本文關(guān)鍵詞：加減壽胎丸聯(lián)合低分子肝素鈉治療腎虛血瘀型ACA陽(yáng)性RSA的研究　出處：《山東中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 加減壽胎丸 低分子肝素鈉 腎虛血瘀 抗心磷脂抗體陽(yáng)性 復(fù)發(fā)性流產(chǎn)

【摘要】：目的:觀察加減壽胎丸聯(lián)合低分子肝素鈉治療腎虛血瘀型抗心磷脂抗體陽(yáng)性復(fù)發(fā)性流產(chǎn)的臨床療效,從中醫(yī)角度分析ACA陽(yáng)性RSA的病機(jī),從腎虛血瘀論治,為臨床更好治療免疫性復(fù)發(fā)性流產(chǎn)提供新方法。方法:選擇ACA陽(yáng)性、中醫(yī)辨證為腎虛血瘀型的RSA患者73例,治療組懫用加減壽胎丸聯(lián)合低分子肝素鈉的中西醫(yī)結(jié)合方法,對(duì)照組單純采用低分子肝素鈉和地屈孕酮,比較兩組患者妊娠5-8周內(nèi)的β-HCG,E2,P水平;比較治療后孕7、8、12周國(guó)際標(biāo)準(zhǔn)化比值(INR),D-二聚體測(cè)定;比較兩組孕12周妊娠情況。結(jié)果:兩組患者妊娠5-8周內(nèi)β-HCG、E2有顯著差異,(P0.05),比較兩組P均無(wú)明顯差異(P0.05)。治療后測(cè)得孕7周時(shí)兩組INR、D-二聚體無(wú)明顯差別,(P0.05),孕8、12周兩組患者INR、D-二聚體有明顯差別(P0.05);兩組孕12周者繼續(xù)妊娠患者治療前后中醫(yī)癥狀積分有顯著差異,(P0.05);兩組孕12周妊娠情況比較有明顯差異(P0.05)。結(jié)論:中藥加減壽胎丸對(duì)提高孕早期β-HCG、E2有明顯效果,對(duì)P影響不大,對(duì)妊娠早期胎兒生長(zhǎng)發(fā)育有促進(jìn)作用;對(duì)改善INR、D-二聚體有明顯差異,加減壽胎丸聯(lián)合低分子肝素鈉改善凝血狀態(tài),可抑制血栓形成;妊娠12周時(shí),對(duì)比治療效果,治療組妊娠成功者明顯多于對(duì)照組;中藥加減壽胎丸聯(lián)合低分子肝素鈉治療ACA陽(yáng)性RSA從妊娠進(jìn)展、妊娠結(jié)局、凝血功能改善上明顯優(yōu)于低分子肝素鈉和地屈孕酮。
[Abstract]:Objective: To observe the clinical effect of Shoutai Pill and anticardiolipin antibody combined with low molecular heparin in treating kidney deficiency and blood stasis type positive recurrent abortion, analyzing the pathogenesis of ACA positive RSA from the viewpoint of traditional Chinese medicine, treatment from kidney deficiency and blood stasis, provides a new method for better clinical treatment of immunological recurrent spontaneous abortion. Methods: ACA positive, TCM 73 cases of kidney deficiency and blood stasis in patients with RSA, combined with the method of treatment group Zhi modified Shoutai Pill Combined with low molecular weight heparin sodium by traditional Chinese medicine and Western medicine, the control group was treated with low molecular heparin and dydrogestrone, compared two groups of patients with pregnancy 5-8 weeks of beta -HCG, E2, P after treatment at 7,8,12 level; week international normalized ratio (INR), two D- dimer determination; comparison between the two groups at 12 weeks of pregnancy. Results: 5-8 weeks of pregnancy in beta -HCG patients in the two groups, E2 had significant difference (P0.05), there were no significant differences between the two groups (P P0.05). After treatment, measured at 7 weeks when Two INR, two D- dimer showed no significant difference (P0.05), 8,12 weeks of gestation in two groups of patients with INR, two D- dimer (P0.05); there are obvious differences between the two groups at 12 weeks of pregnancy to patients before and after treatment of TCM symptom score had significant difference (P0.05); the two group at 12 weeks of pregnancy there was significant difference between (P0.05). Conclusion: the traditional Chinese medicine decoction of Shoutai Pill on early pregnancy increased beta -HCG, E2 have obvious effect, little effect on the P of early pregnancy, fetal growth promoting effect; to improve the INR, D- two dimers have obvious difference between the modified Shoutai Pill Combined with low molecular weight heparin to improve the coagulation state, can inhibit thrombosis; at 12 weeks gestation, compared treatment, the treatment group pregnancy are significantly more than the control group; Chinese medicine modified Shoutai Pill Combined with low molecular weight heparin sodium in the treatment of ACA positive RSA in the progression of pregnancy, pregnancy outcome, coagulation function improved significantly better than low molecular weight heparin and dydrogestrone.

【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R271.9

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