本文關(guān)鍵詞：白癜風(fēng)患者維醫(yī)辯證分型與血清甲狀腺自身抗體及甲狀腺素水平相關(guān)性研究　出處：《新疆醫(yī)科大學(xué)》2016年碩士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 白癜風(fēng) 自身免疫性甲狀腺病 異常黏液質(zhì) 維醫(yī)

【摘要】：目的:通過(guò)年齡和性別相匹配的原則,采用整群分層隨機(jī)抽樣方式抽取的482例白癜風(fēng)患者為研究對(duì)象,106例健康人為對(duì)照組,采用化學(xué)發(fā)光免疫分析法檢測(cè)血清中T3、T4、fT3、fT4、TSH、TGAB、TPOAb等甲狀腺功能指標(biāo),按年齡、性別,白癜風(fēng)不同分期,分型及維醫(yī)異常粘液質(zhì)分型等分層進(jìn)行比較,分析白癜風(fēng)患者維醫(yī)辯證分型與甲狀腺功能的相關(guān)性。方法:臨床研究觀察選取自治區(qū)維吾爾醫(yī)院皮膚科住院白癜風(fēng)患者,共482例病患入選,在自治區(qū)維吾爾醫(yī)院門(mén)診,保健科接受甲狀腺功能檢測(cè)的106健康人入選,空腹抽取肘靜脈血5ml,室溫靜止1h,按時(shí)間循序編號(hào),標(biāo)記患者姓名與編號(hào),保存在-80℃冰箱于每周內(nèi)集中檢測(cè)并結(jié)果記錄下來(lái)。通過(guò)皮膚CT、Wood燈、全身黑光等檢查確定白癜風(fēng)患者分型,咨詢(xún)患者的病史,最近3個(gè)月白斑有沒(méi)有擴(kuò)散等確定白癜風(fēng)患者分期,根據(jù)維醫(yī)辯證分析表及兩名副主任醫(yī)師以上維吾爾醫(yī)專(zhuān)家的評(píng)價(jià)來(lái)確定患者的異常體液分型。最終把所有的數(shù)據(jù)記錄下來(lái),采用統(tǒng)計(jì)學(xué)方法進(jìn)行多元統(tǒng)計(jì),分析白癜風(fēng)患者甲狀腺功能與維醫(yī)辯證分型的相關(guān)性。結(jié)果:共完成病例482例,對(duì)照組106例,兩組人群在平均年齡、年齡分布、總體性別比以及各年齡段性別比上差異無(wú)顯著性(P0.05),具有良好的可比性。兩組人群在民族構(gòu)成上有顯著性差異(P0.05),維吾爾族最多,其次是漢族。病例組性別不同的患者白癜風(fēng)臨床分型分布無(wú)顯著性差異(P0.05)。不同性別患者的維吾爾醫(yī)異常體液分型分布有顯著性差異,其中女性患者中咸味粘液質(zhì)較多見(jiàn)(p=0.01),男性患者中澀味粘液質(zhì)型較多見(jiàn)(P0.01),而淡味粘液質(zhì)型、凝固樣粘液質(zhì)型之間差異沒(méi)有統(tǒng)計(jì)學(xué)意義。病例組TGAB和TPOAb陽(yáng)性率分別為11.2%和21.8%,顯著高于健康對(duì)照組的1.9%和4.8%(P=0.002和0.001)。澀味粘液質(zhì)型白癜風(fēng)患者與非澀味粘液質(zhì)型白癜風(fēng)患者TGAB和TPOAb陽(yáng)性率之間無(wú)顯著性差異(p0.05)。不同臨床分型的白癜風(fēng)患者TGAB和TPOAb陽(yáng)性率之間無(wú)顯著性差異(p0.05)。各年齡段兩組間TGAB陽(yáng)性率差異無(wú)顯著性(PO.05)。白癜風(fēng)組18-45歲年齡段TPOAb陽(yáng)性率顯著高于同年齡段的健康人(P0.01),而小于18歲以及大于45歲兩個(gè)年齡段兩組間陽(yáng)性率差異無(wú)顯著性(P0.05)。澀味粘液質(zhì)型白癜風(fēng)組T3、T4和FT4水平顯著高于非澀味粘液質(zhì)型白癜風(fēng)組(P0.05),而FT3和TSH水平的差異無(wú)顯著性(P0.05)。澀味粘液質(zhì)型白癜風(fēng)T4的異常率顯著高于非澀味粘液質(zhì)型白癜風(fēng)患者(P0.01),而T3、FT3、FT4和TSH異常率的差異無(wú)顯著性(P0.05)。白癜風(fēng)組T3、T4和FT3、FT4水平顯著高于正常組(P0.01)。此外兩組間TSH水平的差異無(wú)顯著性(P0.05)。肢端性白癜風(fēng)患者FT4水平顯著高于其他臨床分型(P0.01),而其余無(wú)顯著性差異(P0.05)。結(jié)論:白癜風(fēng)患者TGAB和TPOAb陽(yáng)性率明顯高于健康人。18-45歲年齡段白癜風(fēng)患者TPOAb陽(yáng)性率顯著高于同年齡段的健康人,說(shuō)明白癜風(fēng)常伴發(fā)自身免疫性甲狀腺疾病,而且18-45之間高發(fā)。澀味粘液質(zhì)型白癜風(fēng)T3、T4和FT4水平顯著高于非澀味粘液質(zhì)型白癜風(fēng)患者。肢端性白癜風(fēng)患者FT4水平顯著高于其他臨床分型。白癜風(fēng)組T3和FT3異常率顯著高于正常組。說(shuō)明白癜風(fēng)患者甲狀腺功能檢測(cè)具有重要臨床意義,而且澀味粘液質(zhì)可能影響甲狀腺激素的降解,也可能是澀味粘液質(zhì)白癜風(fēng)和甲狀腺功能異常的主要病因,這需要更進(jìn)一步的研究。
[Abstract]:Objective: through matching the age and sex principle, with 482 cases of vitiligo patients from stratified random sampling as the research object, 106 healthy controls were determined by chemiluminescence immunoassay in serum T3, T4, fT3, fT4, TSH, TGAB, TPOAb and other parameters of thyroid function, according to the age vitiligo, gender, different stages, types and Uighur Medicine abnormal balgham type stratified comparison, correlation analysis of patients with vitiligo in Uyghur medicine dialectical type and thyroid function. Methods: the clinical study of hospitalized Uygur Autonomous Region Hospital Department of dermatology patients with vitiligo, a total of 482 patients enrolled in the outpatient hospital of Uygur Autonomous Region. Department of health care, accept thyroid function in 106 healthy people were selected, fasting venous blood 5ml, static at room temperature 1H number according to the time sequence, the patient's name and tag number stored in the -80 C refrigerator in a week In the centralized detection and record the results. Through the skin CT, Wood lamp, black light and other systemic examination to determine the type of vitiligo patients, consult the patient's medical history, the last 3 months have white spot diffusion to determine the staging of patients with vitiligo, according to Uighur medicine dialectical evaluation analysis and two associate chief physician of Uighur medicine experts to