chest tightness cough. The difference between the treatment group and the control group in the integral difference and the improvement rate of syndrome score were 0.05, which showed that the curative effect was similar between the two groups. Treatment group in the treatment of phlegm blocking qi arthralgia syndrome of patients with acute attack of CTVA in the clinical symptoms of the comparison of P0.05, showing no difference in improving the exhalation of nitric oxide. Treatment group and control group were improved compared with before treatment, the difference was not statistically significant (P 0.05). During the whole experiment, there was no serious adverse reaction. Conclusion: Kaixiexuanbi prescription is effective in the treatment of CTVA, and has advantages over western medicine in improving the main clinical symptoms of patients. It is worth studying and popularizing further.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R256.12

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