determine the type of the patients with abnormal helit. Finally put all the data recorded, using the statistical method of multivariate statistical analysis, the correlation of thyroid function in patients with vitiligo and doctor of dialectical type. Results: a total of 482 cases, 106 cases in the control group, the distribution of age among the two groups in mean age, sex ratio and overall. The age and sex ratio have no obvious difference (P0.05), has good comparability. There was significant difference in the ethnic composition of the two groups (P0.05), Uygur most, the second is the case group of Han nationality. Vitiligo patients in different clinical type distribution had no significant difference (P0.05). The abnormal body fluid in Uygur medicine patients with different types of distribution of gender has significant differences, in which women matter more salty mucus (p=0.01), more male patients see astringency phlegmatic type (P0.01), and mild phlegmatic the difference between the solidification type, like phlegmatic type was not statistically significant. The positive rate of cases in group TGAB and TPOAb were 11.2% and 21.8%, significantly higher than the healthy control group 1.9% and 4.8% (P=0.002 and 0.001). There was no significant difference between the astringency of phlegmatic type vitiligo patients and non astringent taste phlegmatic type TGAB and TPOAb in patients with vitiligo the positive rate (P0.05). There was no significant difference between the positive rate of TGAB and TPOAb in patients with vitiligo in different clinical types (P0.05). The difference of age between the two groups of TGAB positive rate had no significant (PO.05). The patients with vitiligo 18-45 age TPOAb The positive rate was significantly higher than that in healthy people the same age (P0.01), and less than 18 years old and 45 years old more than two age difference between the two groups was no significant (P0.05). The astringency of phlegmatic type vitiligo group of T3, T4 and FT4 were significantly higher than that of non astringent phlegmatic type vitiligo group (P0.05). The difference between FT3 and TSH levels had no significant difference (P0.05). The abnormal rate of astringency phlegmatic type T4 vitiligo was significantly higher than that of non astringent phlegmatic type vitiligo patients (P0.01), T3, FT3, FT4 and TSH abnormal rate of the difference was no significant (P0.05). T3 T4 and FT3 in vitiligo group, FT4. The level was significantly higher than the normal group (P0.01). In addition, the difference between the two groups no significant levels of TSH (P0.05). The level of FT4 in patients with acral vitiligo was significantly higher than that in other clinical classification (P0.01), while no significant difference (P0.05). Conclusion: Patients with vitiligo TGAB and TPOAb positive rate was significantly higher than that of healthy people.18-45 years of age The positive rate of TPOAb in patients with vitiligo were significantly higher than those of healthy people of the same age, vitiligo is often associated with autoimmune thyroid disease, and 18-45 high. The astringency phlegmatic type vitiligo T3, T4 and FT4 were significantly higher than that of non astringent phlegmatic type vitiligo patients. The level of FT4 in patients with acral vitiligo were significantly higher than those of other clinical types. Vitiligo group T3 and the abnormal rate of FT3 was significantly higher than the normal group. It has important clinical significance for detection of thyroid function in patients with vitiligo, and astringent mucus quality affecting the degradation of thyroid hormones, also may be the main cause of vitiligo and phlegmatic abnormal thyroid function astringency, which needs further study.

【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R29

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2 張倩;白癜風(fēng)患者外周血Treg細(xì)胞中HO-1表達(dá)、作用及機(jī)制研究[D];第四軍醫(yī)大學(xué);2015年

3 王冬雪;白癜風(fēng)患者血清抗黑素細(xì)胞抗體及其相關(guān)抗原的分析研究[D];河北北方學(xué)院;2015年

4 阿布都克力木·吐?tīng)栠d;喀什葛爾地區(qū)維吾爾族白癜風(fēng)患者外周血T細(xì)胞亞群相關(guān)研究[D];石河子大學(xué);2015年

5 沙揚(yáng);論文一:白癜風(fēng)患者血清氨基酸水平分析 論文二:肌球蛋白Ⅹ對(duì)人HaCaT細(xì)胞偽足的影響[D];大連醫(yī)科大學(xué);2015年

6 申楠;白癜風(fēng)患者外周血調(diào)節(jié)性B細(xì)胞數(shù)量及表面分子標(biāo)記的檢測(cè)[D];大連醫(yī)科大學(xué);2015年

7 吐?tīng)栠d他依·買(mǎi)買(mǎi)提依明（Tursuntay Mamtimin）;澀味粘液質(zhì)型白癜風(fēng)患者精神心理因素與血清5-HT、MT相關(guān)性研究[D];新疆醫(yī)科大學(xué);2016年

8 米吉提·吾普爾（Mijit Wupur）;白癜風(fēng)患者維醫(yī)辯證分型與血清甲狀腺自身抗體及甲狀腺素水平相關(guān)性研究[D];新疆醫(yī)科大學(xué);2016年

9 章俊;白癜風(fēng)患者血小板計(jì)數(shù)及其抗體的檢測(cè)[D];安徽醫(yī)科大學(xué);2007年

10 郭靜微;850例白癜風(fēng)患者的流行病學(xué)研究[D];吉林大學(xué);2012年

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